Research Topic: Signaling, cell-cell interaction, intercellular communication, immune cell activation, multi-dimensional imaging, novel biosensors
The long-term goal of our studies is to understand the complex cellular and molecular mechanisms of…
Research Topic : Progeria and lamin A processing by the ZMPSTE24 protease; ERAD and cytosolic protein quality control; yeast and mammalian cell biology.
The overall goal of our research is to…
Research Summary
Multi-cellular living organisms grow from single cells into multicellular, complex systems composed of highly diverse cell-types organized into tissues, which in turn form organs and organ systems. To organize…
Background and Summary
The Ewald Lab seeks to understand how groups of cells cooperate, compete, and interact to organize tissue architecture and function during development and disease progression. Our foundation is…
Research Topic: Trafficking Mechanisms of Copper-ATPases in Polarized Epithelial Cells
Epithelia are an important tissue type in the body, because they form selective barriers between the external and internal environments. Of…
Research Topic: Signals Regulating Stem Cell Self-renewal
What are the signals regulating stem cell fate?
A major goal in stem cell biology is to understand how the balance between stem cell renewal…
Research Topic: Regulation of cell migration by cell-ECM adhesion and integrin signaling
Cell migration is essential for a variety of biological events including embryonic development, wound healing, inflammation and the metastasis…
Research Topic: Golgi complex structure/function; intracellular protein trafficking; intracellular virus assembly; coronaviruses; exocytosis of large cargo
We are interested in the structure and function of the Golgi complex, a ubiquitous…
One of the major challenges in cell biology is to understand how biochemical reactions at the molecular scale self-organize to generate physiological forms and functions at the cellular and tissue…
Research Topic: Lipid Signaling Chemotaxis
Mechanisms of gradient sensing and chemotaxis are conserved in mammalian leukocytes and Dictyostelium amoebae. Both cells use G protein linked signaling pathways. PH domains specific for…