Research in the Ewald laboratory starts from a simple question: which cells in a breast tumor are the most dangerous to the patient and most responsible for metastatic disease? To answer this question, we developed novel 3D culture assays to...
Read moreMitochondria play crucial roles in diverse cellular and physiological processes such as energy production, metabolism, intracellular signaling, cell death, development, and immune response. In these functions, mitochondria serve as a bioenergetic...
Read moreTo maintain homeostasis, cells need to measure the concentration of molecules such as nutrients, reactants, and products. Eukaryotic cells, whether single-cell fungi or part of a complex human organ, require environmental oxygen for essential...
Read moreBiological oscillations are universally found in nature and are critical at many levels of cellular organization. In the model organism we study, the social amoeba Dictyostelium discoideum, starvation-triggered cell-cell aggregation and...
Read moreAmong the earliest inputs that cells experienced, mechanical stress (forces) guide and direct behavior of cells, including when they are part of tissues, organs, and organ systems. These mechanical stresses are propagated through the cell’s skin...
Read moreCytokinesis is a mechanosensitive, fluid dynamical process, and the cytokinesis molecular network is structured like a control system with many feedback loops. The core of this control system is the contractility controller, which has a...
Read moreInfective parasites must traverse the mosquito salivary glands to transmit malaria to humans and other animals. The Andrew Lab is leveraging its findings on the molecules required to form and maintain the Drosophila salivary gland to develop...
Read moreThe Inoue Lab develops molecular tools to visualize and re-program cellular processes, and uses these tools to understand complex signaling networks as well as dynamic subcellular entities. In particular, the Inoue Lab has developed...
Read moreDysfunction of cellular mechanisms maintaining proteostasis leads to accumulation of misfolded proteins and their aggregates, which often results in debilitating human diseases, such as neurodegenerative diseases (ND). Interestingly, those...
Read moreCoronaviruses are enveloped viruses that assemble by budding into the Golgi lumen and then follow the secretory pathway, which is inefficient for such large cargo. These viruses first induce dilation of Golgi cisternae and then modulate the...
Read moreAs human longevity increases, understanding the mechanisms that drive aging becomes ever more critical. We study the premature aging disorder Hutchinson Gilford Progeria Syndrome to gain molecular insights into aging, focusing on the nuclear...
Read moreMany adult tissues are renewed from small populations of stem cells, which continually replace differentiated cells lost to damage or age. Since tissue stem cells are highly dependent on signals from their local microenvironments, or niches...
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