Department of Cell Biology
Johns Hopkins University School of Medicine
725 N. Wolfe Street, 106 Biophysics
Baltimore, MD 21205
Publications
Babatz, T.D., Spear, E. D, Xu, W., Sun, O. L., Nie, L., Carpenter. E.P., and Michaelis, S. (2020) Site Specificity Determinants for Prelamin A Cleavage by the Zinc Metalloprotease ZMPSTE24. J. Biol. Chem. 2021 Jan-Jun; 296:100165. doi: 10.1074/jbc.RA120.015792. Epub 2020 Dec 11. PMID: 33293369; PMCID: PMC7948416
Wood, K., Spear, E.D., Mossberg, O.W., Odinammadu, K., Xu, W., and Michaelis, S. (2020) Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24. PLOS ONE 15(12): e0239269. PMID: 33315887 PMCID: PMC7735620
Spear, E.D, Alford, R.F., Babatz, T.D., Wood, K., Mossberg, O. Shilgardi, K., Odinammadu, K Gray, J., and Michaelis, S. (2019) A Humanized Yeast System to Analyze Cleavage of Prelamin A by ZMPSTE24. Methods 157:47-55
Spear E. D,. Hsu E.-T., Nie L., Carpenter E.P., Hrycyna C.A., and Michaelis S. (2018). ZMPSTE24 Missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability. Disease Models and Mechanism 11:1-12 PMID 29794150
Maurer, M.J., Spear, E.D., Yu, A.T., Lee, E.J., Shahzad, S, and Michaelis, S. (2016) Degradation signals for ubiquitin-proteasome dependent cytosolic protein quality control (CytoQC) in yeast. G3:Genes, Genomes, Genetics 6:1853-66, PMC4938640.
