Dr. Gould’s research interests lie at the intersection of biochemistry, cell biology, bioengineering, and human disease. At present, our lab is active in four major research areas: (1) elucidating the…
The Fukunaga lab investigates the mechanism and biology of post-transcriptional gene regulation controlled by RNA-binding proteins and small silencing RNAs. Our research projects will answer fundamental biological questions and also…
Immunotherapy has revolutionized the treatment of cancer. Most modalities of cancer immunotherapy work by enabling cytotoxic CD8 T cells to recognize and kill cancer cells. These cells, however, do not…
Unravelling human development with stem cells
During development, numerous cells adopt various fates and organize into a constellation of patterns and shapes generating the intricate body plan. Elucidating the underlying design…
Further Information
Triggering the body’s defenses to fight cancer.Nautilus, November13 (2021)
Neutrophil extracellular traps may augur severe COVID-19.
The Scientist, May 28 (2020)
Spider-Man’ immune response may promote severe COVID-19.
Scientific American, April 28 (2020)
Why…
Research Summary
Epithelial-to-mesenchymal transition, or EMT, is a major cellular lifestyle change that produces highly invasive cells with the ability to migrate long distances in the body. This process is critical…
The central theme of my research is to understand how mechanical actions feedback to biochemical pathways in cellular processes, and how such mechanochemical crosstalk among key cellular players governs spatial-temporal…
Research topic: Cellular and molecular characterizations of rapid changes during synaptic plasticity
For information processing and integration, neurons undergo rapid cellular and molecular reorganization. Presynaptically, synaptic vesicles undergo fusion with plasma…
Research Topic: Lipid Signaling Chemotaxis
Mechanisms of gradient sensing and chemotaxis are conserved in mammalian leukocytes and Dictyostelium amoebae. Both cells use G protein linked signaling pathways. PH domains specific for…
Background and Summary
The Ewald Lab seeks to understand how groups of cells cooperate, compete, and interact to organize tissue architecture and function during development and disease progression. Our foundation is…