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Proteins pull together as cells divide (Robinson Lab)

Cytokinesis is a mechanosensitive, fluid dynamical process, and the cytokinesis molecular network is structured like a control system with many feedback loops. The core of this control system is the contractility controller, which has a tremendous dynamic range of force production with about 5-fold coming from myosin II's load sensitivity (reflected in changes in duty ratio) and another 5-7-fold coming from changes in protein concentration. Furthermore, the contractility controller is highly robust, being composed of a group of ‘team-player’ proteins.