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Postdoctoral Fellow

Yoshihiro Adachi, Ph.D.

Yoshihiro Adachi, Ph.D.

Selected Publications:
Kameoka S, Adachi Y, Okamoto K, Iijima M, Sesaki H. 2017. Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics. Trends Cell Biol. [Epub ahead of print].
Adachi Y, Itoh K, Iijima M, Sesaki H. 2017. Assay to measure interactions between purified Drp1 and synthetic liposomes. Bio-Protocol. Vol 7, Iss 9.
Adachi Y, Iijima M, Sesaki H. An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid.  2017 Jun 23:1-8. doi: 10.1080/21541248.2017.1321614. [Epub ahead of print]
Yamada T, Adachi Y, Yanagawa T, Iijima M, Sesaki H. 2017. p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. Neurochem Int. 2017 May 18. pii: S0197-0186(17)30189-4. doi: 10.1016/j.neuint.2017.05.012. [Epub ahead of print]
Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. 2016. Drp1 deficiency leads to Rip3-mediated necroptotic neurodegeneration. Am J Pathol. 186(11):2798-2802.
Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. Drp1 deficiency leads to Rip3-mediated necroptotic neurodegeneration. Am J Pathol. 2016; Epub ahead of print
Adachi Y, Itoh K, Yamada T, Cerveny KL, Suzuki TL, Macdonald P, Frohman MA, Ramachandran R, Iijima M, Sesaki H. Coincident phosphatidic acid interaction restrains Drp1 in mitochondrial division. Mol Cell. 2016;63:1034-43.
Yamada T, Adachi Y, Iijima M, Sesaki H. Making a division apparatus on mitochondria. Trends Biochem Sci. 2016;41:209-210
Zhang, Q., Tamura, Y., Roy, M., Adachi, Y., and Iijima, M., and Sesaki, H. (2014). Biogenesis and roles of phospholipids in mitochondrial fusion, division and mitophagy. Cell Mol. Life Sci. 71: 3767-3778.
Sesaki, H., Adachi, Y., Kageyama, Y., Itoh, K., and Iijima, M. (2014). In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta. 1842: 1179-1185.
Adachi, Y. and Sesaki, H. (2014). Cyclin C: An inducer of mitochondrial division hidden in the nucleus. Developmental Cell. 28: 112-114
Adachi, Y. and Sesaki, H., (2014). Cyclin C: Mitochondrial division inducer hidden in the nucleus. Developmental Cell. 28: 112-114
Sesaki, H., Adachi, Y., Kageyama, Y., Itoh, K., and Iijima, M. (2013). In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta. Epub ahead of print.

Marc Edwards, Ph.D.

Marc Edwards, Ph.D.

Selected Publications:
Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y. 2017. Excitable Signal Transduction Networks in Directed Cell Migration. Annu Rev Cell Dev Biol Oct. 6;33:103-125. Doi: 10.1146/annurev-cellbio-100616-060739. PMID: 28793794
Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN.  2017. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proc Natl Acad Sci USA Aug 28. Pii: 201616600. Doi: 10.1073/pnas.1616600114. [Epub ahead of print]. PMCID: PMC5603988
Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias P, Devreotes PN. 2017.  Altering the threshold of an excitable signal transduction network changes cell migratory modes.  Nat Cell Biol 19:329-340.

Allister Suarez, Ph.D.

Allister Suarez, Ph.D.

Selected Publications:
Nakamura H, Lee AA, Afshar AS, Lin YC, Tanigawa M, Suarez A, Razavi S, DeRose R, Bobb D, Hong W, Gabelli SB, Goutsias J, Inoue T. 2017. Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nature Materials (In press, doi:10.1038/nmat5006)  
Suarez A., Ueno T., Huebner R., McCaffery J.M., and Inoue T.* “Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells” Scientific Reports 4, 4693 (2014)  
Miyamoto T., DeRose R., Suarez A., Ueno T., Chen M., Sun T.-p., Wolfgang M.J., Mukherjee C., Meyers D. and Inoue T. “Generation of Intracellular Logic Gates with Two Orthogonal Chemically Inducible Systems” Nature Chemical Biology (Accepted 2012)

Hiroshi Senoo, Ph.D.

Hiroshi Senoo, Ph.D.

Selected Publications:
Senoo H, Cai H, Wang Y, Sesaki H, Iijima M. The novel racE binding protein GflB sharpens ras activity at the leading edge of migrating cells. Mol Biol Cell. 2016;27(10):1596-605.
Senoo H, Sesaki H, Iijima M. A GPCR handles bacterial sensing in chemotaxis and phagocytosis. Dev Cell. 2016;36:354-356.
Senoo, H. and Iijima, M. Rho GTPase: a molecular compass for directional cell migration. Commun. Integr. Biol. (2014). Epub ahead of print
Nguyen, H-N., Afkari, Y., Senoo, H., Sesaki, H., Devreotes, P.N. and Iijima, M. (2013). Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene, Dec. 2. Doi: 10.1038/onc.2013.507. [Epub ahead of print]. PMID:24292679. PMCID: PMC4041858 [Available on 2015/6/2]
Wang, Y., Senoo, H., Sesaki, H. and Iijima, M. Rho GTPases orient gradient sensing in chemotaxis. Proc. Natl. Acad. Sci. USA. (2013). 110: E4723-32.

Dan Georgess, Ph.D.

Dan Georgess, Ph.D.

Selected Publications:
Asrani K, Sood A, Torres A, Georgess D, Phatak P, Kaur H, Dubin A, Talbot CC Jr, Elhelu L, Ewald AJ, Xiao B, Worley P, Lotan TL. 2017. mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation. J Clin Invest. 2017 Nov 1;127(11):4001-4017. doi: 10.1172/JCI92893. Epub 2017 Sep 25.
Nguyen-Ngoc KV, Silvestri VL, Georgess D, Fairchild AN, Ewald AJ. 2017. Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation. J Cell Sci. 2017 Oct 1;130(19):3213-3221. doi: 10.1242/jcs.208546. Epub 2017 Aug 18.
Xian L, Georgess D, Huso T, Cope L, Belton A, Chang YT, Kuang W, Zhang X, Senger S, Fassano A, Huso DL, Ewald AJ, Resar LMS. 2017. HMGA1 Amplifies Wnt Signaling and Expands the Intestinal Stem Cell Compartment and Paneth Cell Niche. Nat Communications, 2017 Apr 28;8:15008

Michael Wells, Ph.D.

Michael Wells, Ph.D.

Selected Publications:
Wells MB, Villamor J, and Andrew DJ. Salivary gland maturation and duct formation in the African malaria mosquito Anopheles gambiae. 2017. Scientific Reports 7:601. DOI: 10.1038/s41598-017-00672-0.
Loganathan R, Lee JS, Wells MB, Grevengood E, Slattery M, Andrew DJ. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol. 2016 Jan 1;409(1):234-50
Wells, M.B. and Andrew, D.J. (2015) Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensiParasites and Vectors.  In press.  

Rajprasad Loganathan, Ph.D.

Rajprasad Loganathan, Ph.D.

Selected Publications:
Loganathan R, Lee JS, Wells MB, Grevengood E, Slattery M, Andrew DJ. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol. 2016 Jan 1;409(1):234-50
Loganathan, R., Cheng, Y.L. and Andrew, D.J. (2015) ­Development of the Drosophila Respiratory System.  In:  Organogenetics.  Springer.  In press.

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