Research

Catching neurons in action: molecular mechanisms of synaptic transmission and plasticity (Watanabe Lab)

Neurons communicate with each other through chemical signals that are released from one nerve terminal (pre-synapse) and received...

Cells can count (Devreotes Lab)

Biological oscillations are universally found in nature and are critical at many levels of cellular organization. In the...

Cells Catch their Breath (Espenshade Lab)

To maintain homeostasis, cells need to measure the concentration of molecules such as nutrients, reactants, and products. Eukaryotic...

Controlling Tumor Suppressor PTEN (Iijima Lab)

Mutations and deletions in the gene encoding phosphatase and tensin homolog (PTEN) deleted from chromosome 10 are associated...

Coronaviruses trick the Golgi complex (Machamer lab)

Coronaviruses are enveloped viruses that assemble by budding into the Golgi lumen and then follow the secretory pathway,...

Finding your niche (Matunis Lab)

Many adult tissues are renewed from small populations of stem cells, which continually replace differentiated cells lost to...

Follow the Leader: Specialized Cancer Cells Lead Collective Invasion (Ewald Lab)

Research in the Ewald laboratory starts from a simple question: which cells in a breast tumor are the...

It’s MAGIC: Mitochondria take care of the misfolded proteins from cytosol (Li Lab)

Dysfunction of cellular mechanisms maintaining proteostasis leads to accumulation of misfolded proteins and their aggregates, which often results...

Mitochondria in the Brain (Sesaki Lab)

Mitochondria play crucial roles in diverse cellular and physiological processes such as energy production, metabolism, intracellular signaling,...

Molecular Mechanisms of Cellular Mechanosensing (Robinson Lab)

Among the earliest inputs that cells experienced, mechanical stress (forces) guide and direct behavior of cells, including when...

Mothership of the Human Genome (Wilson Lab)

The cell nucleus surrounds, organizes and mechanically protects the genome. Lamin filament networks and nuclear membrane proteins support...

Proteins pull together as cells divide (Robinson Lab)

Cytokinesis is a mechanosensitive, fluid dynamical process, and the cytokinesis molecular network is structured like a control system...

Synthetic Cell Biology: Toward Total Synthesis of Cell Functions (Inoue Lab)

The Inoue Lab develops molecular tools to visualize and re-program cellular processes, and uses these tools to understand...

The Mosquito Salivary Gland: A Gateway Organ for Parasite Transmission (Andrew Lab)

Infective parasites must traverse the mosquito salivary glands to transmit malaria to humans and other animals. The Andrew...

When the young die old (Michaelis Lab)

As human longevity increases, understanding the mechanisms that drive aging becomes ever more critical. We study the premature...