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Recent Publications

A listing of publications from the last 12 months...

2017

Greenspan LJ, Matunis EL. 2017. Live Imaging of the Drosophila Testis Stem Cell Niche. Methods Mol Biol. 1463:63-74.
Burr R, Stewart EV, Espenshade PJ. 2017. Coordinate regulation of yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 transcription factors. J. Biol. Chem. 292:5311-5324. PMCID: PMC5392677
Adachi Y, Itoh K, Iijima M, Sesaki H. 2017. Assay to measure interactions between purified Drp1 and synthetic liposomes. Bio-Protocol. Vol 7, Iss 9.
Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. 2017. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab. 25(3):647-660.  
Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM. 2017. The putative Drp1 inhibitor mdivi-1 Is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species. Dev Cell. 2017;40(6):583-594.
Adachi Y, Iijima M, Sesaki H. An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid.  2017 Jun 23:1-8. doi: 10.1080/21541248.2017.1321614. [Epub ahead of print]
Florwick A, Dharmaraj T, Jurgens J, Valle D, Wilson KL. 2017.  LMNA sequences of 60,706 unrelated individuals reveal 132 novel missense variants in A-type lamins and suggest a link between variant p.G602S and Type 2 Diabetes.  Jun 15;8:79. doi: 10.3389/fgene.2017.00079. eCollection 2017.
Pereira R, Tadinada SM, Zasadny FM, Oliveira K, Pires KM, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. 2017. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.  2017 Jun 12. pii: e201696179. doi: 10.15252/embj.201696179. [Epub ahead of print]
Cho B, Cho HM, Jo MY, Kim HD, Song M, Moon C, Kim H, Kim K, Sesaki H, Rhyu IJ, Kim H. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division.  2017 Jun 9;8:15754. doi: 10.1038/ncomms15754.  
Watanabe S. and Boucrot E. (2017) Fast and ultrafast endocytosis. Curr Opin Cell Biol. 5;47:64-71.
Topalidou I, Chen PA, Cooper K, Watanabe S, Jorgensen EM, Ailion M. (2017). The NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans. Genetics May;206(1):265-282.
Schiffhauer E, Robinson DN. 2017. Mechanochemical signaling directs cell shape change. Biophys. J. 112: 207-214. (Featured article)
Kothari P, Schiffhauer E, Robinson DN. Cytokinesis from nanometers to micrometers and microseconds to minutes. 2017. Methods Cell Biol. 137:307-322.
Yamada T, Adachi Y, Yanagawa T, Iijima M, Sesaki H. 2017. p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. Neurochem Int. 2017 May 18. pii: S0197-0186(17)30189-4. doi: 10.1016/j.neuint.2017.05.012. [Epub ahead of print]
Rohani A, Moore JH, Kashatus JA, Sesaki H, Kashatus DF, Swami NS. Label-Free Quantification of Intracellular Mitochondrial Dynamics Using Dielectrophoresis. Anal Chem. 2017 Jun 6;89(11):5757-5764. doi: 10.1021/acs.analchem.6b04666. Epub 2017 May 15
Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel M, Gabelli SB, Cole PA.  2017. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell 66 (3): 345-357. PMID: 28475870. DOI: 10.1016/j.molcel.2017.03.020
Xian L, Georgess D, Huso T, Cope L, Belton A, Chang YT, Kuang W, Zhang X, Senger S, Fassano A, Huso DL, Ewald AJ, Resar LMS. 2017. HMGA1 Amplifies Wnt Signaling and Expands the Intestinal Stem Cell Compartment and Paneth Cell Niche. Nat Communications, 2017 Apr 28;8:15008
Wells MB, Villamor J, and Andrews DJ. Salivary gland maturation and duct formation in the African malaria mosquito Anopheles gambiae. 2017. Scientific Reports 7:601. DOI: 10.1038/s41598-017-00672-0.
Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias P, Devreotes PN. 2017.  Altering the threshold of an excitable signal transduction network changes cell migratory modes.  Nat Cell Biol 19:329-340.
Ruan L, Zhou C, Jin E, Kucharavy A, Zhang Y, Wen Z, Florens L, Li R. 2017. Cytosolic proteostasis through importing of misfolded proteins into mitochondriaNature; Mar 16; 543, 443–446; doi:10.1038/nature21695
Yang J-M,  Schiapparelli P,  Nguyen H-N, Igarashi A, Zhang Q, Abbadi S, Amzel LM, Sesaki H, Quinones-Hinojosa A and Iijima M. 2017. Characterization of PTEN mutations in brain cancer reveals that PTEN mono-ubiquitination promotes protein stability and nuclear localization. Oncogene. Jun 29;36(26):3673-3685. doi: 10.1038/onc.2016.493. Epub 2017 Mar 6.
Chung S, Kim S, and Andrew DJ. 2017. Uncoupling apical constriction from tissue invagination. Elife Mar6;6. pii: e22235. doi: 10.7554/eLife.22235. PMCID: PMC5338918
Ewald AJ. 2017. Pulling cells out of tumors. Nat Cell Biol. 2017 Mar 1;19(3):147-149. 
Nakamura H, Inoue T. 2017. Japanese Scientists in Science Signaling 2016. Science Signaling 2017 (In press)
Yang X, Wang H, Ni HM, Xiong A, Wang Z, Sesaki H, Ding WX, Yang L. 2017. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol. 12:264-273
Salka K, Bhuvanendran S, Wilson K, Bozidis P, Mehta M, Rainey K, Sesaki H, Patterson GH, Jaiswal JK, Colberg-Poley AM. 2017. Superresolution imaging identifies that conventional trafficking pathways are not essential for endoplasmic reticulum to outer mitochondrial membrane protein Transport. Sci Rep. 7 (1):16.
Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. 2017. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell 2017;168:264-279
Niu J., Johny M.B., Dick I.E., Inoue T. 2016. Following Optogenetic Dimerizers and Quantitative Prospects. Biophysical Journal 111:1132–1140

2016

Gaus K., Inoue T. 2016. New Biological Frontiers Illuminated by Molecular Sensors and Actuators. Biophysical journal. 2016; 111(6):E01-2.
Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. 2016. Drp1 deficiency leads to Rip3-mediated necroptotic neurodegeneration. Am J Pathol. 186(11):2798-2802.
Ibo M, Srivastava V, Robinson DN, Gagnon Z. Cell blebbing in confined microfluidic environments. PLoS One 2016; 11(10): e0163866.
Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. 2016. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 35:2332-2349. PMCID: PMC5090219
Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, James CD, Molinaro AM, Shieh JT, Phillips JJ. 2016. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016 Nov 29; 7(48):79101-79116
Artemenko Y, Axiotakis L Jr., Borleis J, Iglesias PA, Deveotes PN. 2016. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proc Natl Acad Sci USA. Nov. 22; 113(47):E7500-E7509. PMCID: PMC5127353 [ link ]
Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH. 2016. Protective Effects of Reduced Dynamin-related Protein 1 Against Amyloid Beta-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease. Hum Mol Genet. 25(23):5148-5166.
Gong X, Qian H, Shao W, Li J, Wu J, Li W, Espenshade PJ*, Nieng Y*. 2016. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 26:1197-1211. *Corresponding authors. PMCID: PMC5099872
Kandimalla R, Manczak M, Fry D, Suneetha Y, Sesaki H, Reddy PH. 2016. Reduced Dynamin-related Protein 1 Protects Against Phosphorylated Tau-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease. Hum Mol Genet. 25(22):4881-4897.
Teo WW, Merino V, Cho S, Korangath P, Liang X, Wu R, Neumann NM, Ewald AJ, Sukumar S. 2016.  HOXA5, a regulator of cell fate transition, impedes tumor initiation and progression in breast cancer. Oncogene. 2016 Oct 20; 35(42):5539-5551. 
Kojima R, Kajiura S, Sesaki H, Endo T, Tamura Y. 2016. Identification of multi-copy suppressors for ER-mitochondria tethering proteins in Saccharomyces cerevisiae. FEBS Lett. 2016; Epub ahead of print.  
Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. Drp1 deficiency leads to Rip3-mediated necroptotic neurodegeneration. Am J Pathol. 2016; Epub ahead of print
Adachi Y, Itoh K, Yamada T, Cerveny KL, Suzuki TL, Macdonald P, Frohman MA, Ramachandran R, Iijima M, Sesaki H. Coincident phosphatidic acid interaction restrains Drp1 in mitochondrial division. Mol Cell. 2016;63:1034-43.
Shamir ER, Coutinho K, Auer M, Ewald AJ. 2016. Twist1+ epithelial cells retain adhesive and proliferative capacity during dissemination. Biol Open. 2016 Sep 15; 5 (9):1216-1228. 
Potapova TA, Seidel CW, Box AC, Rancati G, Li R. 2016. Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. Mol Biol Cell. 2016 Oct 15;27(20):3065-3084. Epub 2016 Aug 24.