Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

Wang, Y., Shilagardi, K., Hsu, T., Odinammadu, K.O., Maruyama, T., Wu, W., Lin, C-S., Damoci, C. B., Spear, E. D., Shin, J.-Y.  Hsu, W. Michaelis, S.*, and Worman, H.J.* (*co-corresponding authors) (2022).  Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice. Proc. Natl. Acad. Sci. USA 119: e2118695119. doi: 10.1073/pnas.2118695119. PMID: 35197292; PMCID: PMC8892526