Eric Spear, Ph.D.

Research Associate (Michaelis Lab)

410-955-8286

Department of Cell Biology
Johns Hopkins University School of Medicine
725 N. Wolfe Street, 106 Biophysics
Baltimore, MD 21205


Current Lab

Michaelis Lab

Publications

  • Babatz, T.D., Spear, E. D, Xu, W., Sun, O. L., Nie, L., Carpenter. E.P., and Michaelis, S. (2020) Site Specificity Determinants for Prelamin A Cleavage by the Zinc Metalloprotease ZMPSTE24. J. Biol. Chem. (In Press)
  • Wood, K., Spear, E.D., Mossberg, O.W., Odinammadu, K., Xu, W., and Michaelis, S. (2020) Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.  PLOS ONE (In Press)

  • Spear, E.D, Alford, R.F., Babatz, T.D., Wood, K., Mossberg, O.  Shilgardi, K., Odinammadu, K Gray, J., and Michaelis, S. (2019) A Humanized Yeast System to Analyze Cleavage of Prelamin A by ZMPSTE24. Methods 157:47-55

  • Spear E. D,. Hsu E.-T., Nie L., Carpenter E.P., Hrycyna C.A., and Michaelis S. (2018). ZMPSTE24 Missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or  protein stability.  Disease Models and Mechanism 11:1-12 PMID 29794150

  • Maurer, M.J., Spear, E.D., Yu, A.T., Lee, E.J., Shahzad, S, and Michaelis, S.  (2016)  Degradation signals for ubiquitin-proteasome dependent cytosolic protein quality control (CytoQC) in yeast. G3:Genes, Genomes, Genetics 6:1853-66, PMC4938640.