Background and Summary
The Ewald Lab seeks to understand how groups of cells cooperate, compete, and interact to organize tissue architecture and function during development and disease progression. Our foundation is…
Research Topic: Signals Regulating Stem Cell Self-renewal
What are the signals regulating stem cell fate?
A major goal in stem cell biology is to understand how the balance between stem cell renewal…
Research Topic: Regulation of nutrient sensing and metabolic homeostasis
Our laboratory’s research focuses on understanding (1) how cells measure levels of available nutrients and (2) how cells adapt to changes in…
Mitochondrial Division and Fusion
Mitochondria are highly dynamic organelles that continually grow, divide, and fuse in tightly regulated ways. These dynamic behaviors are essential for maintaining mitochondrial health, enabling damaged mitochondria…
Research Topic
Synthetic cell biology, driven by hypothesis, technology and curiosity
One of the major challenges in cell biology is to understand how biochemical reactions at the molecular scale self-organize to…
Research Topic: Organogenesis in a model system: Formation of the Drosophila salivary gland and trachea
Tube formation is a ubiquitous process required to sustain life in all multicellular organisms. Tubular organs…
Many cells have an internal “compass” that allows them to detect and move along extracellular chemical gradients in a process referred to as chemotaxis or directed cell migration. In embryogenesis, chemotaxis…
Research Topic : Progeria and lamin A processing by the ZMPSTE24 protease; ERAD and cytosolic protein quality control; yeast and mammalian cell biology.
The overall goal of our research is to…
Research Summary
Multi-cellular living organisms grow from single cells into multicellular, complex systems composed of highly diverse cell-types organized into tissues, which in turn form organs and organ systems. To organize…