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Recent Publications

A listing of publications from the last 12 months...

2020

Raynor J, Liu C, Dhungana Y, Guy C, Chapman N, Shi H, Neale G, Sesaki H, Chi H. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020. In press.  
Jin, Q., Bhatt, A., Pagaduan, P.V., Chen, X., West-Foyle, H., Liu, J., Hou, A., Berkowitz, D., Kuo, S.C., Askin, F.B., Nguyen, T.D., Gracias, D.H., and Romer, L. (2020) Biomimetic human small muscular pulmonary arteries.  Sci. Adv., in press  
Murata D, Arai K, Iijima M, Sesaki H. Mitochondrial Division, Fusion and Degradation. J Biochem. 2020;167:233-241  
Zhou Z, Torres M, H Sha, Halbrook CJ., Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter A, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard D, Qi L. Regulation of endoplasmic reticulum-mitochondria contacts and mitochondrial dynamics by Sel1L-Hrd1 ERAD during thermogenesis. Science. 2020. In press.  
Wang H, Li Y, Yang J, Duan X, Kalab P, Sun S, and Li R. Symmetry breaking in hydrodynamic forces drive meiotic spindle rotation in mammalian oocyte. Sci Adv Advance In press  
Srivastava V, Balaban AE. Robinson DN.* Cytokinesis. In Joseph Jez (ed) The Encyclopedia of Biological Chemistry 3rd Edition, 2020; Academic Press, Waltham, MA., In press.  
Hinge A, He J, Bartram J, Javier J, Xu J, Fjellman E, Sesaki H, Li T, Yu J, Wunderlich M, Mulloy J, Kofron M, Salomonis N, Grimes HL, Filippi MD. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020 Mar 5;26(3):420-430  
Hasnain Z, Fraser AK, Georgess D, Choi A, Macklin P, Bader JS, Peyton SR, Ewald AJ, Newton PK. OrgDyn: Feature and Model Based Characterization of Spatial and Temporal Organoid Dynamics. Bioinformatics 2020 Feb 24[Online ahead of print]. DOI: 10.1093/bioinformatics/btaa096.
Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, Devreotes PN (2020). Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proc Natl Acad Sci U S A, 117(8), 4158-4168. doi: 10.1073/pnas.1917938117.  
Crews DC, Wilson KL, Sohn J, Kabacoff CM, Poynton SL, Murphy LR, Bolz J, Wolfe A, White PT, Will C, Collins C, Gauda E, Robinson DN*. Helping scholars overcome socioeconomic barriers to medical and biomedical careers: Creating a pipeline initiative.  Teach. Learn. Med. 2020; 1-12. DOI: 10.1080/10401334.2020.1729161.  
Pei-Hsun Wu*, Daniele M. Gilkes, Jude M. Phillip, Akshay Narkar, Thomas Wen-Tao Cheng, Jorge Marchand, Meng-Horng Lee, Rong Li, Denis Wirtz*. 2020. Single-cell morphology encodes metastatic potential. Sci. Adv. 6, eaaw6938 (2020) DOI: 10.1126/sciadv.aaw6938
Padmanaban V, Tsehay Y, Cheung KJ, Ewald AJ, Bader JS. Between-tumor and Within-Tumor Heterogeneity in Invasive Potential. PLOS Comput Biol, 16 (1), e1007464, 2020 Jan 21.    
Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ. Twist1-induced epithelial dissemination requires Prkd1signaling. Cancer Res, 2020 Jan 15, 80 (2), 204-218. 
Duan X, Li Y, Yi K, Guo F, Wang H, Wu PH, Yang J, Mair DB, Morales EA, Kalab P, Wirtz D, Sun SX, Li R. Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes. Nat Commun. 2020 Jan 14;11(1):277. doi: 10.1038/s41467-019-14068-3.  
Ruan L, Wang Y, Zhang X, Tomaszewski A, McNamara JT, Li R. 2020. Mitochondria-associated proteostasis. Ann Rev Biophys. 2020 Jan 13. doi: 10.1146/annurev-biophys-121219-081604. [Epub ahead of print].  

2019

Yang J, Duan X, Fraser AK, Choudhury MI, Ewald AJ, Li R, Sun SX. Microscale Pressure Measurements Based on an Immiscible Fluid/Fluid Interface. Sci Rep. 2019 Dec 27;9(1):20044. doi: 10.1038/s41598-019-56573-x.  
Cao Y, Ghabache E, Miao Y, Niman C, Hakozaki H, Reck-Peterson SL, Devreotes PN, and Rappel W-J.  2019. A minimal computational model for three-dimensional cell migration. J. R. Soc. Interface 16:20190619. http://dx.doi.org/10.1098/rsif.2019.0619  
Pal DS*, Li X*, Banerjee T, Miao Y, Devreotes PN. 2019. The Excitable Signal Transduction Networks: Movers and Shapers of Eukaryotic Cell Migration. Int. J. Dev. Biol. 63(8-9-10):407-416. doi: 10.1387/ijdb.190265pd. *Equal contribution.
Li X, Miao Y, Pal DS, Devreotes PN. Excitable networks controlling cell migration during development and disease. Semin Cell Dev Biol. 2019 Dec 10;. doi: 10.1016/j.semcdb.2019.11.001. [Epub ahead of print] Review. PubMed PMID: 31836289; NIHMSID:NIHMS1546309  
Thompson DJ et al. Genetic predisposition to mosaic Y chromosome loss in blood. Nature. 2019 Nov;575(7784):652-657. doi: 10.1038/s41586-019-1765-3. Epub 2019 Nov 20.
Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Rep. 2019 Nov 5;29(6):1511-1523.
Li R. I am an American scientist of the world. Mol Biol Cell. 2019 Nov 1;30(23):2865-2866. doi: 10.1091/mbc.E19-07-0389.
Devreotes P (2019). Moving toward molecular mechanisms for chemotaxis in eukaryotic cells. Mol Biol Cell, 30(23), 2873-2877, 2019 Nov 1. doi: 10.1091/mbc.E19-07-0393. PMC6822590.
Itoh K, Murata D, Kato T, Yamada T, Araki Y, Saito A, Adachi Y, Igarashi A, Li S, Pletnikov M, Huganir RL, Watanabe S, Kamiya A, Iijima M, Sesaki H. Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. Elife. 2019 Oct 11;8. pii: e44739.  
Drutovic D, Duan X, Li R, Kalab P, Solc P. RanGTP and Importin β Regulate Meiosis I Spindle Assembly and Function in Mouse Oocytes. EMBO J. 2020 Jan 2;39(1):e101689. doi: 10.15252/embj.2019101689. Epub 2019 Oct 16.  
Puddu F, Herzog M, Selivanova A, Wang S, Zhu J, Klein-Lavi S, Gordon M, Meirman R, Millan-Zambrano G, Ayestaran I, Salguero I, Sharan R, Li R, Kupiec M, Jackson SP. Genome Architecture and Stability in the Saccharomyces Cerevisiae Knockout Collection. Nature 2019 Sep;573(7774):416-420. doi: 10.1038/s41586-019-1549-9. Epub 2019 Sep 11.      
Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN. Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14. Cancer Res. 2019; 79: 4665-4678.  
Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN. How the mechanobiome drives cell behavior, viewed through the lens of control theory. J. Cell Sci. 2019; 132:1-10. jcs234476.  
Spear, E.D, Alford, R.F., Babatz, T.D., Wood, K., Mossberg, O.  Shilgardi, K., Odinammadu, K Gray, J., and Michaelis, S. (2019) A Humanized Yeast System to Analyze Cleavage of Prelamin A by ZMPSTE24. Methods 157:47-55
Nakamura H, DeRose R, Inoue T. “Harnessing biomolecular condensates in living cells” Journal of Biochemistry (in press, 2019)  
Wells, M.B. and Andrew, D.J. (2019). Anopheles Salivary Gland Architecture Shapes Plasmodium Sporozoite Availability for Transmission. mBio. 2019 Aug 6;10(4):e01238-19. doi: 10.1128/mBio.01238-19.PMID: 31387905.
Johnson, D.M. and Andrew, D.J. (2019) Role of tbc1 in Drosophila embryonic salivary glands.  BMC Cell and Molec. Biol  20:19  
Suresh, K., K. Carino, L. Johnston, L. Servinsky, C. Machamer, T. Kolb, H. Lam, S. Dudek, S. An, M. Rane, L. Shimoda, and M. Damarla. 2019. A non-apoptotic, endothelial barrier-protective role for caspase 3. Amer. J. Physiol. Lung 316)6):L1118-L1126. 
Westerbeck, J.W. and C.E. Machamer. 2019. The infectious bronchitis virus coronavirus envelope protein alters Golgi pH to protect spike protein and promote release of infectious virus. J. Virol.93(11):1-15. PMCID: PMC6532078
Padmanaban V, Suhail Y, Bader JS, Ewald AJ, "E-cadherin suppresses invasion and promotes metastasis in multiple breast cancer models," Accepted in Principle at Nature, 2019.  
Adachi Y, Iijima M, Sesaki H. An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid. Small GTPases. 2018 Nov 2;9(6):472-479.  
Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer and David F. Kashatus. Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth. Cell Reports. In press  
Yamada T, Dawson TM, Yanagawa T, Iijima M, Sesaki H. SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy. Autophagy. 2019; In press.
Michael P. Catanzaro, Ashley Weiner, Amanda Kaminaris, Fei Cai, Cairong Li, Fengyi Zhao, Satoru Kobayashi, Tamayo Kobayashi, Yuan Huang, Hiromi Sesaki, Qiangrong Liang. Doxorubicin-induced Cardiomyocyte Death is Mediated by Unchecked Mitochondrial Fission and Mitophagy. FASEB J. In press.  
Senoo H, Kamimura K, Kimura R, Nakajima A, Sawai S, Sesaki H, Iijima M. Phosphorylated Rho-GDP directly activates mTORC2 Kinase toward AKT through dimerization with Ras-GTP to regulate cell migration. Nature Cell Biology. 2019; Epub ahead of Print  
Arun A, Eddings CR and Wilson KL (2019) Novel missense alleles of SIGMAR1 as tools to understand emerin-dependent gene silencing in response to cocaine. Exp. Biology & Medicine (in press) 
Surcel A, Robinson DN.* Meddling with myosin’s mechanobiology in cancer. Proc. Natl. Acad. Sci. U.S.A. 2019; 116(31): 15322-15323.