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Publications

2007

Nyasae, L., Bustos, R., Braiterman, L., Eipper, B., A. Hubbard. 2007. Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites. Am J Physiol Gastrointest Liver Physiol. 292(4):G1181-94.
Margalit A, Neufeld E, Feinstein N, Wilson KL, Podbilewicz B and Gruenbaum Y (2007).  Barrier to autointegration factor (BAF) blocks premature cell fusion and maintains adult muscle integrity in C. elegans. J Cell Biology 178:661-673. 
Cerveny, K.L., Tamura, Y., Zhang, Z., and Jensen, R.E. and Sesaki, H. (2007). Regulation of mitochondrial fusion and division. Trends Cell Biol. 17: 563-569.
Peixoto, P.M. et al. (2007) Awaking TIM22: A dynamic ligand-gated channel for protein insertion in the mitochondrial inner membrane. J. Biol. Chem. 282: 18694-18701.

2006

Grazioli, A, Alves, C.S., Konstantopoulos, K and Yang, J.T. (2006). Defective blood vessel development and pericyte/pvSMC distribution in α4 integrin-deficient mouse embryos. Dev. Biol. 393,165-177.
Sesaki, H. Dunn, C.D., Iijima, M., Shepard, K.A., Yaffe, M.P., Machamer, C.E., and Jensen, R.E. (2006). Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J. Cell Biol. 173: 651-658. 
Somesh, B.P., Vlahou, G., Iijima, M., Insall, R.H., Devreotes, P.N., Rivero, F. RacG regulates morphology, phagocytosis and chemotaxis. Eukaryot Cell. (2006) 5: 1648-1663.
Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. PMCID: PMC2474462
Hicks, S.W., T.A. Horn, J.M. McCaffery, D.M. Zuckerman,and C.E. Machamer. 2006. Golgin-160 promotes cell surface expression of the beta-1-adrenergic receptor. Traffic 7:1666-1677.
Williams, D., S.W. Hicks, C.E. Machamer, and J.E. Pessin. 2006. Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes., Molec. Biol. Cell 17:5346-5355.
Zastrow MS, Flaherty DB, Benian GM and Wilson KL (2006). Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. J. Cell Science 119:239-249.
Montes de Oca R, Lee KK and Wilson KL (2006). Binding of barrier-to-autointegration factor (BAF) to histone H3 and selected linker histones including H1.1.  J Biological Chemistry 280:42252-62
Terry, N.A, Tulina, N., Matunis, E., DiNardo S.  2006.  Novel regulators revealed by profiling Drosophila testis stem cells within their niche.  Dev. Biol. 294:246-257. 
Sbodio, J.I., S.W. Hicks, D. Simon, and C.E. Machamer. 2006. GCP60 preferentially interacts with a caspase-generated golgin-160 fragment. J. Biol. Chem. 281:27924-27931.
Suh BC*, Inoue T*, Meyer T, and Hille B. “Rapid chemically-induced changes of PtdIns(4,5)P2 gate KCNQ ion channels” Science 314, 1454-1457 (2006) (*Contributed Equally) Note: “Perspectives” (Science 314, 1402-1403 (2006)), “Editor’s Choice” (Science STKE 364, tw410 (2006)), “Spotlight” (ACS Chem. Biol. 1, 608 (2006)), “Research Highlights” (Nature Methods 4, 7 (2007))
Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, and Meyer T. “PI(3,4,5)P3 and PI(4,5)P2 lipids target Ras, Rho, Arf and Rab GTPases to the plasma membrane” Science 314, 1458-1461 (2006)
Girard, K.D., Kuo, S.C., and Robinson, D.N. (2006) Dictyostelium myosin-II mechanochemistry promotes active behavior of the cortex on long time-scales. PNAS 103, 2103-2108
Abrams, E.W., Mihoulides, W.K. and Andrew, D.J. (2006) Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4áSG1 and PH4áSG2. Development 133: 3517-3527. PMID: 16914497.
Jensen, R.E. and Sesaki, H. (2006) Ahead of the curve: mitochondrial fusion and phospholipase D. Nat. Cell Biol. 8:1215-2157.

2005

Song S, Ewald, AJ, Stallcup B. Werb, Z. and G. Bergers. PDGFR±+ perivascular progenitor cells in tumors regulate pericyte differentiation and vascular survival. Nature Cell Biology, 2005, Sep; 7(9) :870-9. Must Read 6.0 on Faculty of 1000, 10/28/05.
Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P.N. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Developmental Cell. (2005) 8: 467-477.
Zhang W., Robinson DN.* Balance of actively generated contractile and resistive forces controls cytokinesis dynamics. Proc. Natl. Acad. Sci. USA 2005; 102(20):7186-7191. PMCID: PMC1129136
Abrams, E.W. and Andrew, D.J. (2005) CrebA regulates secretory activity in the salivary gland and epidermis.  Development 132: 2743-2758. PMID: 15901661
Youn, S., E.W. Collisson, and C.E. Machamer. 2005. Contribution of trafficking signals in the cytoplasmic tail of the infectious bronchitis virus spike protein to virus infection. J. Virol. 79 13209-13217.
Pendleton, A.R., and C. E. Machamer. 2005. Infectious bronchitis virus 3a protein localizes to a unique punctate domain of the smooth endoplasmic reticulum. J. Virol.,79:6142-6151.
Mallampalli, M. P., Huyer, G., Bendale, P., Gelb, M. H., and Michaelis, S. (2005) Inhibiting Farnesylation Reverses the Nuclear Morphology Defect in a HeLa Cell Model for Hutchinson-Gilford Progeria Syndrome, Proc Natl. Acad Sci. USA 102:14416-14421.
Young, S. G. Fong, L., and Michaelis, S.  (2005) Prelamin A, Zmpste24, misshapen cell nuclei, and progeria- new evidence suggesting that protein farnesylation could be important for disease pathogenesis.  Journal of Lipid Research 46:2531-2558.  
Wawersik, M., Milutinovich, A. Matunis, E., Williams, B. Van Doren, M.  2005.  Somatic control of germline sexual differentiation is mediated by the JAK/STAT pathway. Nature 436:563-567.  
Hicks, S.W. and C.E. Machamer. 2005. Golgi structure in stress sensing and apoptosis. Biochim. Biophys. Acta 1744:406-414.
Maag, R., M. Mancini,R, A. Rosen and C. E. Machamer. 2005. Caspase-resistant golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. Molec. Biol. Cell 16:3019-2027.
Hicks, S.W. and C.E. Machamer. 2005. Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST. J. Biol. Chem 280:28944-28951.
Inoue T, Heo WD, Grimley JS, Wandless TJ, and Meyer T. “Inducible translocation strategies to rapidly activate and inhibit small GTPase signaling pathways” Nature Methods 2, 415-418 (2005)
Guo, Y, L. Nyasae, L. T. Braiterman, and A. L. Hubbard. 2005. N-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Amer J. Physiol., GI/Liver 289(5):G904-16.
Hughes AL, Todd BL, Espenshade PJ. 2005. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120:831-842.

2004

Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8951-6. PMC428453
Brawley, C, Matunis, E. 2004. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivoScience 304:1331-1334.
Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F., Devreotes, P.N. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J. Biol. Chem. (2004) 16: 16606-16613.
Ewald, AJ, Peyrot, S, Tyszka, JM, Fraser, SE, Wallingford, J. Regional requirements for Dishevelled signaling during Xenopus gastrulation: Separable effects on blastopore closure, mesendoderm internalization, and archenteron formation. Development, 2004, Dec Part 2; 131(24): 6195-6209.
Girard, K.D., Chaney, C., Delannoy, M., Kuo, S.C., and Robinson, D.N. (2004) Dynacortin contributes to cortical viscoelasticity and helps define the shape changes of cytokinesis. EMBO J 23(7), 1536-46

2003

Wallenfang MR, Matunis E.  2003.  Developmental biology. Orienting stem cells.  Science. 301: 1490-1.  PMID: 12970553.
Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes” Chem. Biol. 10, 503-509 (2003) Note: “Cover art”
Bradley, P.L., Myat, M.M., Comeaux, C. and Andrew, D.J. (2003) Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.  Developmental Biology 257:  249-262. PMID: 12729556
Kupfer, A. and Kupfer, H. (2003) Imaging immune cell interactions and functions: SMACs and the immunological synapse. Seminars in Immunology 19:4712-4722.
Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P.N., Snyder, S.H. Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions. Cell. (2003) 114: 559-572.
Chen, H, Detmer, SA, Ewald AJ, Griffin, EE, Fraser SE, and Chan, DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Journal of Cell Biology, 2003, Jan 20; 160(2): 189-200.
McGrath, J.L., Eungdamrong, J., Fisher, C.I., Peng, F., Mahadevan, L., Mitchison, T.J., and Kuo, S.C. (2003) The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol 13, 329-332

2002

Sengbusch, J.K., He W., Pinco, K.A. and Yang, J.T. (2002). Dual functions of α4β1 integrin in epicardial development: initial migration and long term attachment. J. Cell Biol.157, 873-882. 
Pinco, K. A., He W., and Yang, J. T. (2002). α4β1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol. Biol. Cell 13, 3203-3217.
Iijima, M., Huang, Y.E., Devreotes, P.N. Temporal and spatial regulation of chemotaxis. Developmental Cell. (2002) 4; 469-478.
Freiberg, B. A., Kupfer, H., Maslanik, W., Delli, J., Kappler, J., Zaller, D.M. and Kupfer, A. (2002) Staging and resetting T cell activation in SMACs. Nat. Immunol. 18:6201-6208.
Myat, M.M. and Andrew, D.J. (2002) Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Cell 111:879-891. PMID: 12526813.
Iijima, M. and Devreotes, P. N. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610 (Cover).

2001

Sesaki, H. and Jensen, R.E. (2001). UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol. 152:1123-34. 
Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor” Chem. Biol. 8, 9-15 (2001)
Bradley, P.L. and Andrew, D.J. (2001) ribbon encodes a BTB-containing transcription factor required for directed cell migration.  Development 128: 3001-3015. PMID: 11532922
Tulina, N., Matunis, E. 2001.  Control of Stem cell self-renewal in Drosophila  spermatogenesis by Jak-STAT signaling.  Science 294: 2546-2549.
Potter, T.A., K. Grebe, B. Freiberg, and Kupfer, A. (2001) Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 92:819-828.
Wallingford, JB, Ewald, AJ, Harland, RM and Fraser, SE. Calcium signaling during convergent extension in Xenopus. Current Biology, 2001, May 1; 11(9):652-661. Selected for Cover.
Janetopoulos, C., Jin, T. and Devreotes, P.N. 2001. Receptor mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411.

2000

Robinson DN*, Spudich JA. Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium cytokinesis mutant. J. Cell Biol. 2000; 150(4):823-838. PMCID: PMC2175282
Myat, M.M. and Andrew, D.J. (2000) Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia.  Development 127: 679-691. PMID: 10648227
Myat, M.M. and Andrew, D.J. (2000) FORK HEAD prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands.  Development 127: 4217-4226. PMID: 10976053
Kupfer, A. (2000) Breaking up receptor alliances: the parting of CD3 and CD4. Nature Medicine 16:2248-2254.
Kuo, S.C., and McGrath, J. L. (2000) Steps and fluctuations of Listeria monocytogenes during actin-based motility. Nature 407, 1026-9
Yamada, S., Wirtz, D., and Kuo, S.C. (2000) Mechanics of living cells measured by laser tracking microrheology (LTM). Biophys. J. 78, 1736-47.

1999

Sesaki, H. and Jensen, R.E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147: 699-706. 
Parent, C. and Devreotes, P.N. 1999. A Cell's Sense of Direction. Science, 284, 765-770.

1998

Monks, C.R.F., B.A. Freiberg, H. Kupfer, N. Sciaky, and Kupfer, A. (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 166:4773-4779.
Parent, C., Blacklock, B., Froelich, W., Murphy, D. and Devreotes, P.N. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell, 95, 81-91.

1997

Chen MY, Long Y, Devreotes PN. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 1997 Dec 1;11(23):3218-31. PMC316743
Xiao Z, Zhang N, Murphy DB, Devreotes PN. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J Cell Biol. 1997 Oct 20;139(2):365-74. PMC2139806
Monks, C.R.F., Kupfer, H., Tamir, I., Barlow, A., and Kupfer, A. (1997) Selective modulation of protein kinase C-theta during T-cell activation. Nature 46 (Suppl): S67-S72.

1996

Isaac, D.D. and Andrew, D.J. (1996) Tubulogenesis in Drosophila:  A requirement for the trachealess gene product.  Genes and Development 10: 103-117. PMID: 8557189
Bhanot, P., Brink, M., Samos, C.H., Hsieh, J.-C., Wang, Y., Macke, J.P., Andrew, D., Nathans, J., and Nusse, R. (1996) Dfz2, a new member of the frizzled family in Drosophila, functions as a receptor for Wingless.  Nature 382: 225-230.  PMID: 8717036

1994

Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol. 1994 Sep;126(6):1537-45. PMC2290948

1993

Lilly P, Wu L, Welker DL, Devreotes PN. A G-protein beta-subunit is essential for Dictyostelium development. Genes Dev. 1993 Jun;7(6):986-95. PMID: 8099335.

1992

Pitt, G.S., Milona, N., Borleis, J., Lin, K.C., Reed, R.R. and Devreotes, P.N. 1992. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyosteilum development. Cell 69, 305-315.

1988

Klein, P.S., Sun, T.L., Saxe, C.L. III, Kimmel, A.R., Johnson, R.L. and Devreotes, P.N.  1988.  A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241, 1467-1472.

1981

Tomchik KJ, Devreotes PN. Adenosine 3',5'-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution--fluorography. Science. 1981 Apr 24;212(4493):443-6. (Cover Article). PMID: 6259734
Tomchik, K.J. and Devreotes, P.N. 1981. Cyclic AMP waves in Dictyostelium discoideum: A demonstration by isotope dilution fluorography. Science 212, 443-446. (COVER)

1979

Devreotes PN, Steck TL. Cyclic 3',5' AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. J Cell Biol. 1979 Feb;80(2):300-9. PMC2110342

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