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Junior Faculty

Alexandra Surcel, Ph.D.

Alexandra Surcel, Ph.D.

Selected Publications:
Surcel A, Schiffhauer ES, Thomas D, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee E, Iglesias P, Anders R, Robinson DN. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv 190553; doi: https://doi.org/10.1101/190553. 2017
Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. Entosis is induced by glucose starvation. Cell Reports. 20(1): 201-210. 2017
Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang T-L, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA. Yes-Associated Protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am. J. Physiol. – Gastrointest. Liver Phys. 2016; In press.
Surcel A, Ng W-P, West-Foyle H, Zhu Q, Ren Y, Avery L, Krenc AK, Meyers D, Rock RS, Anders RA, Freel Meyers C, Robinson DN*. Pharmacological activation of myosin II paralogs to correct cell mechanics defects. Proc. Natl. Acad. Sci. USA 2015; 112(5): 1428-1433. 
Ren Y, West-Foyle H, Surcel A, Miller C, Robinson DN. Genetic suppression of a phosphomimic myosin II identifies system-level factors promoting myosin II cleavage furrow accumulation. Mol. Biol. Cell. 2014; 25: 4150-4165.
Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Tran ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN. 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889.

Wei Shao, Ph.D.

Wei Shao, Ph.D.

Selected Publications:
Gong X, Qian H, Shao W, Li J, Wu J, Li W, Espenshade PJ*, Nieng Y*. 2016. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 26:1197-1211. *Corresponding authors. PMCID: PMC5099872
Shao W, Machamer CE, Espenshade PJ. 2016. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res. 57:1564-1573.
Burr R, Stewart EV, Shao W, Zhao S, Hannibal-Bach HK, Ejsing CS, Espenshade PJ. 2016. Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast. J Biol Chem. 2016 Jun 3;291(23):12171-83. doi: 10.1074/jbc.M116.723650. Epub 2016 Apr 6.
Shao W, Espenshade PJ. 2015. Sugar Makes Fat by Talking to SCAP. Cancer Cell. 2015 Nov 9;28(5):548-9. doi: 10.1016/j.ccell.2015.10.011.
Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade PJ*, Nieng Y*. 2015. Crystal structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research 25:401-11. PMCID: PMC4387560  
Shao W, Espenshade PJ. 2014. Sterol Regulatory Element-binding Protein (SREBP) cleavage regulates Golgi-to-Endoplasmic Reticulum recycling of SREBP Cleavage-activating Protein (SCAP). J. Biol. Chem. 289:7547-7557.
Shao W, Espenshade PJ. 2012. Expanding roles for SREBP in metabolism. Cell Met. 16:414-419.

Eric Spear, Ph.D.

Eric Spear, Ph.D.

Selected Publications:
Maurer, M.J., Spear, E.D., Yu, A.T., Lee, E.J., Shahzad, S, and Michaelis, S.  (2016)  Degradation signals for ubiquitin-proteasome dependent cytosolic protein quality control (CytoQC) in yeast. G3:Genes, Genomes, Genetics 6:1853-66, PMC4938640.

Margaret (Maggie) De Cuevas, Ph.D.

Margaret (Maggie) De Cuevas, Ph.D.

Selected Publications:
Ma Q, de Cuevas M, Matunis EL. Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary. Development. 2016 Mar 1;143(5):754-63. doi: 10.1242/dev.129627. 
Ma Q, de Cuevas M, Matunis EL. 2016. Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary. Development Mar 1;143(5):754-63. doi: 10.1242/dev.129627. Epub 2016 Jan 25.
Greenspan LJ, de Cuevas M, Matunis E. Genetics of gonadal stem cell renewal. Annu Rev Cell Dev Biol. 2015;31:291-315. doi: 10.1146/annurev-cellbio-100913-013344. 
Hetie, P., de Cuevas, M. and Matunis, E.  2014.  Conversion of Quiescent Niche Cells to Somatic Stem Cells Causes Ectopic Niche Formation in the Drosophila Testis. Cell Reports 7, 715-721.
Matunis EL, Stine RR, de Cuevas M.  2012.  Recent advances in Drosophila male germline stem cell biology.  Spermatogenesis 2: 137-144.  PMID: 23087833.
de Cuevas, M., Matunis, E. L.  2011.  The stem cell niche: Lessons from the Drosophila testis.  Development 14:2861-2969.  
Issigonis, M., Tulina, N., de Cuevas, M., Brawley, C., Sandler, L., Matunis, E. 2009.  JAK-STAT signal inhibition regulates competition within the Drosophila testis stem cell niche.  Science 326:153-6.