Lin Y, Pal DS, Banerjee P, Banerjee T, Qin G, Deng Y, Borleis J, Iglesias PA and Devreotes P. 2023. BioRxiv 09-01-2023. https://www. (preprint).  doi:10.1101/2023.08.30.555648

Pal DS, Lin Y, Zhan H, Banerjee T, Kuhn J, Providence S and Devreotes PN. 2023. Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement. Front Cell Dev Biol 11:1195806. doi: 10.3389/fcell.2023.1195806

Pal DS*, Banerjee T, Lin Y, de Trogoff F, Borleis J, Iglesias PA, Devreotes PN*. 2023. Actuation of single downstream nodes in growth factor network steers immune cell migration. Dev Cell May 22. Online ahead of print.

Kim AK, Wu HD, Inoue T “Synthetic design of farnesyl-electrostatic peptides for development of a protein kinase A membrane translocation switch” Scientific Reports 2021;11:16421

Nakamura H, Rho E, Deng D, Razavi S, Matsubayashi HT, Inoue T “ActuAtor, a molecular tool for generating force in living cells” bioRxiv03.30.016360

Balaban AE, Nguyen LTS, Parajón E, and Robinson DN*. Non-muscle myosin IIB is a driver of cellular reprogramming. Biol. Cell, 2023; In press. DOI: 10.1091/mbc.E21-08-0386.

Ogunmowo, T., Jing, H., Raychaudhuri, S., Kusick, G.F., Imoto, Y., Ma, Y., Jafri, H., Dalva, M., Chapman, E.R., Ha, T., Watanabe, S.*, Liu, J.*, Membrane compression by exocytosis triggers ultrafast endocytosis, 2023, in press. BioRxiV, DOI: 10.1101/2022.06.12.495801

Banerjee T, Matsuoka S, Biswas D, Miao Y, Pal DS, Kamimura Y, Ueda M, Devreotes PN and Iglesias PA. 2023. A dynamic partitioning mechanism polarizes membrane protein distribution. bioRxiv 01-03-23. doi: 10.1101/2023.01.03.522496.

Yang Q, Miao Y, Banerjee P, Hourwitz MJ, Hu M, Qing Q, Iglesias PA, Devreotes PN, Fourkas JG and Losert W. 2022. Nanotopography modulates intracellular excitable systems through cytoskeleton actuation. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2218906120. doi: 10.1073/ pnas.2218906120. Epub 2023 May 1.

Neil M. Neumann, Daniel M. Kim, Robert J. Huebner and Andrew J. Ewald*Collective cell migration is spatiotemporally regulated during mammary epithelial bifurcation. © 2023. Published by The Company of Biologists Ltd | Journal of Cell Science (2023) 136, jcs259275. doi:10.1242/jcs.259275


Pal DS, Banerjee T, Lin Y, Borleis J and Devreotes PN. 2022. Direct activation of the Ras-Akt network mediates polarity and organizes protrusions in human neutrophil migration. bioRxiv 10-28-22. (preprint).

Greenspan, L.J., de Cuevas, M, Le, K.H. Viveiros, J.M. and Matunis, E.L. Activation of the EGFR/MAPK pathway drives transdifferentiation of quiescent niche cells to stem cells in the Drosophila testis Elife. 2022 Apr 25;11:e70810. doi: 10.7554/eLife.70810.PMID: 35468055.

Hongjie Li, Jasper Janssens, Maxime De Waegeneer, Sai Saroja Kolluru, Kristofer Davie, Vincent Gardeux, Wouter Saelens, Fabrice David, Maria Brbić, Jure Leskovec, Colleen N. McLaughlin, Qijing Xie, Robert C. Jones, Katja Brueckner, Jiwon Shim, Sudhir Gopal Tattikota, Frank Schnorrer, Katja Rust, Todd G. Nystul, Zita Carvalho-Santos, Carlos Ribeiro, Soumitra Pal, Teresa M. Przytycka, Aaron M. Allen, Stephen F. Goodwin, Cameron W. Berry, Margaret T. Fuller, Helen White-Cooper, Erika L. Matunis, Stephen DiNardo, Anthony Galenza, Lucy Erin O’Brien, Julian A. T. Dow, FCA Consortium, Heinrich Jasper, Brian Oliver, Norbert Perrimon, Bart Deplancke, Stephen R. Quake, Liqun Luo, Stein Aerts. Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit flyScience. 2022 Mar 4;375(6584):eabk2432. doi: 10.1126/science.abk2432. Epub 2022 Mar 4. PMID: 35239393.

Mahadevaraju, S., Fear, J., Akeju, M., Galletta, B., Pinheiro, M., Avelino, C., Cabral-de-Mello, D., Conlon, K., Dell’Orso, S., Demere, Z., Mansuria, K., Mendonca, C., Palacios Giminez, O., Ross, E., Savery, M., Yu, K., Smith, H., Sartorelli V., Nasser, R., Vibranovski, M, Matunis, E. and Oliver, B. Dynamic sex chromosome expression in Drosophila male germ cells. Nat Commun. Feb 9;12(1):892.

Maiorino, L., Shevik, M., Adrover, J.M., Han, X., Georgas, E., Wilkinson, J.E., Seidner, H., Foerschner, L., Tuveson, D.A., Qin, Y.-X., and Egeblad M. (2022) Longitudinal intravital imaging through clear silicone windows. J Vis Exp, 179, e62757, doi:10.3791/6275.

Maiorino, L., Daßler-Plenker, J., Sun, L, and Egeblad, M. (2022) Innate Immunity and Cancer Pathophysiology. Annu Rev Pathol. 2021. doi: 10.1146/annurev-pathmechdis-032221-115501.

Adrover, J.M., Carrau, L., Daßler-Plenker, J., Bram, Y., Chandar, V., Houghton, S., Redmond, D., Merrill, J.R., Shevik, M., tenOever, B.R., Lyons, S.K., Schwartz, R.E., and Egeblad M. (2022) Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection. JCI Insight7: e157342.

Quail, D.F., Amulic, B., Aziz, M., Barnes, B.J., Eruslanov, E., Fridlender, Z.G., Goodridge, H.S., Granot, Z., Hidalgo, A., Huttenlocher, A., Kaplan, M.J., Malanchi, I., Merghoub, T., Meylan, E., Mittal, V., Pittet, M.J., Rubio-Ponce, A., Udalova, I.A., van den Berg, T.K., Wagner, D.D., Wang., P., Zychlinsky, A., de Visser, K.E., Egeblad M., Kubes, P. (2022) Neutrophil phenotypes and functions in cancer: a consensus statement J Exp Med , 219(6):e20220011. doi: 10.1084/jem.20220011.

Wu, XS, He, X.-Y., Ipsaro, J.J., Huang, Y.-H., Preall, J.B., Ng, D., Shue, Y.T., Egeblad M., Joshua-Tor, L., and Vakoc, C.R. (2022) OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature doi: 10.1038/s41586-022-04842-7.

Song, D., Adrover, J.M, Felice, C., Christensen, L., He, X.-Y., Merrill, J.R., Wilkinson, J.E., Janowitz, T. Lyons, S.K., Egeblad M., and Tonks, N.K. (2022) PTP1B inhibitors regulate the CXCR4-CXCR2 signaling axis in neutrophils and protect against acute lung injury. JCI Insight 7(14):e158199. doi: 10.1172/jci.insight.158199.

Olsen T., Caruana D., Cheslack-Postava K., Szema A., Thieme J., Kiss A., Singh M., Smith G., McClain S., Glotch T., Esposito M., Promisloff R., Ng D., He X., Egeblad M., Kew R., Szema A. (2022) Iraq/Afghanistan war lung injury reflects burn pits exposure. Sci Rep. 12(1):14671. doi: 10.1038/s41598-022-18252-2.

Banerjee T, Biswas D*, Pal DS*, Miao Y, Iglesias PA and Devreotes PN. 2022. Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Nat Cell Biol. 2022 Oct;24(10):1499-1515. doi: 10.1038/s41556-022-00997-7. Epub 2022 Oct 6. PMC10029748. *Co-second Authors.

Yang Q, Miao Y, Campanello LJ, Hourwitz MJ, Bull AL, Devreotes PN, FourkasJT and Losert W. 2022. Cortical waves mediate the cellular response to electric fields. Elife. 2022 Mar 23;11:e73198. doi: 10.7554/eLife.73198. PMC8942472.

Pascini TV, Jeong YJ, Huang W, Pala ZR, Sá JM, Wells MB, Kizito C, Sweeney B, Alves E Silva TL, Andrew DJ, Jacobs-Lorena M, Vega-Rodríguez J. Nat Commun. 2022 May 26;13(1):2949. doi: 10.1038/s41467-022-30606-y.PMID: 35618711

Loganathan R, Levings DC, Kim JH, Wells MB, Chiu H, Wu Y, Slattery M, Andrew DJ. J Cell Biol. 2022 Apr 4;221(4):e202110073. doi: 10.1083/jcb.202110073. Epub 2022 Feb 23.PMID: 35195669

Taracena M, Hunt C, Pennington P, Andrew D, Jacobs-Lorena M, Dotson E, Wells M. J Vis Exp. 2022 Mar 1;(181). doi: 10.3791/63266.PMID: 35311819

Loganathan R, Kim JH, Wells MB, Andrew DJ. Curr Top Dev Biol. 2021;143:1-36. doi: 10.1016/bs.ctdb.2020.09.005. Epub 2020 Nov 19.PMID: 33820619

Chiu MZ, Lannon S, Luchetti M, Wells MB, Andrew DJ. J Vis Exp. 2021 Sep 30;(175). doi: 10.3791/62989.PMID: 34661579

Chung S, Le TP, Vishwakarma V, Cheng YL, Andrew DJ. Genetics. 2021 Oct 2;219(2):iyab100. doi: 10.1093/genetics/iyab100.PMID: 34173831

Watanabe S, Nihongaki Y, Itoh K, Watanabe S, Inoue T “Defunctionalizing Intracellular Organelles with Genetically-Encoded Molecular Tools Based on Engineered Phospholipase A/Acyltransferases” Nature Communications 2022;13:4413:1-15

Deb Roy A, Gross EG, Pillai GS, Seetharaman S, Etienne-Manneville S, Inoue T “Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation” Journal of Cell Biology 2022;221:11:e1-20

Matsubayashi HT, Mountain J, Yao T, Peterson AF, Deb Roy A, Inoue T “Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis” bioRxiv, 2022.12.31.522383

Plaza- Rodriguez a., Nguyen LTS, Robinson DN, Iglesias, PA. Particle-based model of mechanosensory contractility kit assembly. Biophys. J. 2022; 121: 1-15. DOI:

Nguyen LTS and Robinson DN*. The lectin Discoidin I acts in the cytoplasm to help assemble the contractile machinery. Cell Biol. 2022; 221(11):e202202063. DOI:

Nguyen LTS, Jacob MAC, Parajón E, and Robinson DN*. Cancer as a biophysical disease: targeting the mechanical-adaptability program. J. 2022; 121(19): 3573-3585. DOI:

Angstadt S, Zhu Q, Jaffee EM, Robinson DN*, and Anders RA*. Pancreatic ductal adenocarcinoma cortical mechanics and clinical implications. Frontiers in Oncology, 2022; 12: 1-15.

Imoto, Y., Raychaudhuri, S.*, Ma, Y.*, Fenske, P., Sandoval, E., Itoh, K., Blumrich, E., Matsubayashi, H.T.,  Mamer, L., Zarebidaki, F., Söhl-Kielczynski, B., Trimbuch, T., Nayak, Shraddha, Iwasa, J., Liu, J., Wu, B., Ha, T., Inoue, T., Jorgensen, E.M., Cousin, M., Rosenmund, C., Watanabe, S., (2022), Dynamin is primed at endocytic sites for ultrafast endocytosis, Neuron, S0896-6273(22)00548-7.

Elodie Henriet1, Hildur Knutsdottir2, Eloise M. Grasset1, Matthew Dunworth1, Meagan Haynes1, Joel S. Bader2,3 and Andrew J. Ewald. Triple negative breast tumors contain heterogeneous cancer cells expressing distinct KRAS-dependent collective and disseminative invasion programs. © The Author(s), under exclusive licence to Springer Nature Limited 2022


Ghabache E, Cao Y, Miao Y, Groisman A, Devreotes PN and Rappel W-J. 2021. Coupling traction force patterns and actomyosin wave dynamics reveals mechanics of cell motion. Mol Sys Biol. 2021;17:e10505. doi: 10.15252/msb.202110505.

Kuhn J, Lin Y and Devreotes PN. 2021. Using live-cell imaging and synthetic biology to probe directed migration in Dictyostelium. Front. Cell Dev Biol. 2021 Oct 05. doi: 10.3389/fcell.2021.740205.

Biswas D, Devreotes PN and Iglesias PA. 2021. Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells. PLoS Comput Biol. 2021 Jul 14;17(7):e1008803. PMC8330952. doi: 10.1371/journal.pcbi.1008803. eCollection 2021 Jul.

Senoo H, Murata D, Wai M, Arai K, Iwata W, Sesaki H, Iijima M. (2021). KARATE: Protein kinase A-induced KRAS4B-RHOA-mTORC2 supercomplex that phosphorylates AKT in insulin signaling and glucose homeostasis. Mol. Cell. In press.

Fujii T., Rehman H., Chung S.Y., Shen J., Newman J., Wu V., Hines A., Azimi-Nekoo E., Fayyaz F., Lee M., Raptis G., Egeblad M., and Zhu X. (2021) Treatment with Granulocyte-colony Stimulating Factor (G-CSF) is not associated with Increased Risk of Brain Metastasis in Patients with De Novo Stage IV Breast Cancer. J Cancer. 12:5687-5692. doi: 10.7150/jca.63159. eCollection 2021.


Sun L., Kees T., Almeida A.S., Liu B., He X.Y., Ng D., Han X., Spector D.L., McNeish I.A., Gimotty P., Adams S., and Egeblad M. (2021) Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis. Cancer Cell, 39, 1361-1374.

Barth N.D., Mendive-Tapia L., Subiros-Funosas R., Ghashghaei O., Lavilla R., Maiorino L., He X.Y., Dransfield I., Egeblad M., and Vendrell M. (2021) A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy-Induced Cancer Cell Death. Angew Chem Int Ed Engl. doi: 10.1002/anie.202113020.

Song B, Gu Y, Jiang W, Li Y, Ayre WN, Liu Z, Yin T, Janetopoulos C, Iijima M, Devreotes P, Zhao M. 2021. Electric signals counterbalanced posterior vs. anterior PTEN signaling in directed cell migration of Dictyostelium. Cell Biosci. 2021 Jun 14;11(1):111. PMC8201722.

Nihongaki Y, Matsubayashi HT, Inoue T. “A molecular trap inside microtubules probes luminal access by soluble proteins” Nature Chemical Biology 2021;17:888-895

Srivastava V, Balaban AE. Robinson DN.* In Joseph Jez (ed) The Encyclopedia of Biological Chemistry 3rd Edition, 2021; Oxford: Elsevier. Vol. 5, pp. 42-48.

DiNapoli, KT, Robinson DN, Iglesias PA. A mesoscale mechanical model of cellular interactions. J. 2021; 120: 4905-4917. DOI:

Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial metabolism, surface hydration, and ciliary function. J. Cell Sci. 2021; 134(4): jcs257162.

Kim JH, Hanlon CD, Vohra S, Devreotes PN and Andrew DJ. 2021. Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells. Cell Rep. 2021 Mar 2;34(9):108799.  doi: 10.1016/j.celrep.2021.108799. PMC8023404.

Li X, Pal DS, Biswas D, Iglesias PA and Devreotes PN. Reverse fountain flow of phospha-tidylinositol-3,4– biphosphate polarizes migrating cells. EMBO J. 2021 Feb 15;40(4):e105094. doi: 10.15252/embj.2020105094.


Wu M, Liu J. Mechanobiology in cortical waves and oscillations. Current Opinions in Cell Biology 2020, Accepted.

McCausland JW, Yang X, Squyres GR,  Lyu Z, Bruce KE, Lamanna MM,  Söderström B, Garner EC, Winkler ME,  Xiao J, Liu J. Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism. Nature Communications 2020, Accepted.

Johnson, D.J. Wells, M.B., Fox, R.M., Lee, J.S., Loganathan, R., Levings, D, Bastien, A., Slattery, M. and Andrew, D.J. (2020) CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators. Traffic 21: 560-577. 

Loganathan, R., Kim, J.H., Wells, M.B., and Andrew, D.J. (2020) Secrets of secretion – How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.  Current Topics in Developmental Biology: Cellular Networks in Development.

Chiu M, Trigg B, Taracena M, and Wells MB. (2020). Diverse cellular morphologies during lumen maturation in Anopheles gambiae larval salivary glands.  Insect Mol Biol.  doi: 10.1111/imb.12689. (Andrew Lab publication)

Wolfe K., Kamata R., Coutinho K., Inoue T. and Sasaki A.T. “Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells” Frontiers in Oncology (in press)

Kim AK, Wu HD, Inoue T, “Rational Design of a Protein Kinase A Nuclear-cytosol Translocation Reporter” Scientific Reports 2020:10:9365

Wu HD, Kikuchi M, Dagliyan O, Aragaki AK, Nakamura H, Dokholyan NV, Umehara T, Inoue T, “Rational design and implementation of a chemically inducible hetero-trimerization system” Nature Methods 17, 928–936 (2020). Note: Research Highlight in Nature Chemical Biology, “Three’s company”

Hanley CJ, Henriet E, Sirka OK, Thomas GJ, Ewald AJ, “Tumor resident stromal cells promote breast cancer invasion through regulation of the basal phenotype,” In Press at Molecular Cancer Research, 2020.

Watanabe, S., Davis, M.W., Kusick, G., Jorgensen, E.M., (2020) SynapsEM: computer-assisted synapse morphometry, Frontiers in Synaptic Neuroscience, DOI: 10.3389/fnsyn.2020.584549.

Kusick, G.F., Chin, M., Raychaudhuri, S., Lippmann, K., Adula, K.P., Hujber, E.J., Vu, T., M. Wayne, Davis, Jorgensen, E.M., and Watanabe, S., (2020) Synaptic vesicles transiently dock to refill release sites, Nature Neurosci., 23, 1329–1338. doi:10.1038/s41593-020-00716-1

Chanaday, N.L., Cousin, M.A., Milosevic, I., Watanabe, S., and Morgan, J.R. (2019) The synaptic vesicle cycle revisited: new insights into the modes and mechanisms, J Neuro., 39(42):8209-8216.

Babatz, T.D., Spear, E. D, Xu, W., Sun, O. L., Nie, L., Carpenter. E.P., and Michaelis, S. (2020) Site Specificity Determinants for Prelamin A Cleavage by the Zinc Metalloprotease ZMPSTE24. J. Biol. Chem. (In Press)

Wood, K., Spear, E.D., Mossberg, O.W., Odinammadu, K., Xu, W., and Michaelis, S. (2020) Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.  PLOS ONE (In Press)

Drutovic P, Duan X, Li R, Kalab P, Solc P. RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes (2020) EMBO J 39:e101689

Wang H, Li Y, Yang J, Duan X, Kalab P, Sun S, and Li R. Symmetry breaking in hydrodynamic forces drive meiotic spindle rotation in mammalian oocyte. (2020) Science Advances 6 DOI:10.1126/sciadv.aaz5004

Ruan L, McNamara JT, Zhang X, Chang AC, Zhu J, Dong Y, Sun G, Peterson A, Chan HN, Li R. Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix. Science Advances 6 DOI:10.1126/sciadv.abc7728

Nguyen J, Liu Y, Nguyen L, Sidhaye VK, Robinson DN*. Discovery and quantitative dissection of cytokinesis using Dictyostelium discoideum. Kimmel A. ed. Methods Mol. Biol. 2021; In press.

Parajón E, Surcel A, Robinson DN*. The Mechanobiome: A Goldmine for Cancer Therapeutics. Am. J. Physiol.-Cell Physiol. 2020; In press. DOI: 10.1152/ajpcell.00409.2020

Nguyen JMK, Robinson DN*, Sidhaye VK*. Why New Biology Must Be Uncovered to Advance Therapeutic Strategies for Chronic Obstructive Pulmonary Disease. Am. J. Phys. Lung Cell Mol. Physiol. 2020; In press. DOI: 10.1152/ajplung.00367.2020

DiNapoli K, Robinson DN, Iglesias PA. Tools for computational analysis of moving boundary problems in cellular mechanobiology.  Wiley Interdiscip Rev Syst Biol Med. 2020 Dec 10; e1514. doi: 10.1002/wsbm.1514.

Senoo H, Wai M, Matsubayashi HT, Sesaki H, Iijima M. Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling. Cell Rep. 2020 Nov 24;33(8):108427

Adachi Y, Kato T, Yamada T, Murata D, Arai K, Stahelin RV, Chan DC, Iijima M, Sesaki H. Drp1 Tubulates the ER in a GTPase-Independent Manner. Mol Cell. 2020 Nov 19;80(4):621-632

Murata D, Yamada T, Tokuyama T, Arai K, Quirós PM, López-Otín C, Iijima M, Sesaki H. Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation. EMBO J. 2020 Nov 17;39(24):e105074

Shao W, Hwang J, Liu C, Mukhopadhyay D, Zhao S, Shen MC, Alpergin ESS, Wolfgang MJ, Farber SA, Espenshade PJ. Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor. J Biol Chem. 2020 Oct 27:jbc.RA120.015238. doi: 10.1074/jbc.RA120.015238. Online ahead of print.

Esquejo RM, Roqueta-Rivera M, Shao W, Phelan PE, Seneviratne U, Am Ende CW, Hershberger PM, Machamer CE, Espenshade PJ, Osborne TF. Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum. Cell Chem Biol. 2020 Oct 20:S2451-9456(20)30382-2. doi: 10.1016/j.chembiol.2020.10.003. Online ahead of print.

Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell K, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau A, Robinson DN. TRPV4 disrupts mitochondrial transport and causes axonal degeneration via CaMKII-dependent elevation of intracellular Ca2+. Nat. Comm. 2020; 11(1):2679. doi: 10.1038/s41467-020-16411-5.

Nguyen L, Robinson DN. The Unusual Suspects in Cytokinesis: Fitting the Pieces Together. Front. Cell Dev. Bio. 2020; 8:441. doi: 10.3389/fcell.2020.00441.

Bryan DS, Stack M, Krystofiak K, Cichoń U, Thomas DG, Surcel A, Schiffhauer ES, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. 4-hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis. Proc. Natl. Acad. Sci. USA. 117 (36)22423-22429. /PDF

Kato T, Yamada T, Nakamura H, Igarashi A, Anders RA, Sesaki H, Iijima M. The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma. iScience. 2020 Sep 10;23(10):101548

Chan IS, Knútsdóttir H, Ramakrishnan G, Padmanaban V, Warrier M, Ramirez JC, Zhang H, Jaffee EM, Bader JS, Ewald AJ, ” Cancer cells educate natural killer cells to a metastasis promoting cell state, Journal of Cell Biology, 2020 Sep 7; 219(9) 10.1083/jcb.202001134.

Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang C-H, Devreotes PN. 2020. An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Dev Cell. 2020 Aug 31;S1534-5807(20)30599-2. doi: 10.1016/j.devcel.2020.08.001.

Bhattacharya S, Banerjee T, Miao Y, Zhan H, Devreotes PN, Iglesias PA. 2020. Traveling and standing waves mediate pattern formation in cellular protrusions.  Science Advances. 2020 Aug 7; 6(32): eaay 7682. doi: 10.1126/sciadv.aay7682.

Yanagi T, Kitamura S, Imafuku K, Suto A, Maeda T, Tanaka S, Sesaki H, Abe R, Shimizu H. Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced  carcinogenesis. J Dermatol Sci. 2020 Aug;99(2):109-118.

Middleton, E.A., He,X.-Y., Denorme, F., Campbell, R.A., Ng, D., Salvatore, S.P., Mostyka, M., Baxter-Stoltzfus, A., Borczuk, A.C., Loda, M., Cody, M.J., Manne, B.K., Portier, I., Harris, E.S., Petrey, A.C., Beswick,E.J., Caulin, A.F., Lovino, A., Abegglen, L.M., Weyrich, A.S., Rondina, M.T., Egeblad M., Schiffman, J.D., and Yost, C.C.(2020). Neutrophil extracellular traps (NETs) contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136:1169-1179.

Dixon E, Maxim DS, Halperin Kuhns VL, Lane-Harris AC, Outeda P, Ewald AJ, Watnick TJ, Welling PA, Woodard OM, “GDNF drives rapid tubule morphogenesis in novel 3D in vitro model for autosomal dominant polycystic kidney disease,” Journal of Cell Science, 2020 Jul 16;133(14):jcs249557.

Silvestri VL, Henriet E, Wong AD, Searson PC*, Ewald AJ*, “An engineered 3D vessel model reveals the dynamics of mosaic vessel formation and collective intravasation”, Cancer Research, 2020 Jul 14;canres.1564.2019.

Sindhwani, S., Syed, A.M., Ngai, J., Kingston, B.R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N.U., Hoang, T., Wu, J.L.Y., Wilhelm, S., Zilman, A., Gadde, S., Sulaiman, A., Ouyang, B., Lin, Z., Wang, L., Egeblad M., and Chan, W.C.W. (2020). The entry of nanoparticles into solid tumours. Nat Mater, 19, 566-575. doi: 10.1038/s41563-019-0566-2.

Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J.A., Blair, C.N., Weber, A., Barnes, B.J., Egeblad M., Woods, R.J., Kanthi, Y., and Knight, J.S. (2020). Neutrophil extracellular traps in COVID-19. JCI Insight, 5:138999. doi: 10.1172/jci.insight.138999.

Somerville, T.D., Biffi, G., Daßler-Plenker, J., Hur, S.K., He, X.Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O.E., Preall, J.B., Hollingsworth, M.A.,Egeblad M., Tuveson, D.A., and Vakoc, C.R. (2020). Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife 9:e53381. doi: 10.7554/eLife.53381.


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Forrester SJ, Preston KJ, Cooper HA, Boyer MJ, Escoto KM, Poltronetti AJ, Elliott KJ, Kuroda R, Miyao M, Sesaki H, Akiyama T, Kimura Y, Rizzo V, Scalia R, Eguchi S. Mitochondrial Fission Mediates Endothelial Inflammation. Hypertension. 2020 Jul;76(1):267-276.

Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB J. 2020 Jun;34(6):8265-8282

Kliment CR, Nguyen JMK, Kaltreider MJ, Lu YW, Claypool SM, Bailey KL, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN*. Adenine Nucleotide Translocase regulates airway epithelial homeostasis, mitochondrial metabolism and ciliary function. bioRxiv. May 19 2020. DOI: 10.1101/2020.05.18.101378

Kim AK, Wu HD, Inoue T “Rational Design of a Protein Kinase A Nuclear-cytosol Translocation Reporter” Scientific Reports 2020;10:9365

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Huang W, Xia L, Jeong YJ, Chianchiano P, Serer BN, Trujilo MA, Lionheart G, Luchini G, Veronese N, Nguyen-Ngoc KV, Neumann NM, Groot VP, Singhi AD, Gaida MM, Wolfgang CL, He J, Thompson ED, Roberts NJ, Ewald AJ, Wood LD, “Pattern of invasion in human pancreatic cancer organoids is associated with Smad4 loss and clinical outcome,” Cancer Res. 2020 May 6. pii: canres.1523.2019.

Hasnain Z, Fraser AJ, Macklin P, Bader JS, Peyton SR, Ewald AJ, Newton PK, “OrgDyn: Feature and model based characterization of spatial and temporal organoid dynamics,” Bioinformatics. 2020 May 1;36(10):3292-3294.

Raynor J, Liu C, Dhungana Y, Guy C, Chapman N, Shi H, Neale G, Sesaki H, Chi H. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020. In press.

Jin, Q., Bhatt, A., Pagaduan, P.V., Chen, X., West-Foyle, H., Liu, J., Hou, A., Berkowitz, D., Kuo, S.C., Askin, F.B., Nguyen, T.D., Gracias, D.H., and Romer, L. (2020) Biomimetic human small muscular pulmonary arteries.  Sci. Adv., in press

Murata D, Arai K, Iijima M, Sesaki H. Mitochondrial Division, Fusion and Degradation. J Biochem. 2020;167:233-241

Zhou Z, Torres M, H Sha, Halbrook CJ., Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter A, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard D, Qi L. Regulation of endoplasmic reticulum-mitochondria contacts and mitochondrial dynamics by Sel1L-Hrd1 ERAD during thermogenesis. Science. 2020. In press.

Wang H, Li Y, Yang J, Duan X, Kalab P, Sun S, and Li R. Symmetry breaking in hydrodynamic forces drive meiotic spindle rotation in mammalian oocyte. Sci Adv Advance In press

Srivastava V, Balaban AE. Robinson DN.* Cytokinesis. In Joseph Jez (ed) The Encyclopedia of Biological Chemistry 3rd Edition, 2020; Academic Press, Waltham, MA., In press.

Hinge A, He J, Bartram J, Javier J, Xu J, Fjellman E, Sesaki H, Li T, Yu J, Wunderlich M, Mulloy J, Kofron M, Salomonis N, Grimes HL, Filippi MD. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020 Mar 5;26(3):420-430

Hasnain Z, Fraser AK, Georgess D, Choi A, Macklin P, Bader JS, Peyton SR, Ewald AJ, Newton PK. OrgDyn: Feature and Model Based Characterization of Spatial and Temporal Organoid Dynamics. Bioinformatics 2020 Feb 24[Online ahead of print]. DOI: 10.1093/bioinformatics/btaa096.

Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, Devreotes PN (2020). Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proc Natl Acad Sci U S A, 117(8), 4158-4168. doi: 10.1073/pnas.1917938117.

Crews DC, Wilson KL, Sohn J, Kabacoff CM, Poynton SL, Murphy LR, Bolz J, Wolfe A, White PT, Will C, Collins C, Gauda E, Robinson DN*. Helping scholars overcome socioeconomic barriers to medical and biomedical careers: Creating a pipeline initiative.  Teach. Learn. Med. 2020; 1-12. DOI: 10.1080/10401334.2020.1729161.

Pei-Hsun Wu*, Daniele M. Gilkes, Jude M. Phillip, Akshay Narkar, Thomas Wen-Tao Cheng, Jorge Marchand, Meng-Horng Lee, Rong Li, Denis Wirtz*. 2020. Single-cell morphology encodes metastatic potential. Sci. Adv. 6, eaaw6938 (2020) DOI: 10.1126/sciadv.aaw6938

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Duan X, Li Y, Yi K, Guo F, Wang H, Wu PH, Yang J, Mair DB, Morales EA, Kalab P, Wirtz D, Sun SX, Li R. Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes. Nat Commun. 2020 Jan 14;11(1):277. doi: 10.1038/s41467-019-14068-3.

Ruan L, Wang Y, Zhang X, Tomaszewski A, McNamara JT, Li R. 2020. Mitochondria-associated proteostasis. Ann Rev Biophys. 2020 Jan 13. doi: 10.1146/annurev-biophys-121219-081604. [Epub ahead of print].


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Pal DS*, Li X*, Banerjee T, Miao Y, Devreotes PN. 2019. The Excitable Signal Transduction Networks: Movers and Shapers of Eukaryotic Cell Migration. Int. J. Dev. Biol. 63(8-9-10):407-416. doi: 10.1387/ijdb.190265pd. *Equal contribution.

Li X, Miao Y, Pal DS, Devreotes PN. Excitable networks controlling cell migration during development and disease. Semin Cell Dev Biol. 2019 Dec 10;. doi: 10.1016/j.semcdb.2019.11.001. [Epub ahead of print] Review. PubMed PMID: 31836289; NIHMSID:NIHMS1546309

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Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN. How the mechanobiome drives cell behavior, viewed through the lens of control theory. J. Cell Sci. 2019; 132:1-10. jcs234476.

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Padmanaban V, Suhail Y, Bader JS, Ewald AJ, “E-cadherin suppresses invasion and promotes metastasis in multiple breast cancer models,” Accepted in Principle at Nature, 2019.

Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer and David F. Kashatus. Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth. Cell Reports. In press

Yamada T, Dawson TM, Yanagawa T, Iijima M, Sesaki H. SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy. Autophagy. 2019; In press.

Michael P. Catanzaro, Ashley Weiner, Amanda Kaminaris, Fei Cai, Cairong Li, Fengyi Zhao, Satoru Kobayashi, Tamayo Kobayashi, Yuan Huang, Hiromi Sesaki, Qiangrong Liang. Doxorubicin-induced Cardiomyocyte Death is Mediated by Unchecked Mitochondrial Fission and Mitophagy. FASEB J. In press.

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Surcel A, Robinson DN.* Meddling with myosin’s mechanobiology in cancer. Proc. Natl. Acad. Sci. U.S.A. 2019; 116(31): 15322-15323.

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Paul P, Ramachandran S, Xia S, Unruh JR, Conkright-Fincham J, Li R. 2019. Dopamine receptor antagonists as potential therapeutic agents for ADPKD. PLoS One. 2019 May 6;14(5):e0216220. doi: 10.1371/journal.pone.0216220. eCollection 2019

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Hickey JW, Dong Y, Chung JW, Salathe SF, Pruitt HC, Li X, Chang C, Fraser AK, Bessell CA, Ewald AJ, Gerecht S, Mao HQ, Schneck JP, ” Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy,” Adv Mater. 2019 Apr 10:e1807359. 

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Palma E, Ma X, Riva A, Iansante V, Dhawan A, Wang S, Ni HM, Sesaki H, Williams R, Ding WX, Chokshi S. Dynamin-1-Like Protein Inhibition Drives Megamitochondria Formation as an Adaptive Response in Alcohol-Induced Hepatotoxicity. Am J Pathol. 2019 Mar;189(3):580-589.

Schiffhauer ES, Ren Y, Iglesias V, Kothari P, Iglesias PA, Robinson DN*. Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics. J. Cell Biol. 2019; 218(3): 895-908. (Includes 4 pages of Supplemental Figures)

Gutiérrez MS, Campusano S, González AM, Gómez M, Barahona S, Sepúlveda D, Espenshade PJ, Fernández-Lobato M, Baeza M, Cifuentes V, Alcaíno J. Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in Xanthophyllomyces dendrorhous. Front Microbiol. 2019 Mar 29;10:586. doi: 10.3389/fmicb.2019.00586. eCollection 2019.

Miao Y, Battacharya S, Banerjee T, Abudaker-Sharif B, Long Y, Inoue T, Iglesias P and Devreotes P. (2019). Wave patterns organize cellular protrusions and control cortical dynamics. Molecular Systems Biology 15(3). DOI 10.15252/msb.20188585| Published online 11.03.2019.

Kothari P, Srivastava V, Aggarwal V, Tchernyshyov I, Van Eyk J, Ha T, and Robinson DN*. Contractility kits promote assembly of the mechanoresponsive cytoskeletal network. J. Cell Sci. 2019; 132(2): 1-12. (Cover article; includes 11 pages of Supplemental Figures and Tables; first author was featured in a “First Person – Priyanka Kothari” interview, J. Cell Sci 2019 132: jcs229195)

Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G. (2019).  Probing the function of metazoan histones with a systematic library of H3 and H4 mutants.  Dev Cell Feb 11;48(3):406-419.

Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, Cameron AM, Wolfgang CL, Pawlik TM, Ghiaur G, Ewald AJ, Mezey E, Bader JS, Selaru FM, “Human primary liver cancer organoids reveal intra-tumor and inter-patient drug response heterogeneity,” JCI Insight. 2019 Jan 24;4(2). pii: 121490.

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Kojima R, Kakimoto Y, Furuta S, Itoh K, Sesaki H, Endo T, Tamura Y. Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport. Cell Rep. 2019 Jan 15;26(3):518-528.


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Mair, Devin B., Heather M. Ames, and Rong Li. “Mechanisms of invasion and motility of high-grade gliomas in the brain.” Molecular biology of the cell 29.21 (2018): 2509-2515

Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, and Ueda M. (2018). Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis. Biochemical and Biophysical Research Communications. Nov 16. pii: S0006-291X(18)32435-5. doi: 10.1016/j.bbrc.2018.11.029. [Epub ahead of print] PubMed PMID: 30454895.

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Adachi Y, Iijima M, Sesaki H. An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid. Small GTPases. 2018 Nov 2;9(6):472-479. doi: 10.1080/21541248.2017.1321614. Epub 2017 Jun 23.

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Liu X, Cheng Y, Wang Z, Abraham J, Wang Z, Ke X, Yan R, Zhang G, Khashab M, Shin EJ, McNamara G, Ewald AJ, Lin DC, Liu Z, Meltzer S, “Modeling Wnt signaling in Barrett’s neoplasia using human Barrett’s epithelial organoids and CRISPR-Cas9 genome editing,” Cancer Lett. 2018 Nov 1;436:109-118.

Simon DN, Wriston A, Florwick A, Fan Q, Dharmaraj T, Shabanowitz J, Peterson SB, Gruenbaum Y, Carlson CR, Gronning-Wang LM, Hunt DF and Wilson KL (2018) OGT (O-GlcNAc transferase) selectively modifies multiple residues unique to lamin A. Cells 7:44

Greenspan, L.J., and Matunis, E.L. (2018).  Retinoblastoma intrinsically regulates niche cell quiescence, identity, and niche number in the adult Drosophila testis. Cell Reports 25;24(13):3466-3476.

Liu Y and Robinson D*. Recent advances in cytokinesis: Understanding the molecular underpinnings. F1000Research 2018; 7(F1000 Faculty Rev): 1849.

Kriebel PW, Majumdar R, Jenkins LM, Senoo H, Wang W, Ammu S, Chen S, Narayan K, Iijima M, Parent CA. Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals. J Cell Biol. 2018;217(8):2891-2910.

Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Kato T, Araki Y, Huganir RL, Dawson TM, Yanagawa T, Okamoto K, Iijima M and Sesaki H. (2018). Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease. Cell Metab. 2018 Oct 2;28(4):588-604.e5.

Sirka OK, Shamir ER, Ewald AJ, “Myoepithelial cells are a dynamic barrier to epithelial dissemination,” Journal of Cell Biology, 2018 Oct 1;217(10):3368-3381.

Kim DH, Ewald AJ, Park JS, Kshitiz, Kwak M, Gray RS, Su CY, Seo J, An SS, Levchenko A, “Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread”, Sci Rep. 2018 Sep 21;8(1):14210. 

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Li X, Edwards M, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, and Devreotes PN. 2018. Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration. PNAS published ahead of print Sept. 7, 2018.

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Hennings TG, Chopra DG, DeLeon ER, VanDeusen HR, Sesaki H, Merrins MJ, Ku GM. In Vivo Deletion of Beta-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption. Endocrinology. 2018 Sep 1;159(9):3245-3256. 

Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H. A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane. J Biol Chem. 2018 Jul 27;293(30):11809-11822.

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Cuei-Ling Wang, Yu-Chen Chang, Ya-Chu Chang, Shi-Rong Hong, Chun-Yu Lin, Ning Hsu, Hsiao-Chi Cheng, Yueh-Chen Chiang, Wei-En Huang, Nathan C. Shaner, Rajat Rohatgi, Inoue T, Yu-Chun Lin. (2018).“Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.”Nature Communications 2018:9:1732:1-13

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Gajendiran P, Vega LI, Itoh K, Sesaki H, Vakili MR, Lavasanifar A, Hong K, Mezey E, Ganapathy-Kanniappan S. 2018. Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin. J Cell Mol Med. 2018 Apr;22(4):2210-2219. doi: 10.1111/jcmm.13501. Epub 2018 Feb 4.

Ewald AJ. 2018. Metastasis inside-out: dissemination of cancer cell clusters with inverted polarity. EMBO J. 2018 Apr 3;37(7). pii: e99144. doi: 10.15252/embj.201899144. Epub 2018 Mar 9. No abstract available. PMID:29523585

Sisk, J.M., M.B. Frieman and C.E. Machamer. 2018. Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors. J. Gen. Virol., Mar 20. doi: 10.1099/jgv.0.001047. [Epub ahead of print]

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Neumann NM, Perrone MC, Veldhuis JH, Huebner RJ, Zhan H, Devreotes PN, Brodland GW, and Ewald AJ. 2018. Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drives radial intercalation and tube elongation. Dev Cell Apr 9;45(1):67-82.e6. doi: 10.1016/j.devcel.2018.03.11.

Chou FS, Li R, Wang PS. Molecular components and polarity of radial glial cells during cerebral cortex development. 2018. Cell Mol Life Sci. 2018 Mar;7 5(6):1027-1041. doi: 10.1007/s00018-017-2680-0.

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Jin Zhu, Hung-Ji Tsai, Molly R. Gordon, Rong Li. Cellular Stress Associated with Aneuploidy; Dev Cell. 2018 Feb 26;44(4):420-431. doi: 10.1016/j.devcel.2018.02.002.

Linhao Ruan, Xi Zhang, Rong Li. Recent insights into the cellular and molecular determinants of aging. J Cell Sci. 2018 Feb 2; 131(3). pii: jcs210831. doi: 10.1242/jcs.210831

Perry HM, Huang L, Wilson RJ, Bajwa A, Sesaki H, Yan Z, Rosin DL, Kashatus DF, Okusa MD. 2018. Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI. J Am Soc Nephrol. 2018 Jan;29(1):194-206


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Pushpendra Singh, Rong Li. Emerging roles for sphingolipids in cellular aging. Curr Genet. 2017 Dec 19. doi: 10.1007/s00294-017-0799-z. 

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Miao C, Schiffhauer ES, Okeke E, Robinson DN, Luo T. 2017. Parallel compression is a fast, low-cost assay for the high throughput screening of mechanosensory cytoskeletal proteins in cells. ACS Appl. Mater. Interfaces 2017; 9(34): 28168-28179. ACS Appl. Mater. Interfaces 2017; 9(34): 28168-28179

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Surcel A, Schiffhauer ES, Thomas D, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee E, Iglesias P, Anders R, Robinson DN. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv 190553; doi: 2017

Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. Entosis is induced by glucose starvation. Cell Reports. 20(1): 201-210. 2017

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McDonald NALind ALSmith SELi RGould KL. Nanoscale architecture of the Schizosaccharomyces pombecontractile ring. Elife. 2017 Sep 15; 6. pii: e28865. doi: 10.7554/eLife.28865.

Yochum ZA, Cades J, Mazzacurati L, Neumann NM, Khetarpal SK, Chatterjee S, Wang H, Attar MA, Huang EH, Chatley SN, Nugent K, Somasundaram A, Engh JA, Ewald AJ, Cho YJ, Rudin CM, Tran PT, Burns TF. 2017. A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer. Mol Cancer Res. 2017 Dec;15(12):1764-1776. doi: 10.1158/1541-7786.MCR-17-0298. Epub 2017 Aug 29.

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Nguyen-Ngoc KV, Silvestri VL, Georgess D, Fairchild AN, Ewald AJ. 2017. Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation. J Cell Sci. 2017 Oct 1;130(19):3213-3221. doi: 10.1242/jcs.208546. Epub 2017 Aug 18.

Perurena N., Zandueta C., Martínez-Canarias S., Moreno H., Vicent S., Almeida A.S., Guruceaga E., Gomis R.R., Santisteban M., Egeblad M., Hermida J., and Lecanda F. (2017) EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth. J Hematol Oncol;10(1):23. doi: 10.1186/s13045-017-0399-x.

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Albrengues, J., Wysocki, R.W., Maiorino, L., Egeblad M. (2017) Preview: Re-cyclin’ cell-cycle components to make NETs. Dev Cell, 43, 379-80.

Greenspan LJ, Matunis EL. 2017. Live Imaging of the Drosophila Testis Stem Cell Niche. Methods Mol Biol. 1463:63-74.

Burr R, Stewart EV, Espenshade PJ. 2017. Coordinate regulation of yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 transcription factors. J. Biol. Chem. 292:5311-5324. PMCID: PMC5392677

Adachi Y, Itoh K, Iijima M, Sesaki H. 2017. Assay to measure interactions between purified Drp1 and synthetic liposomes. Bio-Protocol. Vol 7, Iss 9.

Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. 2017. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab. 25(3):647-660.

Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM. 2017. The putative Drp1 inhibitor mdivi-1 Is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species. Dev Cell. 2017;40(6):583-594.

Florwick A, Dharmaraj T, Jurgens J, Valle D, Wilson KL. 2017.  LMNA sequences of 60,706 unrelated individuals reveal 132 novel missense variants in A-type lamins and suggest a link between variant p.G602S and Type 2 Diabetes.  Jun 15;8:79. doi: 10.3389/fgene.2017.00079. eCollection 2017.

Pereira R, Tadinada SM, Zasadny FM, Oliveira K, Pires KM, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. 2017. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.  2017 Jun 12. pii: e201696179. doi: 10.15252/embj.201696179. [Epub ahead of print]

Cho B, Cho HM, Jo MY, Kim HD, Song M, Moon C, Kim H, Kim K, Sesaki H, Rhyu IJ, Kim H. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division.  2017 Jun 9;8:15754. doi: 10.1038/ncomms15754.

Watanabe S. and Boucrot E. (2017) Fast and ultrafast endocytosis. Curr Opin Cell Biol. 5;47:64-71.

Topalidou I, Chen PA, Cooper K, Watanabe S, Jorgensen EM, Ailion M. (2017). The NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans. Genetics May;206(1):265-282.

Schiffhauer E, Robinson DN. 2017. Mechanochemical signaling directs cell shape change. Biophys. J. 112: 207-214. (Featured article)

Kothari P, Schiffhauer E, Robinson DN. Cytokinesis from nanometers to micrometers and microseconds to minutes. 2017. Methods Cell Biol. 137:307-322.

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T “Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.” Cell 2017;168:264-279

Yamada T, Adachi Y, Yanagawa T, Iijima M, Sesaki H. 2017. p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. Neurochem Int. 2017 May 18. pii: S0197-0186(17)30189-4. doi: 10.1016/j.neuint.2017.05.012.

Rohani A, Moore JH, Kashatus JA, Sesaki H, Kashatus DF, Swami NS. Label-Free Quantification of Intracellular Mitochondrial Dynamics Using Dielectrophoresis. Anal Chem. 2017 Jun 6;89(11):5757-5764. doi: 10.1021/acs.analchem.6b04666. Epub 2017 May 15

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel M, Gabelli SB, Cole PA.  2017. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell 66 (3): 345-357. PMID: 28475870. DOI: 10.1016/j.molcel.2017.03.020

Xian L, Georgess D, Huso T, Cope L, Belton A, Chang YT, Kuang W, Zhang X, Senger S, Fassano A, Huso DL, Ewald AJ, Resar LMS. 2017. HMGA1 Amplifies Wnt Signaling and Expands the Intestinal Stem Cell Compartment and Paneth Cell Niche. Nat Communications, 2017 Apr 28;8:15008

Wells MB, Villamor J, and Andrew DJ. Salivary gland maturation and duct formation in the African malaria mosquito Anopheles gambiae. 2017. Scientific Reports 7:601. DOI: 10.1038/s41598-017-00672-0.

Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. 2017. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 121(3):220-233.

Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias P, Devreotes PN. 2017.  Altering the threshold of an excitable signal transduction network changes cell migratory modes.  Nat Cell Biol 19:329-340.

Ruan L, Zhou C, Jin E, Kucharavy A, Zhang Y, Wen Z, Florens L, Li R. 2017. Cytosolic proteostasis through importing of misfolded proteins into mitochondriaNature; Mar 16; 543, 443–446; doi:10.1038/nature21695

Chung S, Kim S, and Andrew DJ. 2017. Uncoupling apical constriction from tissue invagination. Elife Mar6;6. pii: e22235. doi: 10.7554/eLife.22235. PMCID: PMC5338918

Yang J-M,  Schiapparelli P,  Nguyen H-N, Igarashi A, Zhang Q, Abbadi S, Amzel LM, Sesaki H, Quinones-Hinojosa A and Iijima M. 2017. Characterization of PTEN mutations in brain cancer reveals that PTEN mono-ubiquitination promotes protein stability and nuclear localization. Oncogene. Jun 29;36(26):3673-3685. doi: 10.1038/onc.2016.493. Epub 2017 Mar 6.

Ewald AJ. 2017. Pulling cells out of tumors. Nat Cell Biol. 2017 Mar 1;19(3):147-149. 

Nakamura H, Inoue T. 2017. Japanese Scientists in Science Signaling 2016. Science Signaling 2017 (In press)

Yang X, Wang H, Ni HM, Xiong A, Wang Z, Sesaki H, Ding WX, Yang L. 2017. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol. 12:264-273

Salka K, Bhuvanendran S, Wilson K, Bozidis P, Mehta M, Rainey K, Sesaki H, Patterson GH, Jaiswal JK, Colberg-Poley AM. 2017. Superresolution imaging identifies that conventional trafficking pathways are not essential for endoplasmic reticulum to outer mitochondrial membrane protein Transport. Sci Rep. 7 (1):16.

Kwon D, Park E, Sesaki H, Kang SJ. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. 2017. Biochem Biophys Res Commun. 493(1):737-743

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. 2017. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell 2017;168:264-279

Niu J., Johny M.B., Dick I.E., Inoue T. 2016. Following Optogenetic Dimerizers and Quantitative Prospects. Biophysical Journal 111:1132–1140


Gaus K., Inoue T. 2016. New Biological Frontiers Illuminated by Molecular Sensors and Actuators. Biophysical journal. 2016; 111(6):E01-2.

Dorn J, Zhang L, Maddox P, Liu J, Maddox A. 2016. A theoretical model of cytokinesis implicates feedback between membrane curvature and cytoskeletal organization in asymmetric cytokinetic furrowing. Molecular Biology of the Cell 27(8): 1286-99

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. 2016. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 35:2332-2349. PMCID: PMC5090219

Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. 2016. Dynamin-Related Protein 1 Deficiency Leads to Receptor-Interacting Protein Kinase 3-Mediated Necroptotic Neurodegeneration. 2016. Am J Pathol. Nov;186(11):2798-2802.

Ibo M, Srivastava V, Robinson DN, Gagnon Z. Cell blebbing in confined microfluidic environments. PLoS One 2016; 11(10): e0163866.

Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, James CD, Molinaro AM, Shieh JT, Phillips JJ. 2016. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016 Nov 29; 7(48):79101-79116

Artemenko Y, Axiotakis L Jr., Borleis J, Iglesias PA, Deveotes PN. 2016. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proc Natl Acad Sci USA. Nov. 22; 113(47):E7500-E7509. PMCID: PMC5127353

Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH. 2016. Protective Effects of Reduced Dynamin-related Protein 1 Against Amyloid Beta-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease. Hum Mol Genet. 25(23):5148-5166.

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Teo WW, Merino V, Cho S, Korangath P, Liang X, Wu R, Neumann NM, Ewald AJ, Sukumar S. 2016.  HOXA5, a regulator of cell fate transition, impedes tumor initiation and progression in breast cancer. Oncogene. 2016 Oct 20; 35(42):5539-5551. 

Kojima R, Kajiura S, Sesaki H, Endo T, Tamura Y. 2016. Identification of multi-copy suppressors for ER-mitochondria tethering proteins in Saccharomyces cerevisiae. FEBS Lett. 2016; Epub ahead of print.

Adachi Y, Itoh K, Yamada T, Cerveny KL, Suzuki TL, Macdonald P, Frohman MA, Ramachandran R, Iijima M, Sesaki H. Coincident phosphatidic acid interaction restrains Drp1 in mitochondrial division. Mol Cell. 2016;63:1034-43.

Shamir ER, Coutinho K, Auer M, Ewald AJ. 2016. Twist1+ epithelial cells retain adhesive and proliferative capacity during dissemination. Biol Open. 2016 Sep 15; 5 (9):1216-1228. 

Hanlon CD, Andrew DJ. Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. 2016. Dev Biol. 2016 Nov 15;419(2):273-284. doi: 10.1016/j.ydbio.2016.09.007. Epub 2016 Sep 13.

Potapova TA, Seidel CW, Box AC, Rancati G, Li R. 2016. Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. Mol Biol Cell. 2016 Oct 15;27(20):3065-3084. Epub 2016 Aug 24.

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Loganathan R, Lee JS, Wells MB, Grevengood E, Slattery M, Andrew DJ. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol. 2016 Jan 1;409(1):234-50

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Zhang L, Trushin S, Christensen TA, Bachmeier BV, Gateno B, Schroeder A, Yao J, Itoh K, Sesaki H, Poon WW, Gylys KH, Patterson ER, Parisi JE, Diaz Brinton R, Salisbury JL, Trushina E. Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease. Sci Rep. 2016;6:18725

Senoo H, Cai H, Wang Y, Sesaki H, Iijima M. The novel racE binding protein GflB sharpens ras activity at the leading edge of migrating cells. Mol Biol Cell. 2016;27(10):1596-605.

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Cheung KJ, Padmanaban VP, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Ewald AJ, “Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters,” 2016, Feb 1, PNAS.

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Gao R, Zhao S, Sun Y, Sanjun Zhao, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, Pan T, Devreotes PN, Zhao M.  2015.  A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium Discoideum.  Sci Signal, May 26;8(378):ra50. Doi: 10.1126/scisignal.aab0562.  PMID: 26012633

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Kim JH, Ren Y, Ng WP, Li S, Son S, Kee Y-S, Zhang S, Zhang G, Fletcher DA, Robinson DN, Chen EH. Mechanical tension drives cell membrane fusion. Dev. Cell 2015; 561-573. 

Srivastava V, Robinson DN. Mechanical stress and network structure drive protein dynamics during cytokinesis. Curr. Biol. 2015; 25(5): 663-670. 

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Luo T, Robinson DN. Kinetic Monte Carlo simulations of the assembly of filamentous biomacromolecules by the dimer addition mechanism. RSC Adv. 2015; 5: 3922-3929.


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Zhu J, Pavelka N, Bradford WD, Rancati G, Li R. Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast. PLoS Genet. 2012;8:e1002719.

Kageyama, Y., Zhang, Z., Roda, R., Fukaya, M., Wakabayashi, J., Wakabayashi, N., Kensler, T.W., Reddy, P.H., Iijima, M. and Sesaki, H. (2012). Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J. Cell Biol. 197(4):535-51.

Engelhardt, J.J., Boldajipour, B., Beemiller, P., Pandurangi, P., Sorenson, C., Werb, Z., Egeblad, M., and Krummel, M.F. (2012). Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell, 21, 402-417.

Nakasone, E.S., Askautrud, H.A., Kees , T., Parks, J.-H., Plaks, V., Ewald, A.J., Fein, M., Rasch, M.G., Tan, Y.X., Qiu, J., Park, J., Sinha, P., Bissell, M., Frengen, E., Werb, Z., and Egeblad, M. (2012) Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell, 21, 488-503. Selected for the cover. See also Research Highlights, Nature 2012, 485, 282.

Zhang, Z., Kageyama, Y., and Sesaki, H. (2012). Mitochondrial division prevents neurodegeneration. Autophagy. 8: 1531-1533

Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M, "Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium", J Cell Sci. 2012 Jun 1;125(Pt 11):2638-54. PMC3403234.

Tamura, Y., Onguka, O., Itoh, K., Endo, T., Iijima, M., Claypool, S.M., and Sesaki, H. (2012). Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins, Ups1p and Ups2p.  J. Biol. Chem. 287:43961-43971

Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sanséau, D., Willard, S.S., Schleicher, M., and Devreotes, P.N.  2012. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion.  PNAS 2012;109(34):13632-13637.

Tamura, Y., Onguka, O., Aiken Hobbs, A.E., Jensen, R.E., Iijima, M., Claypool, S.M., and Sesaki, H. (2012). Role for two conserved intermembrane space proteins, Ups1p and Up2p, in intra-mitochondrial phospholipid trafficking. J. Biol. Chem. 287(19):15205-15218.

Robinson DN, Iglesias PA. Bringing the physical sciences into your cell biology research. Mol. Biol. Cell 2012; 23(21): 4167-4170.

Michaelis, S. and Barrowman, J. Biogenesis of the Saccharomyces cerevisiae pheromome a-factor; from yeast mating to human disease. (2012) Microbiology and Molecular Biology Reviews 76: 626-651.

Chandran, S. and C.E. Machamer. 2012. Inactivation of ceramide transfer protein during proapoptotic stress by Golgi disassembly and caspase cleavage. Biochem. J., 442:391-402.

Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M, "Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance", Cancer Cell. 2012 Apr 17;21(4):488-503. Selected for Cover.

Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN. A mechanosensory system governs myosin II accumulation in dividing cells. Mol. Biol. Cell 2012; 23(8): 1510-1523.

Galloway, J.F., Winter, A., Lee, K.H., Park, J., Dvoracek, C., Devreotes, P.N., and Searson, P.C.  2012 Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications.  Nanomedicine 8:1190-1199.

Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012; 8(4): e1002467. 

Barrowman J., Wiley, P.A., Hudon, S., Hrycyna, C.A. Michaelis, S. (2012) Human ZMPSTE24 disease mutations: residual enzymatic activity correlates with disease severity. Human Molecular Genetics 21:4084-4093.

Ruch, T.R. and C. E. Machamer. 2012. The coronavirus E protein: assembly and beyond.  Viruses 4:363-382. 

Chen, C-L., Wang, Y., Sesaki, H., and Iijima, M. Myosin I links PIP3 signaling to remodeling of the actin cytoskeleton in chemotaxis. Science Signaling. (2012). 5: ra10

Gjerstorff MF, Rösner HI, Pedersen CB, Greve KB, Schmidt S, Wilson KL, Mollenhauer J, Besir H, Poulsen FM, Møllegaard NE and Ditzel HJ. (2012) GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). PloS One 7:e45819.

Barkan R, Zahand AJ, Sarabi K, Lamm AT, Feinstein N, Haithcock E, Wilson KL, Liu J and Gruenbaum Y. (2012) Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function and mitosis. Molecular Biology of the Cell 23:543-552. 

Manczak, M., Sesaki, H., Kageyama, Y., and Reddy, P.H. (2012). Dynamin-related protein 1heterozygote knockout mice do not have synaptic and mitochondrial deficiencies. Biochim Biophys Acta. 1822(6):862-74.

Dickinson D, Robinson DN, Nelson WJ, Weis WI. α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev. Cell 2012; 23: 533-546.

Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN. Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J. 2012; 102(2): 238-247. 

Barrowman, J., Hamblet, C., Kane M.S., Michaelis, S. (2012) Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24. PLoS ONE 7: e32120.

Iglesias, P.A. and Devreotes, P.N.  2012 Biased excitable networks: how cells direct motion in response to gradients. Curr. Opin. Cell Biol., 757:451-468.

Ruch, T.R. and C.E. Machamer. 2012. A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. PLoS Pathogens 8(5):e1002674.

Chen, C-L. and Iijima, M. Myosin I: a new PIP3 effector in chemotaxis and phagocytosis. Commun. Integr. Biol. (2012). 5: 294-296

Miyamoto T., DeRose R., Suarez A., Ueno T., Chen M., Sun T.-p., Wolfgang M.J., Mukherjee C., Meyers D. and Inoue T. “Generation of Intracellular Logic Gates with Two Orthogonal Chemically Inducible Systems” Nature Chemical Biology (Accepted 2012)

Porter JR, Lee CSY, Espenshade PJ, Iglesias PA. 2012. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol. Biol. Cell 23:3764-3774.

Shao W, Espenshade PJ. 2012. Expanding roles for SREBP in metabolism. Cell Met. 16:414-419.

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman, JI, Jiang L, Kuo D, Tosti E, Kim H, Edelmann W, Keogh M, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. 2012. Hierarchical modularity and the evolution of genetic interactomes across species. Mol. Cell. 46:691-704.

Yamanaka, S., Campbell, N.R., An, F., Kuo, S.C., Potter, J.J., Mezey, E., Maitra, A., and Selaru, F. (2012) Coordinated effects of microRNA-494 induce G2/M arrest in human cholangiocarcinoma. Cell Cycle 11, 2729-38

Cai, H., Huang, C.H., Devreotes, P.N., and Iijima, M.  2012  Analysis of chemotaxis in Dictyostelium.  Methods Mol Biol 757:451-468.

Trushina, E., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T.M., Poduslo, J., and Dzeja, P. (2012). Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS ONE. 7(2): e32737.


Estela, A., Pla-Martin. D., Sanchez-Piris. M., Sesaki. H., and Palau F. (2011). The Charcot-Marie-Tooth related gene GDAP1 complements cell cycle delay at G2/M in S. cerevisiae fis1 defective cells. J. Biol. Chem. 286: 36777-36786

Rivera Rosado, L.A., Horn, T.A., McGrath, S.C., Cotter, R.J. and Yang, J.T. (2011). Association between a4 integrin cytoplasmic tail and non-muscle myosin IIA regulates cell migration.  J. Cell Sci. 124, 483-492.

Zhou C, Slaughter BD, Unruh JR, Eldakak A, Rubinstein B, Li R. Motility and segregation of hsp104-associated protein aggregates in budding yeast. Cell. 2011;147:1186-1196. 

Yi K, Unruh JR, Deng M, Slaughter BD, Rubinstein B, Li R. Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes. Nat Cell Biol. 2011;13:1252-1258.

Issigonis M, Matunis E.  2011.  SnapShot: stem cell niches of the Drosophila testis and ovary.  Cell. 145: 994-994.e2.  PMID: 21663800.

Hobson, R.J., Q. Liu, S. Watanabe and E.M. Jorgensen. 2011. Complexin maintains vesicles in the primed state in C. elegans. Current Biology 21, p106-113. PMCID: PMC348763.

Gao JT, Guimera R, Li H, Pinto IM, Sales-Pardo M, Wai SC, Rubinstein B, Li R. Modular coherence of protein dynamics in yeast cell polarity system. Proc Natl Acad Sci U S A. 2011;108:7647-7652. 

Watanabe, S., A. Punge , G. Hollopeter , K.I. Willig, R.J. Hobson  , M.W. Davis , S.W. Hell , and E.M. Jorgensen. 2011. Protein localization in electron micrographs using fluorescence nanoscopy.  Nature Methods 8, p80-84. PMCID: PMC3059187.

Oikonomou, G., Perens, E. A., Lu, Y., Watanabe, S., Jorgensen, E. M., and Shaham, S. (2011). Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans. PLoS Biol. 9, e1001121. PMCID: PMC3153439.

Tang, M., Iijima, M., and Devreotes, P. Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle. (2011). 10: 2817-2818


Kees, T. and Egeblad, M. (2011). Innate immune cells in breast cancer – from villains to heroes? J Mammary Gland Biol Neoplasia, 16, 189-203.

Tang, M., Iijima, M., Kamimura, Y., Chen, L., Long, Y., and Devreotes, P. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol. Biol. Cell. (2011). 22: 437-47.

Maruyama, R., Grevengoed, E., Stempniewicz, P., Andrew, D.J. (2011) Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene fork headPLoS One 6(6): e20901. PMID: 21698206

Cai, H., and Devreotes, P.N. 2011 Moving in the right direction: How eukaryotic cells migrate along chemical gradients. Semin. Cell Dev. Biol. 22:834-841.

Ruch, T.R. and C.E. Machamer.  2011. The hydrophobic domain of the infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus.  J. Virol. 85:675-685.

Gao, R.C., Zhang, X.D., Sun, Y.H., Kamimura,Y., Mogilner, A., Devreotes, P.N., and Zhao, M.  2011.  Different roles of Membrane potentials in electrotaxis and chemotaxis of Dictyostelium Cells.  Eukaryot Cell, 10:1251-1256.

Zuckerman, D.M. S.W. Hicks, G. Charron, H.C. Hang, and C.E. Machamer.  2011.  Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta-1 adrendergic receptor. J. Biol. Chem. 286:19014-23.

Tamura, Y., Itoh, K. and Sesaki, H. (2011). SnapShot: Mitochondrial dynamics. Cell. 145:1158-11581e

Artemenko, Y., Swaney, K., and Devreotes, P.N.  2011.  Assessment of development and chemotaxis in Dictyostelium discoideum mutants.  Meth. Mol. Biol. 769:287-309.

Sheng, X. R., Matunis, E. L.  2011.  Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output.  Development 16:3367-3376.

Wang, Y., Steimle, P.A., Ren, Y., Ross, C.A., Robinson, D.N., Egelhoff, T.T., Sesaki, H., and Iijima, M. Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation. Mol. Biol. Cell. (2011). 22: 2270-2281

Kageyama, Y., Zhang, Z., and Sesaki, H. (2011). Mitochondrial division: molecular machinery and physiological functions. Curr. Opin. Cell Biol. 23: 427-34.

de Keijzer, S., Galloway, J., Devreotes, P.N., and Iglesias, P.A.  2011 Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane.  Biochimica et Biophysica Acta, 1808:1701-1708.

de Cuevas, M., Matunis, E. L.  2011.  The stem cell niche: Lessons from the Drosophila testis.  Development 14:2861-2969.  

Cohen, J.R., L.D. Lin and C.E. Machamer. 2011.  Identification of a Golgi targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein.  J. Virol. 85:5794-5803.

Wang, Y., Chen, C-L., and Iijima, M. Signaling mechanisms for chemotaxis. Development Growth and Differentiation (2011). 53: 495-502

Simon DN and Wilson KL. (2011) The nucleoskeleton as a dynamic genome-associated ‘network of networks.’ Nature Reviews Mol. Cell. Biol. 12:695-708.

Wilson KL and Dawson SC. (2011) Functional evolution of nuclear structure. J Cell Biology 195:171-181.

Montes de Oca RM, Andreassen PR and Wilson KL. (2011) Barrier to Autointegration Factor influences specific histone modifications. Nucleus 2:580-590. 

Ueno T., Falkenburger B.H., Pohlmeyer C., and Inoue T. “Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization” ScienceSignaling 4(203), ra87 (2011) (Cover Article)

Umeda N., Ueno T., Pohlmeyer C., Nagano T. and Inoue T. “A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity” Journal of American Chemical Society 133(1), 12-14 (2011) Note: “Scientist use light to move molecules within living cells” Science News article in ScienceDaily

Ewald AJ*, “Imaging the Cell Behavioral Basis of Branching Morphogenesis in 3D Organotypic and Whole Organ Cultures”, Imaging in Developmental Biology, A Laboratory Manual, 2nd Edition, Edited by James Sharpe and Rachel Wong, Cold Spring Harbor Laboratory Press, 2011. 

Stewart EV, Lloyd SJ, Burg JS, Nwosu CC, Lintner RE, Daza R, Russ C, Ponchner K, Nusbaum C, Espenshade PJ. 2011. Yeast SREBP cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J. Biol. Chem. 287:672-81.

Lee CSY, Yeh TL, Hughes BT, Espenshade PJ. 2011. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol. Cell 44:225-234.

Burg JS, Espenshade PJ. 2011. Glucose controls phosphoregulation of HMG-COA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast. J. Biol. Chem. 286:27139-46.

Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. 2011. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol. Cell 42:160-171.

Chung, S.-Y., Chavez, C. and Andrew, D.J. (2011) Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Developmental Biology 360: 160-172. PMID: 21963537

Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W.-J., Sereda, S., Clerc, P., Polster, B.M., Aja, S.M., Pletnikov, M.V., Kensler, T.W., Shirihai, O.S.,., Iijima, M., Hussain, M., and Sesaki, H. (2011). The Dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol. Biol. Cell. 22: 2235-2245. 

Nakamura. K., Nemani, V.M., Azarbal, F., Skibinski, G., Levy, J.M., Egami, K., Munishkina,L., Zhang, J., Gardner, B., Wakabayashi, J., Sesaki, H., Cheng, Y., Finkbeiner, S., Nussbaum,.R.L., Masliah, E., and Edwards, R.H. (2011). Direct membrane association drives mitochondrial fission by the Parkinson Disease-associated protein α-synuclein. J. Biol. Chem. 286: 20710-20726.


Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137:1075-1084.

Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, Sanderson BW, Hattem GL, Li R. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature. 2010;468:321-325.

Ou, C.-Y., Poon, V. Y., Maeder, C. I., Watanabe, S., Lehrman, E. K., Fu, A. K. Y., Park, M., Fu, W.-Y., Jorgensen, E. M., Ip, N. Y., et al. (2010). Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell 141, 846–858. PMCID: PMC3168554.

Issigonis M, Matunis E.  2010.  Previews. Niche today, gone tomorrow–progenitors create short-lived niche for stem cell specification.  Cell Stem Cell 6: 191-3.  PMID: 20207220.

Pellettieri, J., Fitzgerald, P., Watanabe, S., Mancuso, J., Green, D. R., and Sánchez Alvarado, A. (2010). Cell death and tissue remodeling in planarian regeneration. Dev. Biol. 338, 76–85. PMCID: PMC2835816.

QnAs with Peter N. Devreotes. 2010 Interview by Prashant Nair. PNAS, 107:19613. PMCID: PMC2993395

Cai, H., Das, S., Kamimura, Y., Comer, F.I., Parent, D.A., and Devreotes, P.N.  2010  Ras-mediated activation and inactivation of the TorC2-PKB pathway are critical for chemotaxis.  J. Cell Biol., 190:233-245. PMCID: PMC2930282

Egeblad, M., Nakasone, E.S., and Werb, Z. (2010). The tumor as an organ: complex tissues that interface with the entire organism. Dev Cell, 18, 884-901.

Egeblad M., Rasch, M.G., and Weaver V.M. (2010). Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol, 22, 697-706.

Sounni, N.E., Dehne, K., van Kempen, L.C.L., Egeblad, M., Affara, N.I., Cuevas, I., Wisen J., Junankar, S., Korets, L., Lee, J., Shen, J., Morrison, C.J., Overall, C. M., Krane, S.M., Werb, Z., Boudreau, N., and Coussens, L.M. (2010). Stromal Regulation of Vessel Stability by MMP14 and TGFβ. Dis Model Mech, 3, 317-32.

Kamimura, Y., Cai, H., Tang, M., and Devreotes, P.N. 2010 TorC2 and chemotaxis in Dictyostelium discoideum. In: The Enzymes (Michael N. Hall and Fuyuhiko Tamanoi, eds.). Acadmic Press, Volume 28, pp. 125-142.

Andrew, DJ and Ewald, AJ, “Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration”, Developmental Biology, 2010 May 1;341(1):34-55.

Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P.N., Robinson, D.N., and Iglesias, P.A.  2010  Automated characterization of cell shape changes during amoeboid motility by skeletonization.  BMC Syst. Biol., 4:33. PMCID: PMC2864235

Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Tran ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN. 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889.

Chandran, S. and C.E. Machamer. 2010. Golgi organization and stress sensing.  The Golgi apparatus: Structure, Functions and Mechanisms.  (Nova Science, Inc, Hauppauge NY). 

Larson SM, Lee HJ, Hung P-h, Matthews LM, Robinson DN, Evans JP. Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and ezrin-radixin-moesin (ERM) proteins. Mol. Biol. Cell 2010; 21:3182-3192.

Cherry, C.M., Matunis, E.L. 2010.  Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome remodeling factor NURF.  Cell Stem Cell 6:557-567.

McBride, C.E. and C.E. Machamer.  2010. Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein.  Virology 405:139-148.

Simon DN, Zastrow MS, Wilson KL. (2010) Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. Nucleus 1:264-272. 

Wilson KL and Berk JM. (2010) The nuclear envelope at a glance. J Cell Science 123:1973-1978. 

Komatsu T., Kukelyansky I., McCaffery J.M., Ueno T., Varela L.C. and Inoue T. “Organelle-Specific, Rapid Induction of Molecular Activities and Membrane Tethering” Nature Methods 7, 206-208 (2010) Note: “Hopkins researchers put proteins right where they want them” Breaking News article in Genetic Engineering and Biotechnology News

Porter JR, Burg JS, Espenshade PJ, Iglesias PA. 2010. Ergosterol regulates SREBP cleavage in fission yeast. J. Biol. Chem. 285:41051-61.

Bien CM and Espenshade PJ. 2010. SREBP in fungi – Hypoxic transcription factors linked to pathogenesis. Eukaryotic Cell 9:352-9.

Fox, R.M., Hanlon, C.D. and Andrew, D.J. (2010) The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Journal of Cell Biology 191: 479-492. PMID: 21041443

Kerman, B.E. and Andrew, D.J. (2010) Staying alive: Dalmatian-mediated epigenetic blocking of apoptosis is essential for tissue maintenance. Developmental Dynamics 239:1609-21. PMID: 20503358

Swaney, K.F., Huang, C.H., Devreotes, P.N. 2010. Eukaryotic Chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 278:20445-20448.

Xiong, Y., Huang, C-H, Iglesias, P.A., and Devreotes, P.N. 2010. Cells navigate with a local-excitation, global-inhibition-biased excitable network. PNAS, 107:17079-17086.

Tamura, Y., Iijima, M., and Sesaki, H. Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. EMBO J. (2010). 29: 2875-2887.

Kamimura, Y., and Devreotes, P.N.  2010  Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis.  J Biol Chem 285(11):7938-7946. PMCID: PMC2832944

Kane LA, Youngman MJ, Jensen RE, Van Eyk JE. (2010). Phosphorylation of the F1-Fo ATP synthase beta subunit: functional and structural consequences assessed in a model system. Circ. Res. 106: 504-513.

Zhang, P., Wang, Y., Sesaki, H. and Iijima, M. Proteomic identification of PtdIns(3,4,5)P3-binding proteins in D. discoideum. Proc. Natl. Acad. Sci. USA. (2010). 107: 11829-11834.


Liu J, Sun YD, Drubin DG, Oster GF. 2009. The mechanochemistry of endocytosis. PLoS Biology 2009; 7(9): e1000204.

Liu J, Sun YD, Drubin DG, Oster GF. 2009. Themechanochemistry of endocytosis. PLoS Biology 7(9): e1000204.

Slaughter BD, Das A, Schwartz JW, Rubinstein B, Li R. Dual modes of cdc42 recycling fine-tune polarized morphogenesis. Dev Cell. 2009;17:823-835.

Sheng XR, Matunis EL.  2009.  Make room for dedifferentiation.  Fly 3: 283-5. PMID: 19923919.

Barnes, N., Bartee, M.Y., Braiterman, L., Gupta,A., Ustiyan, V., Zuzel, V., Kaplan, J.H., Hubbard, A.L., Lutsenko, S. 2009. Cell specific trafficking suggests a new role for renal ATPB in intracellular copper storage. Traffic 10:767-779.

Pramanik, Md K., Iijima, M., Iwadate, Y., and Yumura, S. PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells. Genes to Cells. (2009). 14: 821-34.

Levental, K.R., Yu, H., Kass, L., Lakins, J.N., Egeblad, M., Erler J.T., Fong, S.F., Csiszar, K.L., Giaccia, A., Weninger, W., Yamauchi, M., Gasser, D.L., and Weaver, V.M. (2009). Matrix cross-linking forces tumor progression by enhancing integrin signaling. Cell, 139, 891-906.

Metzger MB, and Michaelis S. (2009) Analysis of Quality Control Substrates in Distinct Cellular Compartments Reveals a Unique Role for Rpn4p in Tolerating Misfolded Membrane Proteins Mol. Biol. Cell 20:1006-1019.

Barrowman, J., and Michaelis, S. (2009) ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders. Biological Chemistry 390: 761-773.

Issigonis, M., Tulina, N., de Cuevas, M., Brawley, C., Sandler, L., Matunis, E. 2009.  JAK-STAT signal inhibition regulates competition within the Drosophila testis stem cell niche.  Science 326:153-6.

Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T.W., Iijima, M., and Sesaki, H. (2009). The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J. Cell Biol. 186: 805-816

Sheng, X.R., Brawley, C.M., Matunis, E.L. 2009.  Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis.  Cell Stem Cell 5:191-203.

Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock, RS, Robinson DN. Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr. Biol. 2009; 19(17):1421-1428.

Franca-Koh, J., Willard, S.S., and Devreotes, P.N. 2009 G-Protein Signaling in Chemotaxis. In: Ralph A. Bradshaw and Edward A. Dennis, editors, Handbook of Cell Signaling 2nd edition. Oxford: Academic Press, pp. 1705-1712.

Tamura, Y., Endo, T., , Iijima, M. and Sesaki, H. (2009). Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J. Cell Biol. 185: 1029-1045

Sheng, X.R., Posenau, T., Gumulak-Smith, J.J., Matunis, E., Van Doren, M., Wawersik, M., 2009.  Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis.  Dev. Biol. 334:335-344.

McBride, C.E. and C.E. Machamer.  2009. A single tyrosine in the SARS coronavirus membrane protein is important for interaction with the spike protein.  J. Virol. 84:1891-1901.

Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN and Wilson KL. (2009) Barrier to Autointegration Factor proteome reveals chromatin-regulatory partners. PLoS One e7050. 

Tifft KE, Bradbury KA and Wilson KL. (2009) Tyrosine phosphorylation of nuclear membrane protein emerin by Src, Abl and other kinases. J Cell Science 122:3780-3790. 

Rahdar M., Inoue T., Meyer T., Zhang J., Vazquez F., and Devreotes P.N. “A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN” Proc. Natl. Acad. Sci. U S A. 106(2):480-5 (2009)

Braiterman, L., Nyasae, L., Guo, L., Bustos, R., Lutsenko, S., Hubbard, A. 2009. Apical targeting and golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B. Am. J. Physiol. Gastrointest. Liver Physiology, 296(2):G433-444.

Ewald, AJ, Werb, Z, Egeblad, M, “In vivo imaging of tumor – immune cell interactions,” Live Cell Imaging 2nd Edition, Cold Spring Harbor Laboratory Press, 2009

Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, and Espenshade PJ. 2009. C. neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol. Microbiol. 74:672-690.

Lee CY, Stewart EV, Hughes BT and Espenshade PJ. 2009. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J. 28:135-43.

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Chung, S.-Y., Vining, M.S., Bradley, P.L., Chan, C.-C., Wharton, K.A. and Andrew, D.J. (2009) Serrano (Sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genetics 5(11): e1000746. PMID: 19956736.

Kamimura, Y., Tang, M., and Devreotes, P.N. 2009 Assays for Chemotaxis and Chemoattractant-Stimulated TorC2 Activation and PKB Substrate Phosphorylation in Dictyostelium. In: Chemotaxis, Methods in Molecular Biology, vol. 571. (T. Jin and D. Hereld, eds.). Humana Press.

Tamura, Y., Harada, Y., Shiota, T., Yamano, K., Watanabe, K., Yokota, M., Yamamoto, H., Sesaki, H., and Endo, T. (2009). Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J. Cell Biol. 184: 129-141


Dikeman, D.A., Rivera Rosado, L.A., Horn, T.A., Alves, C.S., Konstantopoulos, K. and Yang, J.T. (2008).  α4β1 integrin regulates directionally persistent cell migration in response to shear flow stimulation.  Am. J. Physiol. Cell Physiol., 295, 151-159.  

Liu J, Desai A, Onuchic JN, Hwa T. 2008. An integrated mechano-biochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis. PNAS 2008; 105: 13752-13757.

Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, Walton K, Perera A, Staehling-Hampton K, Seidel CW, Li R. Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor. Cell. 2008;135:879-893.  

Egeblad* M, Ewald* AJ, Asketraud HA, Truitt M, Welm B, Bainbridge E, Peeters G, Krummel M, Werb Z, “Imaging stromal cells in different tumor microenvironments by spinning disk confocal microscopy”, Disease Models and Mechanisms. 2008 Sep/Oct; 1(2/3): 155-67. * = Co-First Authors. PMC2562195

Nakatsukasa, K., Huyer, G., Michaelis, S., and Brodsky J. L. (2008) Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein. Cell 132: 101-112

Lu, PF, Ewald, AJ, Werb, Z, Martin, G. Genetic mosaic analysis reveals FGF receptor 2 is required in terminal end buds during mammary gland branching morphogenesis. Developmental Biology, 2008 Sep 1; 321(1):77-87.

Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.* 2008. Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 18: 471-480. PMCID: PMC2361134

Hudon, S. E., Coffinier, C., Michaelis, S., Fong, L. G., Young, S. G., and Hrycyna, C. A. (2008) HIV-Protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Comm. 374:365-368

Kerman, B.E., Cheshire, A.M., Myat, M.M., and Andrew, D.J. (2008) Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.  Developmental Biology 320:  278-288. PMID: 18585700

Jensen, R.E. et al. (2008). What happens when Trypanosoma brucei leaves Africa. Trends Parasitol. 24: 428-431.

Chandran, S. and C.E. Machamer.  2008.  Acute perturbations in Golgi organization impact de novo sphingomyelin synthesis.  Traffic 9:1894-1904.

Inoue T. and Meyer T. “Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration” PLoS ONE 3(8), e3068 (2008)

Yamano K, Yatsukawa Y, Esaki M, Hobbs AE, Jensen RE, Endo T. (2008). Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import. J. Biol. Chem. 283(7): 3799-3807.

Ewald, AJ, Brenot, A, Duong, M, Chan, BC, Werb, Z. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Developmental Cell, 2008 Apr; 14(4): 570-81.

Tang, L., Franca-Koh, J., Xiong, Y., Chen, M-Y., Long, Y., Bickford, R.M., Knecht, D.A., Iglesias, P.A., and Devreotes, P.N. 2008 Tsunami, the Dictyostelium homolog of the Fused kinase is required for polarization and chemotaxis. Genes Dev. 22:2278-2290. PMCID: PMC2518819

Alder NN, Jensen RE, Johnson AE.  (2008) Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface. Cell 134: 439-450.

Barrowman, J., Hamblet, C., George, C.M., and Michaelis, S. (2008) Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. Mol. Biol. Cell 12:5398-5408

Metzger, M. B. Maurer, M. J., Dancy, B. M., and Michaelis, S. (2008) Degradation of a cytosolic protein requires ER-associated degradation (ERAD) machinery. J. Biol. Chem. 283:32302-32316

Kamimura, Y., Xiong, Y., Iglesias, P.A., Hoeller, O., Bolourani, P. and Devreotes, P.N. 2008 PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Bio. July 22; 18(14):1034-43. PMCID: PMC4018231

Alder NN, Sutherland J, Buhring AJ, Jensen RE, Johnson AE.  (2008) Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits. Mol. Biol. Cell 19: 159-170.

Hogue, B.G., and C.E. Machamer. 2008. Coronavirus structural proteins and virus assembly. Nidoviruses. Edited by S. Perlman, T. Gallagher, and E. Snijder. (ASM), pp. 179-200.

Fivaz M., Bandara S., Inoue T. and Meyer T. "Robust neuronal symmetry breaking by Ras-triggered local positive feedback" Current Biology 18, 44-50 (2008)

Kouros-Mehr, H, Bechis, SK, Slorach, EM, Littlepage, LE, Egeblad, M, Ewald, AJ, Pai, SY, Ho, IC, Werb, Z. Gata-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell, 2008, Feb; 13(2): 141-52.

Burg JS, Powell DW, Chai R, Hughes AL, Link AJ and Espenshade PJ. 2008. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metabolism 8:522-31.

Hughes BT and Espenshade PJ. 2008. Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J. 27:1491-1501.

Iglesias, P.A. and Devreotes, P.N. 2008 Navigating through models of chemotaxis. Curr. Opin. Cell Bio., 20(1):35-40.

Dunn, C.D. et al. (2008) Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol. Biol. Cell 19: 5387-5397.


Chen, L., Iijima, M., Tang, M., Landree, M.A. Huang, Y.E., Xiong, Y., Iglesias, P.A., Devreotes, P.N. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Developmental Cell. Developmental Cell. (2007) 12: 603-614.

Hammarlund, M., Palfreyman, M. T., Watanabe, S., Olsen, S., and Jorgensen, E. M. (2007). Open syntaxin docks synaptic vesicles. PLoS Biol. 5, e198. PMCID: PMC3048763.

Yoshino, R., Morio, T., Yamada, Y., Kuwayama, H., Sameshima, M., Tanaka, Y., Sesaki, H., and Iijima, M. Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium Eukaryot Cell. (2007) 6: 2419-2428. 

Fata, J, Mora, H, Ewald, AJ, Zhang, H, Yao, E, Werb, Z, Bissell, M. The MAPK ERK-1,2 pathway integrates distinct and antagonistic signals from TGF± and FGF7 in morphogenesis of mouse mammary epithelium. Developmental Biology, 2007, Jun 1; 306(1):193-207.

Cerveny, K.L. et al. (2007) Yeast mitochondrial division and distribution require the cortical Num1 protein. Dev. Cell 12: 363-375.

Sbodio, J.I. and C.E. Machamer.  2007.  Identification of a redox sensitive cysteine residue in GCP60 that regulates its interaction with golgin-160.  J. Biol. Chem 282:29874-29881.

Davis, A.J. et al. (2007) The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import. Mol. Biol. Cell 18: 475-486.

McBride, C.E., J. Li, and C.E. Machamer. 2007. The cytoplasmic tail of the spike protein of the severe acute respiratory syndrome coronavirus contains a novel endoplasmic reticulum retrieval signal that binds COPI and promotes interaction with membrane protein. J. Virol., 81:2418-2428.

Page-McCaw*, A, Ewald*, AJ, Werb, Z. Matrixmetalloproteinases and the regulation of tissue remodeling. Nature Reviews Molecular Cell Biology, 2007, Mar; 8(3): 221-33. *Co-First Authors.

Holaska JM and Wilson KL. (2007) An emerin ‘proteome’: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing and nuclear architecture. Biochemistry 46, 8897-908. 

Paumi, C. M., Menendez, J., Arnoldo, A, Engels, K, Iyer, K. R., Thaminy, S, Georgiev, O., Barral Y., *Michaelis, S, and *Stagljar, I. (2007) Mapping Protein-Protein Interactions for the Yeast ABC Transporter Ycf1p by Integrated Split-Ubiquitin Membrane Yeast Two-Hybrid (iMYTH) Analysis. Molecular Cell 26: 15-25. * Co-corresponding senior authors.

Sasaki, A.T., Janetopoulos, C., Lee, S., Charest, P.G., Takeda, K., Sundheimer, L.W., Meili, R., , Devreotes, P.N.and Firtel, R.A. 2007 G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J. Cell Bio. 178(2):185-191.

Meisinger, C. et al. (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 26: 2229-2239.

Cerveny, K.L., Studer, S.L., Jensen, R.E., and Sesaki, H. (2007). Yeast mitochondrial division and distribution requires the cortical Num1 protein. Developmental Cell. 12: 363-375.

Buszczak, M., Paterno, S., Lighthouse D., Bachman J., Plank J., Owen S., Skora A., Nystul T., Ohlstein B., Allen A., Wilhelm J., Murphy T., Levis B., Matunis. E., Srivali N., Hoskins R., Spradling A.  2007.  The Carnegie protein trap library: a versatile tool for Drosophila developmental studies.  Genetics 175:1501-1531. 

Nyasae, L., Bustos, R., Braiterman, L., Eipper, B., A. Hubbard. 2007. Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites. Am J Physiol Gastrointest Liver Physiol. 292(4):G1181-94.

Margalit A, Neufeld E, Feinstein N, Wilson KL, Podbilewicz B and Gruenbaum Y (2007).  Barrier to autointegration factor (BAF) blocks premature cell fusion and maintains adult muscle integrity in C. elegans. J Cell Biology 178:661-673. 

Peixoto, P.M. et al. (2007) Awaking TIM22: A dynamic ligand-gated channel for protein insertion in the mitochondrial inner membrane. J. Biol. Chem. 282: 18694-18701.

Cerveny, K.L., Tamura, Y., Zhang, Z., and Jensen, R.E. and Sesaki, H. (2007). Regulation of mitochondrial fusion and division. Trends Cell Biol. 17: 563-569.


Grazioli, A, Alves, C.S., Konstantopoulos, K and Yang, J.T. (2006). Defective blood vessel development and pericyte/pvSMC distribution in α4 integrin-deficient mouse embryos. Dev. Biol. 393,165-177.

Sesaki, H. Dunn, C.D., Iijima, M., Shepard, K.A., Yaffe, M.P., Machamer, C.E., and Jensen, R.E. (2006). Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J. Cell Biol. 173: 651-658. 

Somesh, B.P., Vlahou, G., Iijima, M., Insall, R.H., Devreotes, P.N., Rivero, F. RacG regulates morphology, phagocytosis and chemotaxis. Eukaryot Cell. (2006) 5: 1648-1663.

Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. PMCID: PMC2474462

Hicks, S.W., T.A. Horn, J.M. McCaffery, D.M. Zuckerman,and C.E. Machamer. 2006. Golgin-160 promotes cell surface expression of the beta-1-adrenergic receptor. Traffic 7:1666-1677.

Williams, D., S.W. Hicks, C.E. Machamer, and J.E. Pessin. 2006. Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes., Molec. Biol. Cell 17:5346-5355.

Zastrow MS, Flaherty DB, Benian GM and Wilson KL (2006). Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. J. Cell Science 119:239-249.

Montes de Oca R, Lee KK and Wilson KL (2006). Binding of barrier-to-autointegration factor (BAF) to histone H3 and selected linker histones including H1.1.  J Biological Chemistry 280:42252-62

Terry, N.A, Tulina, N., Matunis, E., DiNardo S.  2006.  Novel regulators revealed by profiling Drosophila testis stem cells within their niche.  Dev. Biol. 294:246-257. 

Sbodio, J.I., S.W. Hicks, D. Simon, and C.E. Machamer. 2006. GCP60 preferentially interacts with a caspase-generated golgin-160 fragment. J. Biol. Chem. 281:27924-27931.

Suh BC*, Inoue T*, Meyer T, and Hille B. “Rapid chemically-induced changes of PtdIns(4,5)P2 gate KCNQ ion channels” Science 314, 1454-1457 (2006) (*Contributed Equally) Note: “Perspectives” (Science 314, 1402-1403 (2006)), “Editor’s Choice” (Science STKE 364, tw410 (2006)), “Spotlight” (ACS Chem. Biol. 1, 608 (2006)), “Research Highlights” (Nature Methods 4, 7 (2007))

Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, and Meyer T. “PI(3,4,5)P3 and PI(4,5)P2 lipids target Ras, Rho, Arf and Rab GTPases to the plasma membrane” Science 314, 1458-1461 (2006)

Girard, K.D., Kuo, S.C., and Robinson, D.N. (2006) Dictyostelium myosin-II mechanochemistry promotes active behavior of the cortex on long time-scales. PNAS 103, 2103-2108

Abrams, E.W., Mihoulides, W.K. and Andrew, D.J. (2006) Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4áSG1 and PH4áSG2. Development 133: 3517-3527. PMID: 16914497.

Jensen, R.E. and Sesaki, H. (2006) Ahead of the curve: mitochondrial fusion and phospholipase D. Nat. Cell Biol. 8:1215-2157.


Song S, Ewald, AJ, Stallcup B. Werb, Z. and G. Bergers. PDGFR±+ perivascular progenitor cells in tumors regulate pericyte differentiation and vascular survival. Nature Cell Biology, 2005, Sep; 7(9) :870-9. Must Read 6.0 on Faculty of 1000, 10/28/05.

Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P.N. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Developmental Cell. (2005) 8: 467-477.

Zhang W., Robinson DN.* Balance of actively generated contractile and resistive forces controls cytokinesis dynamics. Proc. Natl. Acad. Sci. USA 2005; 102(20):7186-7191. PMCID: PMC1129136

Abrams, E.W. and Andrew, D.J. (2005) CrebA regulates secretory activity in the salivary gland and epidermis.  Development 132: 2743-2758. PMID: 15901661

Youn, S., E.W. Collisson, and C.E. Machamer. 2005. Contribution of trafficking signals in the cytoplasmic tail of the infectious bronchitis virus spike protein to virus infection. J. Virol. 79 13209-13217.

Pendleton, A.R., and C. E. Machamer. 2005. Infectious bronchitis virus 3a protein localizes to a unique punctate domain of the smooth endoplasmic reticulum. J. Virol.,79:6142-6151.

Mallampalli, M. P., Huyer, G., Bendale, P., Gelb, M. H., and Michaelis, S. (2005) Inhibiting Farnesylation Reverses the Nuclear Morphology Defect in a HeLa Cell Model for Hutchinson-Gilford Progeria Syndrome, Proc Natl. Acad Sci. USA 102:14416-14421.

Young, S. G. Fong, L., and Michaelis, S.  (2005) Prelamin A, Zmpste24, misshapen cell nuclei, and progeria- new evidence suggesting that protein farnesylation could be important for disease pathogenesis.  Journal of Lipid Research 46:2531-2558.

Wawersik, M., Milutinovich, A. Matunis, E., Williams, B. Van Doren, M.  2005.  Somatic control of germline sexual differentiation is mediated by the JAK/STAT pathway. Nature 436:563-567.  

Hicks, S.W. and C.E. Machamer. 2005. Golgi structure in stress sensing and apoptosis. Biochim. Biophys. Acta 1744:406-414.

Maag, R., M. Mancini,R, A. Rosen and C. E. Machamer. 2005. Caspase-resistant golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. Molec. Biol. Cell 16:3019-2027.

Hicks, S.W. and C.E. Machamer. 2005. Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST. J. Biol. Chem 280:28944-28951.

Inoue T, Heo WD, Grimley JS, Wandless TJ, and Meyer T. “Inducible translocation strategies to rapidly activate and inhibit small GTPase signaling pathways” Nature Methods 2, 415-418 (2005)

Guo, Y, L. Nyasae, L. T. Braiterman, and A. L. Hubbard. 2005. N-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Amer J. Physiol., GI/Liver 289(5):G904-16.

Hughes AL, Todd BL, Espenshade PJ. 2005. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120:831-842.


Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8951-6. PMC428453

Brawley, C, Matunis, E. 2004. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivoScience 304:1331-1334.

Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F., Devreotes, P.N. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J. Biol. Chem. (2004) 16: 16606-16613.

Ewald, AJ, Peyrot, S, Tyszka, JM, Fraser, SE, Wallingford, J. Regional requirements for Dishevelled signaling during Xenopus gastrulation: Separable effects on blastopore closure, mesendoderm internalization, and archenteron formation. Development, 2004, Dec Part 2; 131(24): 6195-6209.

Girard, K.D., Chaney, C., Delannoy, M., Kuo, S.C., and Robinson, D.N. (2004) Dynacortin contributes to cortical viscoelasticity and helps define the shape changes of cytokinesis. EMBO J 23(7), 1536-46


Wallenfang MR, Matunis E.  2003.  Developmental biology. Orienting stem cells.  Science. 301: 1490-1.  PMID: 12970553.

Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes” Chem. Biol. 10, 503-509 (2003) Note: “Cover art”

Bradley, P.L., Myat, M.M., Comeaux, C. and Andrew, D.J. (2003) Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.  Developmental Biology 257:  249-262. PMID: 12729556

Kupfer, A. and Kupfer, H. (2003) Imaging immune cell interactions and functions: SMACs and the immunological synapse. Seminars in Immunology 19:4712-4722.

Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P.N., Snyder, S.H. Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions. Cell. (2003) 114: 559-572.

Chen, H, Detmer, SA, Ewald AJ, Griffin, EE, Fraser SE, and Chan, DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Journal of Cell Biology, 2003, Jan 20; 160(2): 189-200.

McGrath, J.L., Eungdamrong, J., Fisher, C.I., Peng, F., Mahadevan, L., Mitchison, T.J., and Kuo, S.C. (2003) The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol 13, 329-332


Pinco, K. A., He W., and Yang, J. T. (2002). α4β1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol. Biol. Cell 13, 3203-3217.

Sengbusch, J.K., He W., Pinco, K.A. and Yang, J.T. (2002). Dual functions of α4β1 integrin in epicardial development: initial migration and long term attachment. J. Cell Biol.157, 873-882. 

Iijima, M., Huang, Y.E., Devreotes, P.N. Temporal and spatial regulation of chemotaxis. Developmental Cell. (2002) 4; 469-478.

Freiberg, B. A., Kupfer, H., Maslanik, W., Delli, J., Kappler, J., Zaller, D.M. and Kupfer, A. (2002) Staging and resetting T cell activation in SMACs. Nat. Immunol. 18:6201-6208.

Myat, M.M. and Andrew, D.J. (2002) Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Cell 111:879-891. PMID: 12526813.

Iijima, M. and Devreotes, P. N. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610 (Cover).


Sesaki, H. and Jensen, R.E. (2001). UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol. 152:1123-34. 

Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor” Chem. Biol. 8, 9-15 (2001)

Bradley, P.L. and Andrew, D.J. (2001) ribbon encodes a BTB-containing transcription factor required for directed cell migration.  Development 128: 3001-3015. PMID: 11532922

Tulina, N., Matunis, E. 2001.  Control of Stem cell self-renewal in Drosophila  spermatogenesis by Jak-STAT signaling.  Science 294: 2546-2549.

Potter, T.A., K. Grebe, B. Freiberg, and Kupfer, A. (2001) Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 92:819-828.

Wallingford, JB, Ewald, AJ, Harland, RM and Fraser, SE. Calcium signaling during convergent extension in Xenopus. Current Biology, 2001, May 1; 11(9):652-661. Selected for Cover.

Janetopoulos, C., Jin, T. and Devreotes, P.N. 2001. Receptor mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411.


Robinson DN*, Spudich JA. Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium cytokinesis mutant. J. Cell Biol. 2000; 150(4):823-838. PMCID: PMC2175282

Myat, M.M. and Andrew, D.J. (2000) Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia.  Development 127: 679-691. PMID: 10648227

Myat, M.M. and Andrew, D.J. (2000) FORK HEAD prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands.  Development 127: 4217-4226. PMID: 10976053

Kupfer, A. (2000) Breaking up receptor alliances: the parting of CD3 and CD4. Nature Medicine 16:2248-2254.

Kuo, S.C., and McGrath, J. L. (2000) Steps and fluctuations of Listeria monocytogenes during actin-based motility. Nature 407, 1026-9

Yamada, S., Wirtz, D., and Kuo, S.C. (2000) Mechanics of living cells measured by laser tracking microrheology (LTM). Biophys. J. 78, 1736-47.


Sesaki, H. and Jensen, R.E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147: 699-706. 

Parent, C. and Devreotes, P.N. 1999. A Cell's Sense of Direction. Science, 284, 765-770.


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Chen MY, Long Y, Devreotes PN. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 1997 Dec 1;11(23):3218-31. PMC316743

Xiao Z, Zhang N, Murphy DB, Devreotes PN. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J Cell Biol. 1997 Oct 20;139(2):365-74. PMC2139806.

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Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol. 1994 Sep;126(6):1537-45. PMC2290948


Lilly P, Wu L, Welker DL, Devreotes PN. A G-protein beta-subunit is essential for Dictyostelium development. Genes Dev. 1993 Jun;7(6):986-95. PMID: 8099335.


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