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Pablo Iglesias, Ph.D.
Pablo Iglesias, Ph.D.
Edward J. Schaefer Professor of Electrical & Computer Engineering - Secondary Appointment in Cell Biology
Primary Appointment: Department of Electrical Engineering, Whiting School of Engineering, Johns Hopkins University
Johns Hopkins University
3400 N. Charles Street
Baltimore, MD 21218
Computational biology; use of control and information theory to study signal transduction pathways.
Pablo A. Iglesias was born in Caracas, Venezuela in 1964. He received the B.A.Sc.
degree in Engineering Science from the University of Toronto in 1987, and the Ph.D.
degree in Control Engineering from Cambridge University in 1991. Since then he has been
on the faculty of the Johns Hopkins University, where he is currently the Edward J.
Schaefer Professor of Electrical Engineering. He also holds appointments in the
Departments of Biomedical Engineering, and Applied Mathematics & Statistics. He has had
visiting appointments at Lund University (Automatic Control), The Weizmann Institute of
Science (Mathematics), the California Institute of Technology (Control and Dynamical
Systems), the Johns Hopkins School of Medicine (Cell Biology). He also spent the 2012-3
academic year on sabbatical at the Max-Planck Institute for the Physics of Complex
Systems in Dresden.
Dr. Iglesias has authored over 100 research articles as well as two books: Minimum
Entropy Control for Time-Varying Systems (Birkhäuser) and Control Theory and Systems
Biology (MIT Press). He has received a number of awards for both research (the Charles
E. Ives Best Paper award for the Journal of Imaging Technology) and teaching (the George
E. Owen Teaching Award at Johns Hopkins University) and also named a Distinguished
lecturer for the IEEE Control Systems Society.
Dr. Iglesias’s research focuses on the use of control and information theory to study
biological signal transduction pathways. Among his research interests are: understanding
how cells interpret directional cues to guide cell motion, the regulatory mechanisms that
control cell division, and the sensing and actuation that enable cells to maintain lipid
Li X, Edwards M, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, and Devreotes PN. 2018. Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration. PNAS published ahead of print Sept. 7, 2018. https://doi.org/10.1073/pnas.1809039115
Artemenko Y, Axiotakis L Jr., Borleis J, Iglesias PA, Deveotes PN. 2016. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proc Natl Acad Sci USA. Nov. 22; 113(47):E7500-E7509. PMCID: PMC5127353 [ link ]
Srivastava V, Iglesias PA, Robinson DN*. 2016. Cytokinesis: Robust cell shape regulation. Semin. Cell Dev. Biol. 2016; 53:39-44.
Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis E, Iglesias PA, Robinson DN*. Mechanoaccumulative elements of the mammalian actin cytoskeleton. Curr. Biol. 2016; 26: 1473-1479.
Swaney K.F., Borleis J., Iglesias P.A., and Devreotes, P.N. 2015. Novel protein Callipygian defines the back of migrating cells. PNAS 2015 Jun 30. pii:201509098. [Epub ahead of print]
Wang M, Artemenko Y, Cai W, Iglesias PA and Peter N. Devreotes. (2014). The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient. Cell Rep Nov 6;9(3):1110-21. doi: 10.1016/j.celrep.2014.09.047. Epub 2014 Oct 23. PMID: 25437564 [PubMed - in process]. PMCID:PMC4250826
Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, and Huang CH (2014). Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nat Commun. Oct 27;5:5175. PMCID: PMC4211273 [Available on 2015/4/27)]
Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, and Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science. 2014 Mar 21;343(6177):1249531. doi: 10.1126/science.1249531.
Huang, C.,Tang, M., Shi, C., Iglesias, P., and Devreotes, P.N. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol. 2013 Nov;15(11):1307-16.
Luo T, Mohan K, Iglesias PA, Robinson DN. Molecular mechanisms of cellular mechanosensing. Nat. Mater. 2013; 12: 1064-1071.
Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN. A mechanosensory system governs myosin II accumulation in dividing cells. Mol. Biol. Cell 2012; 23(8): 1510-1523.
Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012; 8(4): e1002467.
Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN. Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J. 2012; 102(2): 238-247.
Porter JR, Lee CSY, Espenshade PJ, Iglesias PA. 2012. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol. Biol. Cell 23:3764-3774.
Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Tran ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN. 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889.
Porter JR, Burg JS, Espenshade PJ, Iglesias PA. 2010. Ergosterol regulates SREBP cleavage in fission yeast. J. Biol. Chem. 285:41051-61.
Xiong, Y., Huang, C-H, Iglesias, P.A., and Devreotes, P.N. 2010. Cells navigate with a local-excitation, global-inhibition-biased excitable network. PNAS, 107:17079-17086.
Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock, RS, Robinson DN. Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr. Biol. 2009; 19(17):1421-1428.
Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.* 2008. Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 18: 471-480. PMCID: PMC2361134
Chen, L., Iijima, M., Tang, M., Landree, M.A. Huang, Y.E., Xiong, Y., Iglesias, P.A., Devreotes, P.N. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Developmental Cell. Developmental Cell. (2007) 12: 603-614.
Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. PMCID: PMC2474462
Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8951-6. PMC428453.