Dysfunction of cellular mechanisms maintaining proteostasis leads to accumulation of misfolded proteins and their aggregates, which often results in debilitating human diseases, such as neurodegenerative diseases (ND). Interestingly, those diseases…
As human longevity increases, understanding the mechanisms that drive aging becomes ever more critical. We study the premature aging disorder Hutchinson Gilford Progeria Syndrome to gain molecular insights into aging,…
Cytokinesis is a mechanosensitive, fluid dynamical process, and the cytokinesis molecular network is structured like a control system with many feedback loops. The core of this control system is the…
Among the earliest inputs that cells experienced, mechanical stress (forces) guide and direct behavior of cells, including when they are part of tissues, organs, and organ systems. These mechanical stresses…
The Inoue Lab develops molecular tools to visualize and re-program cellular processes, and uses these tools to understand complex signaling networks as well as dynamic subcellular entities. In particular, the Inoue…
Infective parasites must traverse the mosquito salivary glands to transmit malaria to humans and other animals. The Andrew Lab is leveraging its findings on the molecules required to form and…
Biological oscillations are universally found in nature and are critical at many levels of cellular organization. In the model organism we study, the social amoeba Dictyostelium discoideum, starvation-triggered cell-cell aggregation…
Coronaviruses are enveloped viruses that assemble by budding into the Golgi lumen and then follow the secretory pathway, which is inefficient for such large cargo. These viruses first induce dilation…
To maintain homeostasis, cells need to measure the concentration of molecules such as nutrients, reactants, and products. Eukaryotic cells, whether single-cell fungi or part of a complex human organ, require…
Mitochondria play crucial roles in diverse cellular and physiological processes such as energy production, metabolism, intracellular signaling, cell death, development, and immune response. In these functions, mitochondria serve as a…