Immunotherapy has revolutionized the treatment of cancer. Most modalities of cancer immunotherapy work by enabling cytotoxic CD8 T cells to recognize and kill cancer cells. These cells, however, do not…
Background and Vision
One of nature’s most elegant wonders is embryo development, where numerous cells adopt various fates and organize themselves into a constellation of patterns and shapes generating the intricate…
Further Information
Triggering the body’s defenses to fight cancer.Nautilus, November13 (2021)
Neutrophil extracellular traps may augur severe COVID-19.
The Scientist, May 28 (2020)
Spider-Man’ immune response may promote severe COVID-19.
Scientific American, April 28 (2020)
Why…
Research Summary
Epithelial-to-mesenchymal transition, or EMT, is a major cellular lifestyle change that produces highly invasive cells with the ability to migrate long distances in the body. This process is critical…
The central theme of my research is to understand how mechanical actions feedback to biochemical pathways in cellular processes, and how such mechanochemical crosstalk among key cellular players governs spatial-temporal…
Research topic: Cellular and molecular characterizations of rapid changes during synaptic plasticity
For information processing and integration, neurons undergo rapid cellular and molecular reorganization. Presynaptically, synaptic vesicles undergo fusion with plasma…
Research Topic: Signals Regulating Stem Cell Self-renewal
What are the signals regulating stem cell fate?
A major goal in stem cell biology is to understand how the balance between stem cell renewal…
Research Topic: Cellular regulation of cholesterol homeostasis and adaptation to hypoxia
To maintain homeostasis, cells need to measure the concentration of molecules such as nutrients, reactants, and products. Eukaryotic cells, whether single-cell…
Background and Summary
The Ewald Lab seeks to understand how groups of cells cooperate, compete, and interact to organize tissue architecture and function during development and disease progression. Our foundation is…
Within each human cell is a NUCLEUS, 'mothership' of the human genome and still the least-understood cellular structure. Chromosomes are enclosed by the nuclear envelope (NE) and communicate with the…