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Synthetic Cell Biology: Toward Total Synthesis of Cell Functions (Inoue Lab)
The Inoue Lab develops molecular tools to visualize and re-program cellular processes, and uses these tools to understand complex signaling networks as well as dynamic subcellular entities. In particular, the Inoue Lab has developed chemically-activated switches and fluorescent sensors to explore the assembly and function of the primary cilium, mechanisms of cell locomotion, and regulation of phagocytosis. The insights gained from these studies are now employed to reconstitute cell functions in inert cells or cell-mimetic devices, as part of wide applications in understanding mechanisms in human disease.