Duis autem vel eum iriure dolor in hendrerit.

Publications

2004

Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8951-6. PMC428453
Brawley, C, Matunis, E. 2004. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivoScience 304:1331-1334.
Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F., Devreotes, P.N. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J. Biol. Chem. (2004) 16: 16606-16613.
Ewald, AJ, Peyrot, S, Tyszka, JM, Fraser, SE, Wallingford, J. Regional requirements for Dishevelled signaling during Xenopus gastrulation: Separable effects on blastopore closure, mesendoderm internalization, and archenteron formation. Development, 2004, Dec Part 2; 131(24): 6195-6209.
Girard, K.D., Chaney, C., Delannoy, M., Kuo, S.C., and Robinson, D.N. (2004) Dynacortin contributes to cortical viscoelasticity and helps define the shape changes of cytokinesis. EMBO J 23(7), 1536-46

2003

Wallenfang MR, Matunis E.  2003.  Developmental biology. Orienting stem cells.  Science. 301: 1490-1.  PMID: 12970553.
Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes” Chem. Biol. 10, 503-509 (2003) Note: “Cover art”
Bradley, P.L., Myat, M.M., Comeaux, C. and Andrew, D.J. (2003) Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.  Developmental Biology 257:  249-262. PMID: 12729556
Kupfer, A. and Kupfer, H. (2003) Imaging immune cell interactions and functions: SMACs and the immunological synapse. Seminars in Immunology 19:4712-4722.
Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P.N., Snyder, S.H. Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions. Cell. (2003) 114: 559-572.
Chen, H, Detmer, SA, Ewald AJ, Griffin, EE, Fraser SE, and Chan, DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Journal of Cell Biology, 2003, Jan 20; 160(2): 189-200.
McGrath, J.L., Eungdamrong, J., Fisher, C.I., Peng, F., Mahadevan, L., Mitchison, T.J., and Kuo, S.C. (2003) The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol 13, 329-332

2002

Sengbusch, J.K., He W., Pinco, K.A. and Yang, J.T. (2002). Dual functions of α4β1 integrin in epicardial development: initial migration and long term attachment. J. Cell Biol.157, 873-882. 
Pinco, K. A., He W., and Yang, J. T. (2002). α4β1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol. Biol. Cell 13, 3203-3217.
Iijima, M., Huang, Y.E., Devreotes, P.N. Temporal and spatial regulation of chemotaxis. Developmental Cell. (2002) 4; 469-478.
Freiberg, B. A., Kupfer, H., Maslanik, W., Delli, J., Kappler, J., Zaller, D.M. and Kupfer, A. (2002) Staging and resetting T cell activation in SMACs. Nat. Immunol. 18:6201-6208.
Myat, M.M. and Andrew, D.J. (2002) Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Cell 111:879-891. PMID: 12526813.
Iijima, M. and Devreotes, P. N. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610 (Cover).

2001

Sesaki, H. and Jensen, R.E. (2001). UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol. 152:1123-34. 
Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor” Chem. Biol. 8, 9-15 (2001)
Bradley, P.L. and Andrew, D.J. (2001) ribbon encodes a BTB-containing transcription factor required for directed cell migration.  Development 128: 3001-3015. PMID: 11532922
Tulina, N., Matunis, E. 2001.  Control of Stem cell self-renewal in Drosophila  spermatogenesis by Jak-STAT signaling.  Science 294: 2546-2549.
Potter, T.A., K. Grebe, B. Freiberg, and Kupfer, A. (2001) Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 92:819-828.
Wallingford, JB, Ewald, AJ, Harland, RM and Fraser, SE. Calcium signaling during convergent extension in Xenopus. Current Biology, 2001, May 1; 11(9):652-661. Selected for Cover.
Janetopoulos, C., Jin, T. and Devreotes, P.N. 2001. Receptor mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411.

2000

Robinson DN*, Spudich JA. Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium cytokinesis mutant. J. Cell Biol. 2000; 150(4):823-838. PMCID: PMC2175282
Myat, M.M. and Andrew, D.J. (2000) Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia.  Development 127: 679-691. PMID: 10648227
Myat, M.M. and Andrew, D.J. (2000) FORK HEAD prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands.  Development 127: 4217-4226. PMID: 10976053
Kupfer, A. (2000) Breaking up receptor alliances: the parting of CD3 and CD4. Nature Medicine 16:2248-2254.
Kuo, S.C., and McGrath, J. L. (2000) Steps and fluctuations of Listeria monocytogenes during actin-based motility. Nature 407, 1026-9
Yamada, S., Wirtz, D., and Kuo, S.C. (2000) Mechanics of living cells measured by laser tracking microrheology (LTM). Biophys. J. 78, 1736-47.

1999

Sesaki, H. and Jensen, R.E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147: 699-706. 
Parent, C. and Devreotes, P.N. 1999. A Cell's Sense of Direction. Science, 284, 765-770.

1998

Monks, C.R.F., B.A. Freiberg, H. Kupfer, N. Sciaky, and Kupfer, A. (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 166:4773-4779.
Parent, C., Blacklock, B., Froelich, W., Murphy, D. and Devreotes, P.N. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell, 95, 81-91.

1997

Chen MY, Long Y, Devreotes PN. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 1997 Dec 1;11(23):3218-31. PMC316743
Xiao Z, Zhang N, Murphy DB, Devreotes PN. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J Cell Biol. 1997 Oct 20;139(2):365-74. PMC2139806
Monks, C.R.F., Kupfer, H., Tamir, I., Barlow, A., and Kupfer, A. (1997) Selective modulation of protein kinase C-theta during T-cell activation. Nature 46 (Suppl): S67-S72.

1996

Isaac, D.D. and Andrew, D.J. (1996) Tubulogenesis in Drosophila:  A requirement for the trachealess gene product.  Genes and Development 10: 103-117. PMID: 8557189
Bhanot, P., Brink, M., Samos, C.H., Hsieh, J.-C., Wang, Y., Macke, J.P., Andrew, D., Nathans, J., and Nusse, R. (1996) Dfz2, a new member of the frizzled family in Drosophila, functions as a receptor for Wingless.  Nature 382: 225-230.  PMID: 8717036

1994

Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol. 1994 Sep;126(6):1537-45. PMC2290948

1993

Lilly P, Wu L, Welker DL, Devreotes PN. A G-protein beta-subunit is essential for Dictyostelium development. Genes Dev. 1993 Jun;7(6):986-95. PMID: 8099335.

1992

Pitt, G.S., Milona, N., Borleis, J., Lin, K.C., Reed, R.R. and Devreotes, P.N. 1992. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyosteilum development. Cell 69, 305-315.

1988

Klein, P.S., Sun, T.L., Saxe, C.L. III, Kimmel, A.R., Johnson, R.L. and Devreotes, P.N.  1988.  A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241, 1467-1472.

1981

Tomchik KJ, Devreotes PN. Adenosine 3',5'-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution--fluorography. Science. 1981 Apr 24;212(4493):443-6. (Cover Article). PMID: 6259734
Tomchik, K.J. and Devreotes, P.N. 1981. Cyclic AMP waves in Dictyostelium discoideum: A demonstration by isotope dilution fluorography. Science 212, 443-446. (COVER)

1979

Devreotes PN, Steck TL. Cyclic 3',5' AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. J Cell Biol. 1979 Feb;80(2):300-9. PMC2110342

Pages