Publications

2020

Raynor J, Liu C, Dhungana Y, Guy C, Chapman N, Shi H, Neale G, Sesaki H, Chi H. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. J Exp Med. 2020. In press.

Jin, Q., Bhatt, A., Pagaduan, P.V., Chen, X., West-Foyle, H., Liu, J., Hou, A., Berkowitz, D., Kuo, S.C., Askin, F.B., Nguyen, T.D., Gracias, D.H., and Romer, L. (2020) Biomimetic human small muscular pulmonary arteries.  Sci. Adv., in press

Murata D, Arai K, Iijima M, Sesaki H. Mitochondrial Division, Fusion and Degradation. J Biochem. 2020;167:233-241

Zhou Z, Torres M, H Sha, Halbrook CJ., Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter A, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard D, Qi L. Regulation of endoplasmic reticulum-mitochondria contacts and mitochondrial dynamics by Sel1L-Hrd1 ERAD during thermogenesis. Science. 2020. In press.

Wang H, Li Y, Yang J, Duan X, Kalab P, Sun S, and Li R. Symmetry breaking in hydrodynamic forces drive meiotic spindle rotation in mammalian oocyte. Sci Adv Advance In press

Srivastava V, Balaban AE. Robinson DN.* Cytokinesis. In Joseph Jez (ed) The Encyclopedia of Biological Chemistry 3rd Edition, 2020; Academic Press, Waltham, MA., In press.

Hinge A, He J, Bartram J, Javier J, Xu J, Fjellman E, Sesaki H, Li T, Yu J, Wunderlich M, Mulloy J, Kofron M, Salomonis N, Grimes HL, Filippi MD. Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020 Mar 5;26(3):420-430

Hasnain Z, Fraser AK, Georgess D, Choi A, Macklin P, Bader JS, Peyton SR, Ewald AJ, Newton PK. OrgDyn: Feature and Model Based Characterization of Spatial and Temporal Organoid Dynamics. Bioinformatics 2020 Feb 24[Online ahead of print]. DOI: 10.1093/bioinformatics/btaa096.

Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, Devreotes PN (2020). Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proc Natl Acad Sci U S A, 117(8), 4158-4168. doi: 10.1073/pnas.1917938117.

Crews DC, Wilson KL, Sohn J, Kabacoff CM, Poynton SL, Murphy LR, Bolz J, Wolfe A, White PT, Will C, Collins C, Gauda E, Robinson DN*. Helping scholars overcome socioeconomic barriers to medical and biomedical careers: Creating a pipeline initiative.  Teach. Learn. Med. 2020; 1-12. DOI: 10.1080/10401334.2020.1729161.

Pei-Hsun Wu*, Daniele M. Gilkes, Jude M. Phillip, Akshay Narkar, Thomas Wen-Tao Cheng, Jorge Marchand, Meng-Horng Lee, Rong Li, Denis Wirtz*. 2020. Single-cell morphology encodes metastatic potential. Sci. Adv. 6, eaaw6938 (2020) DOI: 10.1126/sciadv.aaw6938

Padmanaban V, Tsehay Y, Cheung KJ, Ewald AJ, Bader JS. Between-tumor and Within-Tumor Heterogeneity in Invasive Potential. PLOS Comput Biol, 16 (1), e1007464, 2020 Jan 21.

Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ. Twist1-induced epithelial dissemination requires Prkd1signaling. Cancer Res, 2020 Jan 15, 80 (2), 204-218. 

Duan X, Li Y, Yi K, Guo F, Wang H, Wu PH, Yang J, Mair DB, Morales EA, Kalab P, Wirtz D, Sun SX, Li R. Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes. Nat Commun. 2020 Jan 14;11(1):277. doi: 10.1038/s41467-019-14068-3.

Ruan L, Wang Y, Zhang X, Tomaszewski A, McNamara JT, Li R. 2020. Mitochondria-associated proteostasis. Ann Rev Biophys. 2020 Jan 13. doi: 10.1146/annurev-biophys-121219-081604. [Epub ahead of print].

2019

Yang J, Duan X, Fraser AK, Choudhury MI, Ewald AJ, Li R, Sun SX. Microscale Pressure Measurements Based on an Immiscible Fluid/Fluid Interface. Sci Rep. 2019 Dec 27;9(1):20044. doi: 10.1038/s41598-019-56573-x.

Cao Y, Ghabache E, Miao Y, Niman C, Hakozaki H, Reck-Peterson SL, Devreotes PN, and Rappel W-J.  2019. A minimal computational model for three-dimensional cell migration. J. R. Soc. Interface 16:20190619. http://dx.doi.org/10.1098/rsif.2019.0619

Pal DS*, Li X*, Banerjee T, Miao Y, Devreotes PN. 2019. The Excitable Signal Transduction Networks: Movers and Shapers of Eukaryotic Cell Migration. Int. J. Dev. Biol. 63(8-9-10):407-416. doi: 10.1387/ijdb.190265pd. *Equal contribution.

Li X, Miao Y, Pal DS, Devreotes PN. Excitable networks controlling cell migration during development and disease. Semin Cell Dev Biol. 2019 Dec 10;. doi: 10.1016/j.semcdb.2019.11.001. [Epub ahead of print] Review. PubMed PMID: 31836289; NIHMSID:NIHMS1546309

Thompson DJ et al. Genetic predisposition to mosaic Y chromosome loss in blood. Nature. 2019 Nov;575(7784):652-657. doi: 10.1038/s41586-019-1765-3. Epub 2019 Nov 20.

Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O’Rourke B, He L. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Rep. 2019 Nov 5;29(6):1511-1523.

Devreotes P (2019). Moving toward molecular mechanisms for chemotaxis in eukaryotic cells. Mol Biol Cell, 30(23), 2873-2877, 2019 Nov 1. doi: 10.1091/mbc.E19-07-0393. PMC6822590.

Li R. I am an American scientist of the world. Mol Biol Cell. 2019 Nov 1;30(23):2865-2866. doi: 10.1091/mbc.E19-07-0389.

Itoh K, Murata D, Kato T, Yamada T, Araki Y, Saito A, Adachi Y, Igarashi A, Li S, Pletnikov M, Huganir RL, Watanabe S, Kamiya A, Iijima M, Sesaki H. Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. Elife. 2019 Oct 11;8. pii: e44739.

Puddu F, Herzog M, Selivanova A, Wang S, Zhu J, Klein-Lavi S, Gordon M, Meirman R, Millan-Zambrano G, Ayestaran I, Salguero I, Sharan R, Li R, Kupiec M, Jackson SP. Genome Architecture and Stability in the Saccharomyces Cerevisiae Knockout Collection. Nature 2019 Sep;573(7774):416-420. doi: 10.1038/s41586-019-1549-9. Epub 2019 Sep 11.

Drutovic D, Duan X, Li R, Kalab P, Solc P. RanGTP and Importin β Regulate Meiosis I Spindle Assembly and Function in Mouse Oocytes. EMBO J. 2020 Jan 2;39(1):e101689. doi: 10.15252/embj.2019101689. Epub 2019 Oct 16.

Surcel A, Schiffhauer ES, Thomas DG, Zhu Q, DiNapoli K, Herbig M, Otto O, West-Foyle H, Jacobi A, Kräter M, Plak K, Guck J, Jaffee EM, Iglesias PA, Anders RA, Robinson DN. Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14. Cancer Res. 2019; 79: 4665-4678.

Kothari P, Johnson C, Sandone C, Iglesias PA, Robinson DN. How the mechanobiome drives cell behavior, viewed through the lens of control theory. J. Cell Sci. 2019; 132:1-10. jcs234476.

Spear, E.D, Alford, R.F., Babatz, T.D., Wood, K., Mossberg, O.  Shilgardi, K., Odinammadu, K Gray, J., and Michaelis, S. (2019) A Humanized Yeast System to Analyze Cleavage of Prelamin A by ZMPSTE24. Methods 157:47-55

Nakamura H, DeRose R, Inoue T. “Harnessing biomolecular condensates in living cells” Journal of Biochemistry (in press, 2019)

Wells, M.B. and Andrew, D.J. (2019). Anopheles Salivary Gland Architecture Shapes Plasmodium Sporozoite Availability for Transmission. mBio. 2019 Aug 6;10(4):e01238-19. doi: 10.1128/mBio.01238-19.PMID: 31387905.

Johnson, D.M. and Andrew, D.J. (2019) Role of tbc1 in Drosophila embryonic salivary glands.  BMC Cell and Molec. Biol  20:19

Suresh, K., K. Carino, L. Johnston, L. Servinsky, C. Machamer, T. Kolb, H. Lam, S. Dudek, S. An, M. Rane, L. Shimoda, and M. Damarla. 2019. A non-apoptotic, endothelial barrier-protective role for caspase 3. Amer. J. Physiol. Lung 316)6):L1118-L1126. 

Westerbeck, J.W. and C.E. Machamer. 2019. The infectious bronchitis virus coronavirus envelope protein alters Golgi pH to protect spike protein and promote release of infectious virus. J. Virol.93(11):1-15. PMCID: PMC6532078

Padmanaban V, Suhail Y, Bader JS, Ewald AJ, “E-cadherin suppresses invasion and promotes metastasis in multiple breast cancer models,” Accepted in Principle at Nature, 2019.

Adachi Y, Iijima M, Sesaki H. An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid. Small GTPases. 2018 Nov 2;9(6):472-479.

Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer and David F. Kashatus. Drp1 promotes KRas-driven metabolic changes to drive pancreatic tumor growth. Cell Reports. In press

Yamada T, Dawson TM, Yanagawa T, Iijima M, Sesaki H. SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy. Autophagy. 2019; In press.

Michael P. Catanzaro, Ashley Weiner, Amanda Kaminaris, Fei Cai, Cairong Li, Fengyi Zhao, Satoru Kobayashi, Tamayo Kobayashi, Yuan Huang, Hiromi Sesaki, Qiangrong Liang. Doxorubicin-induced Cardiomyocyte Death is Mediated by Unchecked Mitochondrial Fission and Mitophagy. FASEB J. In press.

Senoo H, Kamimura K, Kimura R, Nakajima A, Sawai S, Sesaki H, Iijima M. Phosphorylated Rho-GDP directly activates mTORC2 Kinase toward AKT through dimerization with Ras-GTP to regulate cell migration. Nature Cell Biology. 2019; Epub ahead of Print

Arun A, Eddings CR and Wilson KL (2019) Novel missense alleles of SIGMAR1 as tools to understand emerin-dependent gene silencing in response to cocaine. Exp. Biology & Medicine (in press) 

Surcel A, Robinson DN.* Meddling with myosin’s mechanobiology in cancer. Proc. Natl. Acad. Sci. U.S.A. 2019; 116(31): 15322-15323.

Andrew, D.J., Chen, E.H., Manoli, D.S., Ryner, L.C. and Arbeitman, M.N. (2019) Sex and the single fly: A perspective on the career of Bruce S. Baker. Genetics 212(2) 365-376

Paul P, Ramachandran S, Xia S, Unruh JR, Conkright-Fincham J, Li R. 2019. Dopamine receptor antagonists as potential therapeutic agents for ADPKD. PLoS One. 2019 May 6;14(5):e0216220. doi: 10.1371/journal.pone.0216220. eCollection 2019

Tsai H-J, Nelliat AR, Choudhury MI, Kucharavy A, Bradford WD, Cook ME, Kim J, Mair DB, Sun SX, Schatz MC & Li R. 2019. Hypo-osmotic-like stress underlies general cellular defects of aneuploidyNature (2019) https://doi.org/10.1038/s41586-019-1187-2.

Hickey JW, Dong Y, Chung JW, Salathe SF, Pruitt HC, Li X, Chang C, Fraser AK, Bessell CA, Ewald AJ, Gerecht S, Mao HQ, Schneck JP, ” Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy,” Adv Mater. 2019 Apr 10:e1807359. 

Dharmaraj T, Guan YC, Liu J, Badens C, Gaborit B and Wilson KL (2019) Rare BANF1 variants and relatively frequent EMD variants including ‘healthy lipid’ emerin p.D149H in the ExAC cohort. Front. Cell Dev. Biol. 05 April 2019 https://doi.org/10.3389/fcell.2019.00048

Palma E, Ma X, Riva A, Iansante V, Dhawan A, Wang S, Ni HM, Sesaki H, Williams R, Ding WX, Chokshi S. Dynamin-1-Like Protein Inhibition Drives Megamitochondria Formation as an Adaptive Response in Alcohol-Induced Hepatotoxicity. Am J Pathol. 2019 Mar;189(3):580-589.

Schiffhauer ES, Ren Y, Iglesias V, Kothari P, Iglesias PA, Robinson DN*. Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics. J. Cell Biol. 2019; 218(3): 895-908. (Includes 4 pages of Supplemental Figures)

Gutiérrez MS, Campusano S, González AM, Gómez M, Barahona S, Sepúlveda D, Espenshade PJ, Fernández-Lobato M, Baeza M, Cifuentes V, Alcaíno J. Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in Xanthophyllomyces dendrorhous. Front Microbiol. 2019 Mar 29;10:586. doi: 10.3389/fmicb.2019.00586. eCollection 2019.

Miao Y, Battacharya S, Banerjee T, Abudaker-Sharif B, Long Y, Inoue T, Iglesias P and Devreotes P. (2019). Wave patterns organize cellular protrusions and control cortical dynamics. Molecular Systems Biology 15(3). DOI 10.15252/msb.20188585| Published online 11.03.2019.

Kothari P, Srivastava V, Aggarwal V, Tchernyshyov I, Van Eyk J, Ha T, and Robinson DN*. Contractility kits promote assembly of the mechanoresponsive cytoskeletal network. J. Cell Sci. 2019; 132(2): 1-12. (Cover article; includes 11 pages of Supplemental Figures and Tables; first author was featured in a “First Person – Priyanka Kothari” interview, J. Cell Sci 2019 132: jcs229195)

Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G. (2019).  Probing the function of metazoan histones with a systematic library of H3 and H4 mutants.  Dev Cell Feb 11;48(3):406-419.

Li L, Knutsdottir H, Hui K, Weiss MJ, He J, Philosophe B, Cameron AM, Wolfgang CL, Pawlik TM, Ghiaur G, Ewald AJ, Mezey E, Bader JS, Selaru FM, “Human primary liver cancer organoids reveal intra-tumor and inter-patient drug response heterogeneity,” JCI Insight. 2019 Jan 24;4(2). pii: 121490.

Schiffhauer ES, Ren Y, Iglesias V, Kothari P, Iglesias PA, Robinson DN. 2019. Myosin IIB assembly-state determines myosin IIB mechanosensitive dynamics. J. Cell Biol. In press.

Kojima R, Kakimoto Y, Furuta S, Itoh K, Sesaki H, Endo T, Tamura Y. Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport. Cell Rep. 2019 Jan 15;26(3):518-528.

2018

Wu ZH, Su MH, Tong CS, Wu M, Liu J. 2018. Membrane shape-mediated wave propagation of cortical protein dynamics. Nature Communications 9(1): 136.

Watanabe, S., Mamer, L.E., Raychaudhuri, S., Luvsanjav, D., Eisen, J., Trimbuch, T., Söhl-Kielczynski, B., Fenske, P., Milosevic, I., Rosenmund, C., and Jorgensen, E.M. (2018) Synaptojanin and endophilin mediate neck formation during ultrafast endocytosis. Neuron 98, 1184-1197.

Mair, Devin B., Heather M. Ames, and Rong Li. “Mechanisms of invasion and motility of high-grade gliomas in the brain.” Molecular biology of the cell 29.21 (2018): 2509-2515

Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, and Ueda M. (2018). Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis. Biochemical and Biophysical Research Communications. Nov 16. pii: S0006-291X(18)32435-5. doi: 10.1016/j.bbrc.2018.11.029. [Epub ahead of print] PubMed PMID: 30454895.

Genin EC, Bannwarth S, Lespinasse F, Ortega-Vila B, Fragaki K, Itoh K, Villa E, Lacas-Gervais S, Jokela M, Auranen M, Ylikallio E, Mauri-Crouzet A, Tyynismaa H, Vihola A, Aug G, Cochaud C, Sesaki H, Ricci JE, Udd B, Vives-Bauza C, Paquis-Flucklinger V. Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases. Neurobiol Dis. 2018 Nov;119:159-171.

Wilson KL (2018) Nuclear import pathway key to rescuing dominant progerin phenotypes. Science Signaling 11(537). pii: eaat9448

Liu X, Cheng Y, Wang Z, Abraham J, Wang Z, Ke X, Yan R, Zhang G, Khashab M, Shin EJ, McNamara G, Ewald AJ, Lin DC, Liu Z, Meltzer S, “Modeling Wnt signaling in Barrett’s neoplasia using human Barrett’s epithelial organoids and CRISPR-Cas9 genome editing,” Cancer Lett. 2018 Nov 1;436:109-118.

Simon DN, Wriston A, Florwick A, Fan Q, Dharmaraj T, Shabanowitz J, Peterson SB, Gruenbaum Y, Carlson CR, Gronning-Wang LM, Hunt DF and Wilson KL (2018) OGT (O-GlcNAc transferase) selectively modifies multiple residues unique to lamin A. Cells 7:44

Greenspan, L.J., and Matunis, E.L. (2018).  Retinoblastoma intrinsically regulates niche cell quiescence, identity, and niche number in the adult Drosophila testis. Cell Reports 25;24(13):3466-3476.

Liu Y and Robinson D*. Recent advances in cytokinesis: Understanding the molecular underpinnings. F1000Research 2018; 7(F1000 Faculty Rev): 1849.

Kriebel PW, Majumdar R, Jenkins LM, Senoo H, Wang W, Ammu S, Chen S, Narayan K, Iijima M, Parent CA. Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals. J Cell Biol. 2018;217(8):2891-2910.

Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Kato T, Araki Y, Huganir RL, Dawson TM, Yanagawa T, Okamoto K, Iijima M and Sesaki H. (2018). Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent mitophagy and mitigates nonalcoholic fatty liver disease. Cell Metab. 2018 Oct 2;28(4):588-604.e5.

Sirka OK, Shamir ER, Ewald AJ, “Myoepithelial cells are a dynamic barrier to epithelial dissemination,” Journal of Cell Biology, 2018 Oct 1;217(10):3368-3381.

Kim DH, Ewald AJ, Park JS, Kshitiz, Kwak M, Gray RS, Su CY, Seo J, An SS, Levchenko A, “Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread”, Sci Rep. 2018 Sep 21;8(1):14210. 

Bettridge KE, Cook AL, Ziegelstein RC, Espenshade PJ. A Scientist’s Oath. Mol Cell. 2018 Sep 20;71(6):879-881. doi: 10.1016/j.molcel.2018.08.026.

Li X, Edwards M, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, and Devreotes PN. 2018. Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration. PNAS published ahead of print Sept. 7, 2018. https://doi.org/10.1073/pnas.1809039115

Riley JS, Quarato G, Cloix C, Lopez J, O’Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO J. 2018 Sep 3;37(17). pii: e99238.

Hennings TG, Chopra DG, DeLeon ER, VanDeusen HR, Sesaki H, Merrins MJ, Ku GM. In Vivo Deletion of Beta-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption. Endocrinology. 2018 Sep 1;159(9):3245-3256. 

Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H. A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane. J Biol Chem. 2018 Jul 27;293(30):11809-11822.

Yamada T, Adachi Y, Yanagawa T, Iijima M, Sesaki H. p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. Neurochem Int. 2018 Jul;117:77-81

Igarashi, A., Itoh, K., Yamada, T., Adachi, Y., kato, T., Murata, D., Sesaki, H., and Iijima, M. (2018).  Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility. J Biol Chem. 2018 Jun 15;293(24):9292-9300

Kwon D, Sesaki H, Kang SJ. 2018. Intracellular calcium is a rheostat for the STING signaling pathway. Biochem Biophys Res Commun. 2018 Jun 2;500(2):497-503.

Naoto Takada, Tomoki Naito, Inoue T, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. “Enhanced phospholipid flipping by P4-ATPase promotes membrane deformation.” 2018. EMBO Reports (in press). 

Cuei-Ling Wang, Yu-Chen Chang, Ya-Chu Chang, Shi-Rong Hong, Chun-Yu Lin, Ning Hsu, Hsiao-Chi Cheng, Yueh-Chen Chiang, Wei-En Huang, Nathan C. Shaner, Rajat Rohatgi, Inoue T, Yu-Chun Lin. (2018).“Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.”Nature Communications 2018:9:1732:1-13

Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M. 2018. MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress. Cell Rep. 2018 Apr 24;23(4):1005-1019.

Spear E. D,. Hsu E.-T., Nie L., Carpenter E.P., Hrycyna C.A., and Michaelis S. (2018). ZMPSTE24 Missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or  protein stability.  Disease Models and Mechanism 11:1-12 PMID 29794150

Worman, H. J. and Michaelis, S. (2018). Permanently Farnesylated Prelamin A, Progeria and Atherosclerosis.  Circulation 183:283-6 PMC6056017

Preston G. M., Guerriero C. J., Metzger M.B., Michaelis S. and Brodsky J.L. 2018. Substrate insolubility dictates Hsp104-dependent endoplasmic reticulum associated degradation.  Mol. Cell 70:242-253 

Jouroukhin Y, Kageyama Y, Misheneva V, Shevelkin A, Andrabi S, Prandovszky E, Yolken RH, Dawson VL, Dawson TM, Aja S, Sesaki H, Pletnikov MV. 2018. DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. Transl Psychiatry. 2018 Apr 12;8(1):76. doi: 10.1038/s41398-018-0123-9.

Neumann NM, Perrone MC, Veldhuis JH, Huebner RJ, Zhan H, Devreotes PN, Brodland GW, Ewald AJ. 2018. Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell. 2018 Apr 9;45(1):67-82.e6. doi: 10.1016/j.devcel.2018.03.011. PMID: 29634937

Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George SP, Ahrorov A, Hou JK, Herron AJ, Sesaki H, Khurana S. 2018. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation Gastroenterology. 2018 Apr;154(5):1405-1420

Gajendiran P, Vega LI, Itoh K, Sesaki H, Vakili MR, Lavasanifar A, Hong K, Mezey E, Ganapathy-Kanniappan S. 2018. Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin. J Cell Mol Med. 2018 Apr;22(4):2210-2219. doi: 10.1111/jcmm.13501. Epub 2018 Feb 4.

Ewald AJ. 2018. Metastasis inside-out: dissemination of cancer cell clusters with inverted polarity. EMBO J. 2018 Apr 3;37(7). pii: e99144. doi: 10.15252/embj.201899144. Epub 2018 Mar 9. No abstract available. PMID:29523585

Sisk, J.M., M.B. Frieman and C.E. Machamer. 2018. Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors. J. Gen. Virol., Mar 20. doi: 10.1099/jgv.0.001047. [Epub ahead of print]

Gilbert, C.E., E. Sztul and C.E. Machamer. 2018. Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins. Molec. Biol. Cell, E17-11-0622. doi: 10.1091/mbc.E17-11-0622. [Epub ahead of print]

Edwards M, Cai H, Abubaker-Sharif  B, Long Y, Lampert T, and Devreotes PN. 2018. Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideumProc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3722-E3730. doi: 10.1073/pnas.1710480115. Epub 2018 Mar 30.

Neumann NM, Perrone MC, Veldhuis JH, Huebner RJ, Zhan H, Devreotes PN, Brodland GW, and Ewald AJ. 2018. Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drives radial intercalation and tube elongation. Dev Cell Apr 9;45(1):67-82.e6. doi: 10.1016/j.devcel.2018.03.11.

Chou FS, Li R, Wang PS. Molecular components and polarity of radial glial cells during cerebral cortex development. 2018. Cell Mol Life Sci. 2018 Mar;7 5(6):1027-1041. doi: 10.1007/s00018-017-2680-0.

McDonald NALind ALSmith SELi RGould KL. Nanoscale architecture of the Schizosaccharomyces pombecontractile ring. Elife. 2017 Sep 15; 6. pii: e28865. doi: 10.7554/eLife.28865.

Jin Zhu, Hung-Ji Tsai, Molly R. Gordon, Rong Li. Cellular Stress Associated with Aneuploidy; Dev Cell. 2018 Feb 26;44(4):420-431. doi: 10.1016/j.devcel.2018.02.002.

Linhao Ruan, Xi Zhang, Rong Li. Recent insights into the cellular and molecular determinants of aging. J Cell Sci. 2018 Feb 2; 131(3). pii: jcs210831. doi: 10.1242/jcs.210831

Perry HM, Huang L, Wilson RJ, Bajwa A, Sesaki H, Yan Z, Rosin DL, Kashatus DF, Okusa MD. 2018. Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI. J Am Soc Nephrol. 2018 Jan;29(1):194-206

2017

Manning, L., Sheth, J., Bridges, S., Saadin, A., Odinammadu, K., Andrew, D., Spencer, S., Montell, D. and Starz-Gaiano, M. (2017) A hormonal cue promotes timely follicle cell migration by modulating transcription profiles. Mech. Dev. 148: 56-68.

Pushpendra Singh, Rong Li. Emerging roles for sphingolipids in cellular aging. Curr Genet. 2017 Dec 19. doi: 10.1007/s00294-017-0799-z. 

Thomas DG, Robinson DN. 2017. The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis. Sem. Cell Dev. Biol. 2017; 71: 68-74.

Nishida K, Brune KA, Putcha N, Mandke P, O’Neal WK, Shade D, Srivastava V, Wang M, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye V.  2017. Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension. Am. J. Physiol. – Lung Cell Mol. Physiol. 2017; 313(3): L581-L591.

Miao C, Schiffhauer ES, Okeke E, Robinson DN, Luo T. 2017. Parallel compression is a fast, low-cost assay for the high throughput screening of mechanosensory cytoskeletal proteins in cells. ACS Appl. Mater. Interfaces 2017; 9(34): 28168-28179. ACS Appl. Mater. Interfaces 2017; 9(34): 28168-28179

Nakamura H, Lee AA, Afshar AS, Lin YC, Tanigawa M, Suarez A, Razavi S, DeRose R, Bobb D, Hong W, Gabelli SB, Goutsias J, Inoue T. 2017. Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nature Materials (In press, doi:10.1038/nmat5006)

Dharmaraj T and Wilson KL. (2017). How chromosomes unite. Nature 551:568-569.

Mulla WA, Seidel CW, Zhu J, Tsai HJ, Smith SE, Singh P, Bradford WD, McCroskey S, Nelliat AR, Conkright J, Peak A, Malanowski KE, Perera AG, Li R. 2017. Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast. Elife. 2017 Aug 25; 6. pii: e27991. doi: 10.7554/eLife.27991.

McDonald NALind ALSmith SELi RGould KL. 2017.  Nanoscale architecture of the Schizosaccharomyces pombe contractile ring. Elife. 2017 Sep 15; 6. pii: e28865. doi: 10.7554/eLife.28865.

Anderson KL, Page C, Swift MF, Suraneni P, Janssen MEW, Pollard TD, Li R, Volkmann N, Hanein D. 2017. Nano-scale actin-network characterization of fibroblast cells lacking functional Arp23 complex. Journal of structural biology, 197 (3) 312-321.

Scherer PC, Zaccor NW, Neumann NM, Vasavda C, Barrow R, Ewald AJ, Rao F, Sumner CJ, Snyder SH. 2017. TRPV1 is a physiological regulator of μ-opioid receptors. Proc Natl Acad Sci U S A. 2017 Dec 4. pii: 201717005. doi: 10.1073/pnas.1717005114. [Epub ahead of print]

Wu ZH, Plotnikov S, Moalim A, Waterman C, Liu J. 2017. Two distinct actin networks mediate traction oscillations to confer focal adhesion mechanosensing. Biophysical Journal 112(4): 780-94

Artemenko, Y., Devreotes, P. N. Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation. J. Vis. Exp.(129), e56411, doi:10.3791/56411 (2017).

Asrani K, Sood A, Torres A, Georgess D, Phatak P, Kaur H, Dubin A, Talbot CC Jr, Elhelu L, Ewald AJ, Xiao B, Worley P, Lotan TL. 2017. mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation. J Clin Invest. 2017 Nov 1;127(11):4001-4017. doi: 10.1172/JCI92893. Epub 2017 Sep 25.

Surcel A, Schiffhauer ES, Thomas D, Zhu Q, DiNapoli K, Herbig M, Otto O, Guck J, Jaffee E, Iglesias P, Anders R, Robinson DN. Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion. bioRxiv 190553; doi: https://doi.org/10.1101/190553. 2017

Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. Entosis is induced by glucose starvation. Cell Reports. 20(1): 201-210. 2017

Kameoka S, Adachi Y, Okamoto K, Iijima M, Sesaki H. 2017. Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics. Trends Cell Biol. [Epub ahead of print].

Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y. 2017. Excitable Signal Transduction Networks in Directed Cell Migration. Annu Rev Cell Dev Biol Oct. 6;33:103-125. Doi: 10.1146/annurev-cellbio-100616-060739. PMID: 28793794

Gerber S, Charif M, Chevrollier A, Chaumette T, Angebault C, Kane MS, Paris A, Alban J, Quiles M, Delettre C, Bonneau D, Procaccio V, Amati-Bonneau P, Reynier P, Leruez S, Calmon R, Boddaert N, Funalot B, Rio M, Bouccara D, Meunier I, Sesaki H, Kaplan J, Hamel CP, Rozet JM, Lenaers G. 2017. Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission. Brain. 140(10):2586-2596. 

McDonald NALind ALSmith SELi RGould KL. Nanoscale architecture of the Schizosaccharomyces pombecontractile ring. Elife. 2017 Sep 15; 6. pii: e28865. doi: 10.7554/eLife.28865.

Yochum ZA, Cades J, Mazzacurati L, Neumann NM, Khetarpal SK, Chatterjee S, Wang H, Attar MA, Huang EH, Chatley SN, Nugent K, Somasundaram A, Engh JA, Ewald AJ, Cho YJ, Rudin CM, Tran PT, Burns TF. 2017. A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer. Mol Cancer Res. 2017 Dec;15(12):1764-1776. doi: 10.1158/1541-7786.MCR-17-0298. Epub 2017 Aug 29.

Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN.  2017. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proc Natl Acad Sci USA Aug 28. Pii: 201616600. Doi: 10.1073/pnas.1616600114. [Epub ahead of print]. PMCID: PMC5603988

Nguyen-Ngoc KV, Silvestri VL, Georgess D, Fairchild AN, Ewald AJ. 2017. Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation. J Cell Sci. 2017 Oct 1;130(19):3213-3221. doi: 10.1242/jcs.208546. Epub 2017 Aug 18.

Greenspan LJ, Matunis EL. 2017. Live Imaging of the Drosophila Testis Stem Cell Niche. Methods Mol Biol. 1463:63-74.

Burr R, Stewart EV, Espenshade PJ. 2017. Coordinate regulation of yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 transcription factors. J. Biol. Chem. 292:5311-5324. PMCID: PMC5392677

Adachi Y, Itoh K, Iijima M, Sesaki H. 2017. Assay to measure interactions between purified Drp1 and synthetic liposomes. Bio-Protocol. Vol 7, Iss 9.

Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. 2017. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab. 25(3):647-660.

Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM. 2017. The putative Drp1 inhibitor mdivi-1 Is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species. Dev Cell. 2017;40(6):583-594.

Adachi Y, Iijima M, Sesaki H. An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid.  2017 Jun 23:1-8. doi: 10.1080/21541248.2017.1321614. [Epub ahead of print]

Florwick A, Dharmaraj T, Jurgens J, Valle D, Wilson KL. 2017.  LMNA sequences of 60,706 unrelated individuals reveal 132 novel missense variants in A-type lamins and suggest a link between variant p.G602S and Type 2 Diabetes.  Jun 15;8:79. doi: 10.3389/fgene.2017.00079. eCollection 2017.

Pereira R, Tadinada SM, Zasadny FM, Oliveira K, Pires KM, Olvera A, Jeffers J, Souvenir R, Mcglauflin R, Seei A, Funari T, Sesaki H, Potthoff MJ, Adams CM, Anderson EJ, Abel ED. 2017. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.  2017 Jun 12. pii: e201696179. doi: 10.15252/embj.201696179. [Epub ahead of print]

Cho B, Cho HM, Jo MY, Kim HD, Song M, Moon C, Kim H, Kim K, Sesaki H, Rhyu IJ, Kim H. Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division.  2017 Jun 9;8:15754. doi: 10.1038/ncomms15754.

Watanabe S. and Boucrot E. (2017) Fast and ultrafast endocytosis. Curr Opin Cell Biol. 5;47:64-71.

Topalidou I, Chen PA, Cooper K, Watanabe S, Jorgensen EM, Ailion M. (2017). The NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans. Genetics May;206(1):265-282.

Schiffhauer E, Robinson DN. 2017. Mechanochemical signaling directs cell shape change. Biophys. J. 112: 207-214. (Featured article)

Kothari P, Schiffhauer E, Robinson DN. Cytokinesis from nanometers to micrometers and microseconds to minutes. 2017. Methods Cell Biol. 137:307-322.

Yamada T, Adachi Y, Yanagawa T, Iijima M, Sesaki H. 2017. p62/sequestosome-1 knockout delays neurodegeneration induced by Drp1 loss. Neurochem Int. 2017 May 18. pii: S0197-0186(17)30189-4. doi: 10.1016/j.neuint.2017.05.012. [Epub ahead of print]

Rohani A, Moore JH, Kashatus JA, Sesaki H, Kashatus DF, Swami NS. Label-Free Quantification of Intracellular Mitochondrial Dynamics Using Dielectrophoresis. Anal Chem. 2017 Jun 6;89(11):5757-5764. doi: 10.1021/acs.analchem.6b04666. Epub 2017 May 15

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel M, Gabelli SB, Cole PA.  2017. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell 66 (3): 345-357. PMID: 28475870. DOI: 10.1016/j.molcel.2017.03.020

Xian L, Georgess D, Huso T, Cope L, Belton A, Chang YT, Kuang W, Zhang X, Senger S, Fassano A, Huso DL, Ewald AJ, Resar LMS. 2017. HMGA1 Amplifies Wnt Signaling and Expands the Intestinal Stem Cell Compartment and Paneth Cell Niche. Nat Communications, 2017 Apr 28;8:15008

Wells MB, Villamor J, and Andrew DJ. Salivary gland maturation and duct formation in the African malaria mosquito Anopheles gambiae. 2017. Scientific Reports 7:601. DOI: 10.1038/s41598-017-00672-0.

Rogers MA, Maldonado N, Hutcheson JD, Goettsch C, Goto S, Yamada I, Faits T, Sesaki H, Aikawa M, Aikawa E. 2017. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circ Res. 121(3):220-233.

Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias P, Devreotes PN. 2017.  Altering the threshold of an excitable signal transduction network changes cell migratory modes.  Nat Cell Biol 19:329-340.

Ruan L, Zhou C, Jin E, Kucharavy A, Zhang Y, Wen Z, Florens L, Li R. 2017. Cytosolic proteostasis through importing of misfolded proteins into mitochondriaNature; Mar 16; 543, 443–446; doi:10.1038/nature21695

Chung S, Kim S, and Andrew DJ. 2017. Uncoupling apical constriction from tissue invagination. Elife Mar6;6. pii: e22235. doi: 10.7554/eLife.22235. PMCID: PMC5338918

Yang J-M,  Schiapparelli P,  Nguyen H-N, Igarashi A, Zhang Q, Abbadi S, Amzel LM, Sesaki H, Quinones-Hinojosa A and Iijima M. 2017. Characterization of PTEN mutations in brain cancer reveals that PTEN mono-ubiquitination promotes protein stability and nuclear localization. Oncogene. Jun 29;36(26):3673-3685. doi: 10.1038/onc.2016.493. Epub 2017 Mar 6.

Ewald AJ. 2017. Pulling cells out of tumors. Nat Cell Biol. 2017 Mar 1;19(3):147-149. 

Nakamura H, Inoue T. 2017. Japanese Scientists in Science Signaling 2016. Science Signaling 2017 (In press)

Yang X, Wang H, Ni HM, Xiong A, Wang Z, Sesaki H, Ding WX, Yang L. 2017. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice. Redox Biol. 12:264-273

Salka K, Bhuvanendran S, Wilson K, Bozidis P, Mehta M, Rainey K, Sesaki H, Patterson GH, Jaiswal JK, Colberg-Poley AM. 2017. Superresolution imaging identifies that conventional trafficking pathways are not essential for endoplasmic reticulum to outer mitochondrial membrane protein Transport. Sci Rep. 7 (1):16.

Kwon D, Park E, Sesaki H, Kang SJ. Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission. 2017. Biochem Biophys Res Commun. 493(1):737-743

Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. 2017. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell 2017;168:264-279

Niu J., Johny M.B., Dick I.E., Inoue T. 2016. Following Optogenetic Dimerizers and Quantitative Prospects. Biophysical Journal 111:1132–1140

2016

Gaus K., Inoue T. 2016. New Biological Frontiers Illuminated by Molecular Sensors and Actuators. Biophysical journal. 2016; 111(6):E01-2.

Dorn J, Zhang L, Maddox P, Liu J, Maddox A. 2016. A theoretical model of cytokinesis implicates feedback between membrane curvature and cytoskeletal organization in asymmetric cytokinetic furrowing. Molecular Biology of the Cell 27(8): 1286-99

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. 2016. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 35:2332-2349. PMCID: PMC5090219

Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. 2016. Drp1 deficiency leads to Rip3-mediated necroptotic neurodegeneration. Am J Pathol. 186(11):2798-2802.

Ibo M, Srivastava V, Robinson DN, Gagnon Z. Cell blebbing in confined microfluidic environments. PLoS One 2016; 11(10): e0163866.

Lindberg OR, McKinney A, Engler JR, Koshkakaryan G, Gong H, Robinson AE, Ewald AJ, Huillard E, James CD, Molinaro AM, Shieh JT, Phillips JJ. 2016. GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. Oncotarget. 2016 Nov 29; 7(48):79101-79116

Artemenko Y, Axiotakis L Jr., Borleis J, Iglesias PA, Deveotes PN. 2016. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proc Natl Acad Sci USA. Nov. 22; 113(47):E7500-E7509. PMCID: PMC5127353 https://www.ncbi.nlm.nih.gov/pubmed/27821730

Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH. 2016. Protective Effects of Reduced Dynamin-related Protein 1 Against Amyloid Beta-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease. Hum Mol Genet. 25(23):5148-5166.

Gong X, Qian H, Shao W, Li J, Wu J, Li W, Espenshade PJ*, Nieng Y*. 2016. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 26:1197-1211. *Corresponding authors. PMCID: PMC5099872

Kandimalla R, Manczak M, Fry D, Suneetha Y, Sesaki H, Reddy PH. 2016. Reduced Dynamin-related Protein 1 Protects Against Phosphorylated Tau-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease. Hum Mol Genet. 25(22):4881-4897.

Teo WW, Merino V, Cho S, Korangath P, Liang X, Wu R, Neumann NM, Ewald AJ, Sukumar S. 2016.  HOXA5, a regulator of cell fate transition, impedes tumor initiation and progression in breast cancer. Oncogene. 2016 Oct 20; 35(42):5539-5551. 

Kojima R, Kajiura S, Sesaki H, Endo T, Tamura Y. 2016. Identification of multi-copy suppressors for ER-mitochondria tethering proteins in Saccharomyces cerevisiae. FEBS Lett. 2016; Epub ahead of print.

Yamada T, Adachi Y, Fukaya M, Iijima M, Sesaki H. Drp1 deficiency leads to Rip3-mediated necroptotic neurodegeneration. Am J Pathol. 2016; Epub ahead of print

Adachi Y, Itoh K, Yamada T, Cerveny KL, Suzuki TL, Macdonald P, Frohman MA, Ramachandran R, Iijima M, Sesaki H. Coincident phosphatidic acid interaction restrains Drp1 in mitochondrial division. Mol Cell. 2016;63:1034-43.

Shamir ER, Coutinho K, Auer M, Ewald AJ. 2016. Twist1+ epithelial cells retain adhesive and proliferative capacity during dissemination. Biol Open. 2016 Sep 15; 5 (9):1216-1228. 

Hanlon CD, Andrew DJ. Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. 2016. Dev Biol. 2016 Nov 15;419(2):273-284. doi: 10.1016/j.ydbio.2016.09.007. Epub 2016 Sep 13.

Potapova TA, Seidel CW, Box AC, Rancati G, Li R. 2016. Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. Mol Biol Cell. 2016 Oct 15;27(20):3065-3084. Epub 2016 Aug 24.

Watanabe S. 2016. Flash-and-freeze: coordinating optogenetic stimulation with rapid freezing to visualize membrane dynamics at synapses with millisecond resolution. Frontiers in Synaptic Neuroscience 8(24).

Wang PS, Chou FS, Ramachandran S, Xia S, Chen HY, Guo F, Suraneni P, Maher B,  Li R. 2016. Crucial Roles of the Arp2/3 Complex during Mammalian Corticogenesis.  Development 2016; Aug 1 143(15): 2741-2752

Loganathan R, Lee JS, Wells MB, Grevengood E, Slattery M, Andrew DJ. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol. 2016 Jan 1;409(1):234-50

Meier EL, Razavi S, Inoue T, Goley ED. A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in Caulobacter crescentus. Mol Microbiol. 2016 Jul;101(2):265-80.

Ast, T., Michaelis, S., Schuldiner, M.  (2016) The protease Ste24 clears clogged translocons.  Cell 164:103-114

Gaus K., Inoue T. 2016. New Biological Frontiers Illuminated by Molecular Sensors and Actuators. Biophysical Journal. 2016;111(6):E01–E02

Shao W, Machamer CE, Espenshade PJ. 2016. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res. 57:1564-1573.

Xiong ZM, Choi J, Wang K, Zhang H, Tariq Z, Wu D, Ko E, LaDana, C, Sesaki H, Cao K. Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell. 2016;15:279-290

Sonnenberg A and Wilson KL (2016). Preface. Methods Enzymol. 569:xix-xx. [Co-Editor]

Berk JM and Wilson KL. (2016). Simple separation of functionally distinct populations of lamin-binding proteins. Methods Enzymol. 569:101-114.

Maurer, M.J., Spear, E.D., Yu, A.T., Lee, E.J., Shahzad, S, and Michaelis, S.  (2016)  Degradation signals for ubiquitin-proteasome dependent cytosolic protein quality control (CytoQC) in yeast. G3:Genes, Genomes, Genetics 6:1853-66, PMC4938640.

Mehmood S., Marcoux J., Gault J., Quigley A., Michaelis S., Young S.G. Carpenter, E.P. and Robinson C.V. 2016. Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. Nature Chem. 8:1152-1158. PMC 512 3592

Zhang L, Trushin S, Christensen TA, Bachmeier BV, Gateno B, Schroeder A, Yao J, Itoh K, Sesaki H, Poon WW, Gylys KH, Patterson ER, Parisi JE, Diaz Brinton R, Salisbury JL, Trushina E. Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease. Sci Rep. 2016;6:18725

Senoo H, Cai H, Wang Y, Sesaki H, Iijima M. The novel racE binding protein GflB sharpens ras activity at the leading edge of migrating cells. Mol Biol Cell. 2016;27(10):1596-605.

Roy M, Itoh K, Iijima M, Sesaki H. Parkin suppresses Drp1-independent mitochondrial division. Biochem Biophys Res Commun. 2016;475(3):283-8.

Serbo JV, Kuo SC, Lewis S, Lehmann M, Li J, Gracias DH, Romer L.  Patterning of fibroblast and matrix anisotropy within three-dimensional confinement is driven by the cytoskeleton.  Adv Healthcare Mater 2016, 5:146-58

Khacho M, Clark A, Svoboda DS, Azzi J, MacLaurin JG, Meghaizel C, Sesaki H, Lagace DC, Germain M, Harper M-E, Park DS, Slack RS. 2016. Mitochondrial dynamics impact stem cell identity and fate decisions by regulating a nuclear transcriptional program. Cell Stem Cell. 19(2):232-47.

Coutinho K, Inoue T. 2016. Deconstructing and constructing innate immune functions using molecular sensors and actuators. Proc. SPIE 9871, Sensing and Analysis Technologies for Biomedical and Cognitive Applications 2016, 987102 (May 19, 2016); doi:10.1117/12.2225185 

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell. 2016;Epub ahead of print

Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang T-L, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA. Yes-Associated Protein impacts adherens junction assembly through regulating actin cytoskeleton organization. Am. J. Physiol. – Gastrointest. Liver Phys. 2016; In press.

Klionsky DJ et al. (~ 2000 authors). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1-222

Swaney KF, Li R. Function and regulation of the Arp2/3 complex during cell migration in diverse environments. Curr Opin Cell Biol. 2016 May 7;42:63-72.

Srivastava V, Iglesias PA, Robinson DN*. 2016. Cytokinesis: Robust cell shape regulation. Semin. Cell Dev. Biol. 2016; 53:39-44.

Yamada T, Adachi Y, Iijima M, Sesaki H. Making a division apparatus on mitochondria. Trends Biochem Sci. 2016;41:209-210

Senoo H, Sesaki H, Iijima M. A GPCR handles bacterial sensing in chemotaxis and phagocytosis. Dev Cell. 2016;36:354-356.

Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K, Berg-Alonso L, Kageyama Y, Serre V, Moore D, Verschueren A, Rouzier A, Le Ber I, Augé G, Cochaud C, Lespinasse F, N’Guyen K, Yu Wai Man P, Sesaki H, Pouget J, Paquis-Flucklingerm V. Reply: High prevalence of CHCHD10 mutations in patients with frontotemporal dementia from China. Brain. 2016;Epub ahead of print

Antonczak A.K., Mullee L., Wang Y., Comartin D., Inoue T., Pelletier L. and Morrison C.G. 2016. Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response.  30:2003-10. 

Cheung KJ, Ewald AJ, "A collective route to metastasis: Seeding by tumor cell clusters," Science. 2016 Apr 8;352(6282):167-9.

Burr R, Stewart EV, Shao W, Zhao S, Hannibal-Bach HK, Ejsing CS, Espenshade PJ. 2016. Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast. J Biol Chem. 2016 Jun 3;291(23):12171-83. doi: 10.1074/jbc.M116.723650. Epub 2016 Apr 6.

Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis E, Iglesias PA, Robinson DN*. Mechanoaccumulative elements of the mammalian actin cytoskeleton. Curr. Biol. 2016; 26: 1473-1479.

Ma Q, de Cuevas M, Matunis EL. Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary. Development. 2016 Mar 1;143(5):754-63. doi: 10.1242/dev.129627. 

Huebner RJ, Neumann NM, Ewald AJ, "Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration," 2016, Feb 2, Development.

Ellison D, Mugler A, Brennan M, Lee SH, Huebner RJ, Shamir ER, Woo LA, Kim J, Amar P, Nemenman I, Ewald AJ, Levchenko A, “Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis”, 2016, Jan 20, PNAS

Cheung KJ, Padmanaban VP, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Ewald AJ, “Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters,” 2016, Feb 1, PNAS.

Mackenzie ACL, Kyle DD, McGinnis LA, Lee HJ, Aidana N, Robinson DN, Evans JP. Cortical mechanics and myosin-II abnormalities associated with post-ovulatory aging:  Implications for functional defects in aged eggs. Mol. Hum. Reprod. 2016; 22(6):397-409.

Christianson MS, Gerolstein AL, Lee HJ, Monseur BC, Robinson DN, Evans JP. Effects of inhibition of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) on sperm incorporation and cortical tension in mouse eggs. Mol. Reprod. Dev. 2016; 83(3): 188-189.

Kim AK, DeRose R, Ueno T, Lin B, Komatsu T, Nakamura H, Inoue T. Toward total synthesis of cell function: Reconstituting cell dynamics with synthetic biology. Sci Signal. 2016 Feb 9;9(414). Review.

2015

P Vargas, P Maiuri, M Bretou, P Sáez, P Pierobon, M Maurin, M Chabaud, D Lankar, D Obino, E Terriac, M Raab, H R Thiam, HR2, T Brocker, S M Kitchen-Goosen, A Alberts, P Sunareni, S Xia, R Li , R Voituriez, M Piel, A M Lennon-Duménil. Innate Control of Actin Nucleation Determines Two Distinct Migration Behaviours In Dendritic Cells. Nat Cell Bio. doi: 10.1038/ncb3284. 2015 Dec 7. [Epub ahead of print]

Hu L, Vecchiarelli A, Mizuuchi K, Neuman K, Liu J. 2015. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system. PNAS 2015; 112(51): E7055-64.

Wells, M.B. and Andrew, D.J. (2015) Salivary gland cellular architecture in the Asian malaria vector mosquito Anopheles stephensi.  Parasites and Vectors. 8:617. doi: 10.1186/s13071-015-1229-z

Greenspan LJ, de Cuevas M, Matunis E. Genetics of gonadal stem cell renewal. Annu Rev Cell Dev Biol. 2015;31:291-315. doi: 10.1146/annurev-cellbio-100913-013344. 

Shao W, Espenshade PJ. 2015. Sugar Makes Fat by Talking to SCAP. Cancer Cell. 2015 Nov 9;28(5):548-9. doi: 10.1016/j.ccell.2015.10.011.

Cheng, Y.L. and Andrew, D.J. (2015) Extracellular Mipp1 activity confers migratory advantage to epithelial cells during collective migration. Cell Reports.  Published online November 25, 2015.

Watanabe, S. (2015). Slow or fast? A tale of synaptic vesicle recycling. Science, 350, 46-7.

Phua SC, Lin YC, Inoue T. An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli. Cell Calcium. 2015 Oct;58(4):415-22. Review.

Ewald AJ, "An arresting story about basement membrane invasion," Dev Cell. 2015 Oct 26;35(2):143-4

Kim M, Shewan A, Ewald AJ, Werb Z, Mostov KE, “P114RhoGEF governs cell motility and lumen formation during tubulogenesis via ROCK-myosin II pathway,” J Cell Sci. 2015 Oct 19.

Miyamoto T, Rho E, Inoue T. Deconvoluting AMPK dynamics. Oncotarget. 2015 Oct 13;6(31):30431-2.

Huang C-H and Devreotes PN. 2015. Reaction diffusion waves of phosphoinositides in the membrane. ASBMB TODAY September 2015, Lipid News.

Machamer, C.E. 2015. The Golgi complex in stress and death. Front. Neurosci. 9:421. PMCID: PMC4635215    

Westerbeck, J.W. and C.E. Machamer. 2015. A coronavirus E protein is present in two distinct pools with different effects on assembly and the secretory pathway. J. Virol. 2015 Sep;89(18):9313-23.

Hanlon, C.D. and Andrew, D.J. (2015) Outside-in signaling – a brief review of GPCR signaling with a focus on the Drosophila GPCR family. J Cell Sci 128: 3533-3542. PMID:  26345366.

Potapova TA, Unruh JR, Box AC, Bradford WD, Seidel CW, Slaughter BD, Sivagnanam S, Wu Y, Li RKaryotyping human and mouse cells using probes from single-sorted chromosomes and open source software. Biotechniques. 2015 Dec 1;59(6):335-46. doi: 10.2144/000114362. eCollection 2015.

Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G 3rd, Abedin M, Schurmans S, Inoue T, Reiter JF. Phosphoinositides regulate ciliary protein trafficking to modulate hedgedog signaling. Dev Cell. 2015 Aug 24;34(4):400-9.

Genin EC, Plutino M, Bannwarth S, Villa E, Cisneros-Barroso E, Roy M, Ortega-Vila B, Fragaki K, Lespinasse F, Pinero-Martos E, Augé G, Moore D, Burté F, Lacas-Gervais S, Kageyama Y, Itoh K, Yu-Wai-Man P, Sesaki H, Ricci JE, Vives-Bauza C, Paquis-Flucklinger V. CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis. EMBO Mol Med. 2015;8:58-72

Fox, R.M. and Andrew, D.J. (2015) Transcriptional regulation of secretory capacity by bZip transcription factors.  Front Biol 10: 28-51.  PMID:  25821458

Nguyen H-N, Yang J-M, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, and Iijima M. 2015. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.  Sci Rep Jul 28;5:12600. doi: 10.1038/srep12600. PMCID: PMC4517176.

Hasan, S., Hétié, P., and Matunis, E.L. (2015). Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1. Dev Biol 404, 27-39.

Santhanam B, Cai H, Devreotes PN, Shaulsky G, and Katoh-Kurasawa M. 2015. The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium.  Nat Commun. Jul6;6:7551. doi: 10.1038/ncomms8551. PMCID: PMC4506546.

Zhu J, Heinecke D, Mulla W, Bradford WD, Rubinstein B, Box A, Haug JS and Li R.  Single-cell based quantitative assay of chromosome transmission fidelity. G3. 2015;5:1043-56

Mohan K, Luo T, Robinson DN, Iglesias PA. Cell shape regulation through mechanosensory feedback control. J. R. Soc. Interface. In press.

Swaney K.F., Borleis J., Iglesias P.A., and Devreotes, P.N. 2015.  Novel protein Callipygian defines the back of migrating cells. PNAS 2015 Jun 30. pii:201509098. [Epub ahead of print]

Loganathan, R., Cheng, Y.L. and Andrew, D.J. (2015) ­Development of the Drosophila Respiratory System.  In:  Organogenetics.  Springer.  In press.

Mojica SA, Hovis KM, Frieman MB, Tran B, Hsia RC, Ravel J, Jenkins-Houk C, Wilson KL, Bavoil PM (2015) SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors. Molecular Biology of the Cell 26:1918-1934.

Raychaudhuri s, Espenshade PJ. 2015. Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity. J. Biol. Chem. 290:14430-40.

Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade PJ*, Nieng Y*. 2015. Crystal structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Research 25:401-11. PMCID: PMC4387560

Andrew, D.J. and Yelon, D. (2015) Developmental mechanisms, patterning and organogenesisis. Curr Opin Genet Dev. Epub 2015 Jun 4.

Hoeller O, Toettcher J, Cai H, Devreotes PN, and Weiner O.  Gβ tunes excitability of the actin cytoskeleton to support cell polarity.  PLOS Biology. In press.

Nguyen-Ngoc KV, Shamir ER, Huebner RJ, Beck JN, Cheung KJ, Ewald AJ, “3D Culture Assays of Murine Mammary Branching Morphogenesis and Epithelial Invasion,” Methods Mol Biol. 2015;1189:135-62.

Chen G, Mulla WA, Kucharavy A, Tsai HJ, Rubinstein B, Conkright J, McCroskey S, Bradford WD, Weems L, Haug JS, Seidel CW, Berman J, Li R. Targeting the Adaptability of Heterogeneous Aneuploids. Cell. 2015;160:771-784. 

Gao R, Zhao S, Sun Y, Sanjun Zhao, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, Pan T, Devreotes PN, Zhao M.  2015.  A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium Discoideum.  Sci Signal, May 26;8(378):ra50. Doi: 10.1126/scisignal.aab0562.  PMID: 26012633

Yang J-M, Nguyen H-N, Sesaki H, Devreotes PN, Iijima M. 2015. Engineering PTEN function: Membrane association and activity.  Methods. 2015 May; 0:119-124. PMCID: PMC4388803

Suraneni P, Fogelson B, Rubinstein B, Noguera P, Volkmann N, Hanein D, Mogilner A, Li R. A Mechanism of Leading Edge Protrusion in the absence of Arp2/3 Complex. Mol Biol Cell. 2015;26:901-12./p>

Shamir ER and Ewald AJ, “Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration,” Curr Top Dev Biol. 2015;112:353-82.

Roy, M., Reddy, P.H., Iijima, M., and Sesaki, H. (2015). Mitochondrial division and fusion in metabolism. Curr. Opin. Cell Biol. 33:111-118

Miyamoto T., Rho E, Sample V., Akano H., Magari M., Ueno T., Chen M., Tokumitsu H., Zhang J., and Inoue T.* “Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators” (Accepted at Cell Reports)

Lin B., Yin T., Wu Y.I., Inoue T.* and Levchenko A.* “Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration” (Accepted at Nature Communications)

McGinnis L, Lee H, Robinson DN, Evans JP. MAPK3/1 (ERK1/2) and myosin light chain kinase in mammalian eggs affect myosin-II function and regulate the metaphase II state in a calcium- and zinc-dependent manner. Biol. Reprod. 2015; In press.

Fox, R.M. and Andrew, D.J. (2015) Changes in organelle position and epithelial architecture associated with loss of CrebA.  Biology Open 4: 317-330.

Shields, L., Kim, H., Zhu, L., Haddad, D., Berthet, A., Pathak, D., Lam, M., Ponnusamy, R., Diaz-Ramirez, L., Gill, T., Sesaki, H., Mucke, L., and Nakamura, K. (2015). Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death Dis. Epub ahead of print. 

Roy M, Kageyama Y, Iijima M, and Sesaki H. PARK2/Parkin becomes critical when DNM1L/Drp1 is absent. Autophagy 2015 Feb. 25 [Epub ahead of print].

Serasinghe, M.N., Weider, S.Y., Renault, T.T., Elkholi, R., Asciolla, J.J., Yao, J.L., Jabado, O., Hoehn, K., Kageyama, Y., Sesaki, H., and Chipuk, J.E. (2015). Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors. Mol. Cell. 57: 521-536.

Li, S., Xu, S., Roelofs, B.A., Boyman, L., Lederer, J.W., Sesaki, H., and Karbowski, M. (2015). Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission. J. Cell Biol. 208: 109-123. 

Wang, L., Yu, T., Lee, H., O’Brien, D.K., Sesaki, H., and Yoon, Y. (2015). Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia. Cardiovasc. Res. 106: 272-283.

Kim JH, Ren Y, Ng WP, Li S, Son S, Kee Y-S, Zhang S, Zhang G, Fletcher DA, Robinson DN, Chen EH. Mechanical tension drives cell membrane fusion. Dev. Cell 2015; 561-573. 

Srivastava V, Robinson DN. Mechanical stress and network structure drive protein dynamics during cytokinesis. Curr. Biol. 2015; 25(5): 663-670. 

Surcel A, Ng W-P, West-Foyle H, Zhu Q, Ren Y, Avery L, Krenc AK, Meyers D, Rock RS, Anders RA, Freel Meyers C, Robinson DN*. Pharmacological activation of myosin II paralogs to correct cell mechanics defects. Proc. Natl. Acad. Sci. USA 2015; 112(5): 1428-1433. 

Luo T, Robinson DN. Kinetic Monte Carlo simulations of the assembly of filamentous biomacromolecules by the dimer addition mechanism. RSC Adv. 2015; 5: 3922-3929.

2014

Chapiro J, Sur S, Savic LJ, Ganapathy-Kniappan S, Reyes J, Duran R, Chettiar-Thiruganasambandam S, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, Geschwind JF, “Systemic delivery of microencapsulated 2-bromopyruvate for the therapy of pancreatic cancer, Clinical Cancer Research 2014 Dec 15;20(24):6406-17.

Zhou C, Slaughter BD, Unruh JR, Guo F, Yu Z, Mickey K, Narkar A, Ross RT, McClain M, Li R. Organelle-based aggregation and retention of damaged proteins in asymmetrically dividing cells. Cell. 2014;159:530-542.

Tong Z, Kim MS, Pandey A, Espenshade PJ. 2014. Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast. Mol. Cell Proteomics 13:2871-82. PMCID: PMC4223478

Chen J, Liu J. 2014. Spatial-temporal model for silencing of the mitotic spindle assembly checkpoint. Nature Communications 5(9): 4795.

Stine, R.R., Greenspan, L.J., Ramachandran, K.V., and Matunis, E.L. (2014). Coordinate regulation of stem cell competition by Slit-Robo and JAK-STAT signaling in the Drosophila testis. PLoS Genet 10, e1004713.

Wang M, Artemenko Y, Cai W, Iglesias PA and Peter N. Devreotes. (2014). The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient.  Cell Rep Nov 6;9(3):1110-21. doi: 10.1016/j.celrep.2014.09.047. Epub 2014 Oct 23. PMID: 25437564 [PubMed – in process]. PMCID:PMC4250826

Ma, Q., Wawersik, M., Matunis, EL.  2014.  The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche. Dev Cell 31, 474-486.

Kageyama, Y., Hoshijima, M., Seo, K., Bedja, D., Sysa-Shah, P., Andrabi, S., Chen, W., Höke, A., Dawson, V.L., Dawson, T.M., Gabrielson, K., Kass, D.A., Iijima, M., and Sesaki, H. (2014). Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. EMBO J. 33: 2798-2813.

Cheung KJ and Ewald AJ, “Illuminating breast cancer invasion: diverse roles for cell-cell interactions”, Current Opinion in Cell Biology, 2014, Oct; 30:99-111.

Bryant DM, Roignot J, Datta A, Orvereem A, Kim M, Yu W, Peng X, Eastburn D, Ewald AJ, Werb Z, and Mostov K, “A molecular switch for the orientation of epithelial cell polarization,” Dev Cell, 2014 Oct 27;31(2):171-87.

Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, and Huang CH  (2014).  Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nat Commun. Oct 27;5:5175. PMCID: PMC4211273 [Available on 2015/4/27)]

Yang JM, Nguyen HN, Sesaki H, Devreotes PN, and Iijima M. 2014.  Engineering PTEN function: Membrane association and activity.  Methods Oct 22. pii: S1046-2023(14)00335-1. doi: 10.1016/j.ymeth.2014.10.018. [Epub ahead of print]. PMID: 25448479

Kageyama, Y., Hoshijima, M., Seo, K., Bedja, D., Sysa-Shah, P., Andrabi, S., Chen, W., Höke, A., Dawson, V.L., Dawson, T.M., Gabrielson, K., Kass, D.A., Iijima, M., and Sesaki, H. (2014). Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. EMBO J. 33: 2798-2813.

Shamir ER and Ewald AJ, “3D Organotypic Culture: Experimental Models of Mammalian Biology and Disease,” Nature Reviews Molecular Cell Biology, 2014 Oct;15(10):647-64.

Ren Y, West-Foyle H, Surcel A, Miller C, Robinson DN. Genetic suppression of a phosphomimic myosin II identifies system-level factors promoting myosin II cleavage furrow accumulation. Mol. Biol. Cell. 2014; 25: 4150-4165.

Berthet, A., Margolis, E.B., Zhang, J., Hsieh, I., Zhang, J., Hnasko, T.S., Ahmad, J., Edwards, R.H., Sesaki, H., Huang, E.J., and Nakamura K. (2014). Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J. Neurosci. 34: 14304-14317.

Bannwarth, S., Ait-El-Mkadem, S., Chaussenot, A., Genin, E.C., Lacas-Gervais, S., Fragaki, K., Berg-Alonso, L., Kageyama, Y., Serre, V., Moore, D., Verschueren, A., Rouzier, A., Le Ber, I., Augé, G., Cochaud, C., Lespinasse, F., N’Guyen, K., Yu Wai Man, P., Sesaki, H., Pouget, J., Paquis-Flucklingerm V. (2014). A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain. 137: 2329-2345.

Guo, X., Sesaki, H., and Qi, X. (2014). Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions, in vitro and in vivo. Biochem. J. 461: 137-146.

Watanabe, S., M.W. Davis, and E.M. Jorgensen. 2014. Flash-and-freeze electron microscopy: coupling optogenetics with high-pressure freezing. In Imaging nanoscale dynamics at synapses. Ed. V. Nägerl and A. Triller. Springer Verlag. Neuromethods 84, p43-57. Book chapter.

Watanabe, S., T. Trimbuch, M. Camacho-Pérez, B.R. Rost, B. Brokowski, B. Söhl-Kielczynski, A. Felies, M.W. Davis, C. Rosenmund, and E.M. Jorgensen. 2014. Clathrin regenerates synaptic vesicles from edosomes. Nature 515, p228-33,  DOI 10.1038/nature13846. PMCID: PMC4291189.

Li, Y., Ma, Q., Cherry, C.M., and Matunis, E.L. (2014). Steroid signaling promotes stem cell maintenance in the Drosophila testis. Dev Biol 394, 129-141.

Fox, R.M. and Andrew, D.J. (2014) Transcriptional regulation of secretory capacity by bZip transcripton factors.  Frontiers in Biology 10.1007/s11515-014-1338-7 DOI

Berk JM, Simon DN, Jenkins-Houk CR, Westerbeck JW, Gronning-Wang LM, Carlson CR, Wilson KL (2014) The molecular basis of emerin-emerin and emerin-BAF interactions. J. Cell Science 127:3956-3969. 

Macdonald, P.J., Stepanyants, N., Mehrotra, N., Mears, J.A., Qi, X., Sesaki, H., and Ramachandran, R. (2014). A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol. Biol. Cell. 25: 1905-1915.

Watanabe,  S., M. Lehmann, E. Hujber, R.D. Fetter, J. Richards, B. Söhl-Kielczynski, A. Felies, C. Rosenmund, J. Schmoranzer, and E.M. Jorgensen.  2014. Nanometer-resolution fluorescence electron microscopy (nano-fEM) in cultured cells. Ed. J. Kuo. Humana Press. In Methods in Molecular Biology: Electron Microscopy  1117, p. Book chapter.

Nguyen, H-N., Yang, J.M., Rahdar, M., Keniry, M., Swaney KF, Parsons, R., Park, B.H., Sesaki, H., Devreotes, P.N. and Iijima, M. 2014.  A new class of cancer-associated PTEN mutations defined by membrane translocation defects.  Oncogene Sept 29;0. Doi: 10.1038/onc.2014.293. [Epub ahead of print].  PMID: 25263454

Artemenko, Y., Lampert, T.J., Devreotes, P.N. 2014. Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci. Oct;71(19):3711-47. doi: 10.1007/s00018-014-1638-8. Epub 2014 May 21. PMCID: PMC4162842  [Available on 2015/10/1]

Sun Q, Luo T, Ren Y, Shirasawa S, Sasazuki T, Cibas ES, Hodgson L, Robinson DN, Overholtzer M. Competition between human cells by entosis. Cell Res. 2014; 24: 1299-1310.

Ewald AJ and Egeblad M, “Sugar Coated Cell Signaling”, Nature. 2014 Jul 17;511(7509):298-9.

Huebner RJ and Ewald AJ, “Cellular Foundations of Mammary Tubulogenesis,” Semin Cell Dev Biol. 2014 Jul;31:124-31.

Onuma H, Komatsu T, Arita M, Hanaoka K, Ueno T, Terai T, Nagano T, Inoue T.  2014.  Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation.  Sci Signal.  Jul 15;7(334):rs4. doi: 10.1126/scisignal.2005123.

Damarla, M., Parniari, A.R., Johnston, L., Maredia, H. Serebreni, L., Hamdan, O., Sidhaye, V.K., Shimoda, L.A., Myers, A.C., Crow, M.T., Schmidt, E.P., Machamer, C.E., Gaestei, M. Rane, M.J., Kolb, T.M., Kim, B.S., Damico, R.L., and Hassoun, P.M. (2014) MK2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am. J. Respir. Cell Mol. Biol. 50:932-41.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, and Leslie NR. (2014) A unified nomenclature and amino acid numbering for human PTEN. Sci Signal July 1;7(332):pe15. PMID 24985344 [PubMed – as supplied by publisher]

Nguyen HN, Yang JM, Afkari Y, Park BH, Sesaki HDevreotes PN, and Iijima M.  2014.  Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. Proc Natl Acad Sci U S A. Jul 1;111(26):E2684-93. PMID: 24979808

Devreotes, P.N. and Horwitz, A.R. Signaling networks that regulate cell migration. In: Cantley, L.C., Hunter, T., Sever, R., Thorner, J. (Eds). 2014.  Signal Transduction.  Principles, Pathways and Processes. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York: pp. 183-198.

Chung, S.-Y. and Andrew, D.J. (2014)  Building and specializing epithelial tubular organs:  the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.  Wiley Interdiscip Rev Dev Biol. 3:281-300. PMID: 25208491 

Tamura, Y., Sesaki, H., and Endo, T. (2014). Phospholipid transfer via mitochondria. Traffic. 15: 933-945.

Chung, S.-Y. and Andrew, D.J. (2014) Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation. Development 141:1950-1960. PMID: 24718992

Suarez A., Ueno T., Huebner R., McCaffery J.M., and Inoue T.* “Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells” Scientific Reports 4, 4693 (2014)

Zhang, Q., Tamura, Y., Roy, M., Adachi, Y., and Iijima, M., and Sesaki, H. (2014). Biogenesis and roles of phospholipids in mitochondrial fusion, division and mitophagy. Cell Mol. Life Sci. 71: 3767-3778.

Hetie, P., de Cuevas, M. and Matunis, E.  2014.  Conversion of Quiescent Niche Cells to Somatic Stem Cells Causes Ectopic Niche Formation in the Drosophila Testis. Cell Reports 7, 715-721.

Sesaki, H., Adachi, Y., Kageyama, Y., Itoh, K., and Iijima, M. (2014). In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta. 1842: 1179-1185.

Luo T, Srivastava V, Ren Y, Robinson DN. Mimicking the mechanical properties of the cell cortex by the self-assembly of an actin cortex in vesicles. App. Phys. Lett. 2014; 104: 153701-1-5.

Gilbert, C.E., D.M. Zuckerman, P.L. Currier, and C. E. Machamer. 2014. Three basic residues of intracellular loop 3 of the beta-1 adrenergic receptor are required for golgin-160-dependent trafficking. Int. J. Mol. Sci.15:2929-45.  

Mulla W, Zhu J, Li R. Yeast: a simple model system to study complex phenomena of aneuploidy. FEMS Microbiol Rev. 2014 Mar;38(2):201-12. doi: 10.1111/1574-6976.12048. Epub 2013 Oct 31. Review. PMID:24118136.

Cheung KJ and Ewald AJ, “Invasive leader cells: metastatic oncotarget,” Oncotarget. 2014 Mar 30;5(6):1390-1.

Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, and Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science. 2014 Mar 21;343(6177):1249531. doi: 10.1126/science.1249531.

Shao W, Espenshade PJ. 2014. Sterol Regulatory Element-binding Protein (SREBP) cleavage regulates Golgi-to-Endoplasmic Reticulum recycling of SREBP Cleavage-activating Protein (SCAP). J. Biol. Chem. 289:7547-7557.

Guo X., Sesaki H., and Qi X. (2014). Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions, in vitro and in vivo. Biochem. J. 461: 137-146.

Brookheart RT, Lee CY, Espenshade PJ. 2014. Casein kinase 1 regulates sterol regulatory element- binding protein (SREBP) to control sterol homeostasis. J. Biol. Chem. 289:2725-2735.

Huebner RJ, Lechler T, Ewald AJ, “Mammary epithelial stratification occurs through symmetry breaking vertical divisions of luminal cells,” Development. 2014 Mar;141(5):1085-94

Shamir ER, Papallardo E, Jorgens DM, Coutinho K, Tsai WT, Aziz K, Auer M, Tran PT, Bader JS, Ewald AJ, “Twist1-induced dissemination preserves epithelial identity and requires E-cadherin,” JCB 2014 Mar 3;204(5):839-56 (Selected for cover). 

Huebner RJ, Lechler T, Ewald AJ, “Mammary epithelial stratification occurs through symmetry breaking vertical divisions of luminal cells,” Development. 2014 Mar;141(5):1085-94. 

Yang, Z., Grinchuk, V., Smith, A., Qin, B., Bohl, J., Sun, R., Notari, L., Zhang, Z., Sesaki, H., Urban, J., Shea-Donohue, T., and Zhao, A. (2014). Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infection and Immunity. 81: 1905-1914

Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, and Pan DJ, “A temporal requirement for Hippo signaling in mammary gland differentiation, growth and tumorigenesis”, Genes Dev. 2014 Mar 1;28(5):432-7.

Senoo, H. and Iijima, M. Rho GTPase: a molecular compass for directional cell migration. Commun. Integr. Biol. (2014). Epub ahead of print

Clerc, P., Ge, S.X., Hwang, H., Waddell, J., Roelofs, B.A., Karbowski, M., Sesaki, H., and Polster, B.M. (2014). Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes. Br. J. Pharmacol. 171: 1988-1999

Adachi, Y. and Sesaki, H. (2014). Cyclin C: An inducer of mitochondrial division hidden in the nucleus. Developmental Cell. 28: 112-114

Kobayashi T., Kim S., Lin Y.C., Inoue T., and Dynlacht B.D. “CP110-interacting proteins, Talpid3 and Cep290, play overlapping and distinct roles in cilia assembly.” Journal of Cell Biology 204, 215 (2014) 

Richter, V., Palmer, C.S., Osellame, J.D., Singh, A. P., Elgass, K., Stroud, D.A., Sesaki, H., Kvansakul, M., and Ryan, M.T. (2014). Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. J. Cell Biol. 204: 477-486.

Adachi, Y. and Sesaki, H., (2014). Cyclin C: Mitochondrial division inducer hidden in the nucleus. Developmental Cell. 28: 112-114

2013

Cheung KJ, Gabrielson, E, Werb Z, Ewald AJ, “Collective invasion in breast cancer requires a conserved basal epithelial program,” Cell, 2013 Dec;155(7):1639-51.

Beck JN, Singh A, Rothenberg AR, Elisseeff JH, Ewald AJ, The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination, Biomaterials, 2013 Dec;34(37):9486-95.  

Cockburn IA, Amino R, Kelemen RK, Kuo SC, Tse SW, Radke A, Mac-Daniel L, Ganusov VV, Zavala R, Menard R.  In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages.  Proc Natl Acad Sci 2013, 110:9090-5

Smith SE, Rubinstein B, Mendes Pinto I, Slaughter BD, Unruh JR, Li R. Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42.  J Cell Biol. 2013;202:1091-1106.

Nguyen, H-N., Afkari, Y., Senoo, H., Sesaki, H., Devreotes, P.N. and Iijima, M. (2013). Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene, Dec. 2. Doi: 10.1038/onc.2013.507. [Epub ahead of print]. PMID:24292679. PMCID: PMC4041858 [Available on 2015/6/2]

Su S., Phua S.C., DeRose R., Chiba S., Narita K., Kalugin P.N., Katada T., Kontani K., Takeda S. and Inoue T. “Genetically encoded calcium indicator illuminates calcium dynamics in cilia.” Nature Methods 10, 1105 (2013)

Huang, C.,Tang, M., Shi, C., Iglesias, P., and Devreotes, P.N. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol. 2013 Nov;15(11):1307-16.

Gu, M., Q. Liu, S. Watanabe, L. Sun, B. Grant, and E.M. Jorgensen. 2013. AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis. eLife 2, p00190.  PMCID: PMC3591783.

Watanabe, S., Q. Liu, M.W. Davis , N. Thomas, J. Richards, G. Hollopeter, M. Gu, N.B. Jorgensen and E.M. Jorgensen. 2013. Ultrafast endocytosis at the C. elegans neuromuscular junction.  eLife  2:e00723.  PMCID: PMC3762212.

Li R. The art of choreographing asymmetric cell division. Dev Cell. 2013;25:439-450.

Stine RR, Matunis EL.  2013.  JAK-STAT signaling in stem cells. Adv. Exp. Med. Biol. 786: 247-67.  PMID: 23696361.

Abrams, E.W., Cheng, Y.L. and Andrew, D.J. (2013) Drosophila KDEL receptor function in the embryonic salivary gland and epidermis. PLoS One. 2013 Oct 18;8(10):e77618. doi: 10.1371/journal.pone.0077618. eCollection 2013. PMID: 24204897

Thevathasan, J.V., Tan E., Hui Z., Lin Y.C., Li Y., Inoue T. and Fivaz M. “The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts.” Molecular Biology of the Cell 24, 2228 (2013)

Lin Y.C., Niewiadomski P., Lin B., Nakamura H., Phua S.C., Jiao J., Levchenko A., Inoue T., Rohatgi T., and Inoue T. “Chemically-inducible diffusion trap reveals molecular sieve-like barrier at primary cilia“ Nature Chemical Biology 9, 437 (2013)

Yi K, Rubinstein B, Unruh JR, Guo F, Slaughter BD, Li R. Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. J Cell Biol. 2013;200:567-576. 

Kane, M. S., Linsday, M. E., Judge, D. P., Barrowman, J., Ap Rys, C., Simonson, L., Dietz, H.C., Michaelis, S. (2013) LMNA-associated cardiocutaneous progeria: an inherited autosomal dominant premature aging syndrome with late onset. American Journal of Medical Genetics A 161:1599-1611 PMCID: PMC3740161

Kabacoff C, Srivastava V, Robinson DN. A Summer Academic Research Experience for Disadvantaged Youth. CBE Life Sci. Educ. 2013; 12:410-418.

Shao, Z., Watanabe, S., Christensen, R., Jorgensen, E.M., and Colón-Ramos, D.A., (2013). Synapse location during growth depends on glia location, Cell 154, 337-350. PMCID: PMC3808971.

Nguyen-Ngoc KV and Ewald AJ, “Mammary epithelial elongation and myoepithelial migration are regulated by the composition of the extracellular matrix,” J Microsc. 2013 Sep;251(3):212-23.

Lin YC, Liu T-Y, Razavi S. and Inoue T. “Rapidly Reversible Manipulation of Molecular Activities Using Dual Chemical Dimerizers” Angewandte Chemie 52, 6450 (2013)

Watanabe, S., B. Rost., M. Camacho, M. W. Davis, B. Söhl-Kielczynski, A. Felies, C. Rosenmund and E.M. Jorgensen. 2013. Ultrafast endocytosis at mouse hippocampal synapses.  Nature. 504, 242-7.  doi: 10.1038/12809. PMCID: PMC3957339.

Li R, Albertini DF. The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte. Nat Rev Mol Cell Biol.2013;14:141-152.

Snider J., Hanif A., Lee M. E., Jin K., Yu A. R., Graham C., Chuk M., Damjanovic D., Wierzbicka M., Tang P., Balderes D., Wong V., Jessulat, M., Darowski, K.D. San Luis, BJ., Shevelev, I. Sturley S. L., Boone C., Greenblatt J. F., Zhang Z., Paumi C. M., Babu M., Park H.-O., Michaelis S., and I. Stagljar. (2013) Mapping the functional yeast ABC interactome. Nature Chem. Biol. 9:565-72 PMID: 23831759

Taylor, M.S., T.R. Ruch, P.Y. Hsiao, Y. Hwang, P. Zhang, L. Dai, C.R. Huang, C.E. Berndsen, M.S. Kim, A. Pandey, C. Wolberger, R. Marmorstein, C. Machamer, J.D. Boeke, and P.A. Cole. 2013. Architectural organization of the metabolic regulatory enzyme ghrelin-O-acyltransferease. J. Biol. Chem.288:32212-28. PMCID: PMC3820860.

Stine RR, Matunis EL.  Stem cell competition: finding balance in the niche.  2013 Aug;23(8):357-64.

Roppenser, B., Kwon, H., York, J.D., Snyder, S.H., Devreotes, P. N., Grinstein, S., and Brummel, J.H. 2013. Multiple host kinases contribute to Akt activation during Salmonella infection. PLoS One. 2013 Aug 22;8(8):e71015.

Bar DZ, Davidovich M, Lamm AT, Zer H, Wilson KL and Gruenbaum Y (2014) BAF-1 mobility is regulated by environmental stresses. Molecular Biology of the Cell 25:1127-36. PMC3967975

Slaughter BD, Unruh JR, Das A, Smith SE, Rubinstein B, Li R. Non-uniform membrane diffusion enables steady-state cell polarization via vesicular trafficking. Nat Commun. 2013;4:1380.

Shi, C., Huang, C., Devreotes, P.N., and Iglesias, P.  2013. Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLOS Computational Biol. 2013 Jul;9(7):e1003122. 

Michaelis, S. and Hrycyna, C.A. (2013) A protease for the ages. Science 339:1529-30. PMID: 23539586

Kee YS, Robinson DN. Micropipette Aspiration for Studying Cellular Mechanosensory Responses and Mechanics. Methods Mol. Biol. 2013; 983:367-382.

Bolduc, D.M., Rahdar, M., Tu-Sekine, B., Sivakumaren S.C., Raben, D.M., Amzel, L.M., Devreotes, P.N.,   Gabelli, S.B., Cole, P.A.  Phosphorylation-mediated PTEN Conformational Closure and Deactivation Revealed with Protein Semisynthesis. Elife. 2013 Jul 9;2:e00691

Itoh, K., Tamura, Y., Iijima, M., and Sesaki H. (2013). Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology. Mol. Biol. Cell. 24: 1842-1851

Sesaki, H., Adachi, Y., Kageyama, Y., Itoh, K., and Iijima, M. (2013). In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta. Epub ahead of print.

Srivastava V, Robinson DN. Cytokinesis. In Lennarz & Lane (eds.) The Encyclopedia of Biological Chemistry, 2013; Waltham, MA: Academic Press. Vol. 3, pp. 622-626.

Barrowman, J., and Michaelis, S. (2013) The Ste24p Protease. In “Handbook of Proteolytic Enzymes,3nd Edition” (N. Rawlings, and G. S. Salvesen, eds.) Academic Press, Oxford, pp.668-676

Berk JM, Maitra S, Dawdy AW, Shabanowitz J, Hunt DJ and Wilson KL. (2013) O-GlcNAc regulates emerin binding to BAF in a chromatin- and lamin B-enriched ‘niche’. J. Biological Chemistry 288:30192-209.

Berk JM, Tifft KE and Wilson KL. (2013) The nuclear envelope LEM-domain protein emerin. Nucleus 4:1-17. 

Clerc, P., Ge, S.X., Hwang, H., Waddell, J., Roelofs, B.A., Karbowski, M., Sesaki, H., and Polster, B.M. (2013). Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes. Br. J. Pharmacol. Epub ahead of print.

Wozniak M, Baker BM, Chen C and Wilson KL. (2013) Emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions. PeerJ e134

Simon DN and Wilson KL. (2013) Partners and posttranslational modifications of nuclear lamins. Chromosoma 122:13-31. 

Kryzak CA, Moraine MM, Kyle DD, Lee HJ, Robinson DN, Evans JP. Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy. Biol. Reprod. 2013; 89: 44, 1-13.

Yang, Z., Grinchuk, V., Smith, A., Qin, B., Bohl, J., Sun, R., Notari, L., Zhang, Z., Sesaki, H., Urban, J., Shea-Donohue, T., and Zhao, A. (2013). Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infection and Immunity. 81: 1905-1914

Fox, R.M., Vaishnavi, A., Maruyama, R., and Andrew, D.J. (2013) Organ-specific gene expression: the bHLH protein Sage provides tissue-specificity to Drosophila FoxA. Development. 140 (10): 2160-2171. PMID: 23578928. 

Barbosa S, Fasanella G, Carreira S, Llarena M, Fox R, Barreca C, Andrew D, O'Hare P. 2013 An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H. Traffic. 2013 Apr;14(4):382-98. doi: 10.1111/tra.12038.

Sbodio, J.I., B.D. Paul, C.E. Machamer, and S.H. Snyder. 2013. Golgi protein ACBD3 mediates neurotoxicity associated with Huntington’s disease. Cell Reports 4:890-897. PMCID: PMC3801179

Luo T, Mohan K, Iglesias PA, Robinson DN. Molecular mechanisms of cellular mechanosensing. Nat. Mater. 2013; 12: 1064-1071.

Itoh, K., Nakamura, K., Iijima, M., and Sesaki, H. (2013). Mitochondrial dynamics in neurodegeneration. Trends Cell Biol. 23: 64-71

Zhao S, Gao R, Devreotes PN, Mogilner A, Zhao M. 3D Arrays for high throughput assay of cell migration and electrotaxis. Cell Biol Int. 2013 Apr 16. 

Lloyd SJ, Raychaudhuri S, Espenshade PJ. 2013. Subunit architecture of the Golgi Dsc E3 ligase required for Sterol Regulatory Element-Binding Protein (SREBP) cleavage in fission yeast. J. Biol. Chem. 288:21043-54.

Michaelis, S. and Hrycyna, C.A. (2013) A protease for the ages. Science 339:1529-30

Ismat, A., Cheshire, A. and Andrew, D.J. (2013) The secreted AdamTS-A metalloprotease is required for collective cell migration. Development. 140 (9): 1981-93. doi: 10.1242/dev.087908. Epub 2013 Mar 27. PMID: 23536567.

Kane, M. S., Lindsay, M. E., Judge, D. P., Barrowman, J., Ap Rys, C., Simonson, L., Dietz, H.C., Michaelis, S. (2013) LMNA-associated cardiocutaneous progeria: an inherited autosomal dominant premature aging syndrome with late onset. American Journal of Medical Genetics, Part A (In Press).

Cheung R, Espenshade PJ. 2013. Structural requirements for Sterol Regulatory Element- Binding Protein (SREBP) cleavage in fission yeast. J. Biol. Chem. 288:20351-60.

Machamer, C.E. 2013. Accommodation of large cargo within Golgi cisternae. Histochem. Cell Biol., 140:261-269.

Simon DN, Domaradzki T, Hofmann WA and Wilson KL. (2013) Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations. Molecular Biology of the Cell 24:342-50.

Thevathasan, J.V., Tan E., Hui Z., Lin Y.C., Li Y., Inoue T. and Fivaz M. “Local positive feedback from PI3K to Ras drives cell polarization and migration” Molecular Biology of the Cell (doi:10.1091/mbc.E12-12-0905)

Barbosa S, Fasanella G, Carreira S, Llarena M, Fox R, Barreca C, Andrew D, and O'Hare P. (2013) An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcripton factor CREB-H. Traffic. 14: 382-398.

Artemenko Y and Devreotes PN.  2013.  Hippo on the move: tumor suppressor regulates adhesion and migration. Cell Cycle Feb 15;12(4):535-6. doi: 10.4161/cc.23668. Epub 2013 Jan 31. PMCID: PMC3594247

Espenshade PJ. 2013. Cholesterol Synthesis and Regulation. In: Lennarz, W.J. and Lane, M.D. (eds.) The Encyclopedia of Biological Chemistry, Vol. 3, pp. 516-520. Waltham, MA: Academic Press.

Tamura, Y., Harada, Y., Nishikawa, S., Yamano, K., Megumi, K., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K., and Endo, T. (2013). Tam41 is a novel CDP-diacylglycerol synthase for cardiolipin biosynthesis in mitochondria. Cell Metabolism. 17: 709-18.

Wang, Y., Senoo, H., Sesaki, H. and Iijima, M. Rho GTPases orient gradient sensing in chemotaxis. Proc. Natl. Acad. Sci. USA. (2013). 110: E4723-32.

Hung, W., Chen, S, Paul, C.D., Stroka, K.M., Lo, Y., *Yang, J. T.  and *Konstantopoulos, K. (*co-corresponding authors).  (2013).  Distinct signaling mechanisms regulate migration in unconfined and confined spaces.  J. Cell Biol. 202, 807-824.

2012

Pinto IM, Rubinstein B, Kucharavy A, Unruh J, Li R. Actin Depolymerization Drives Actomyosin Ring Contraction during Budding Yeast Cytokinesis. Dev Cell. 2012;22:1247-1260.

Matunis EL, Stine RR, de Cuevas M.  2012.  Recent advances in Drosophila male germline stem cell biology.  Spermatogenesis 2: 137-144.  PMID: 23087833.

Sinden D, Badgett M, Fry J, Jones T, Palmen R, Sheng X, Simmons A, Matunis E, Wawersik M.  2012.  Jak-STAT regulation of cyst stem cell development in the Drosophila testis.  Dev. Biol. 372: 5-16.  PMID: 23010510.

Chen G, Bradford WD, Seidel CW, Li R. Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature. 2012;482:246-250.

Issigonis M, Matunis E.  2012.  The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche.  Dev. Biol. 368: 181-92.  PMID: 22580161.

Das A, Slaughter BD, Unruh JR, Bradford WD, Alexander R, Rubinstein B, Li R. Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity. Nat Cell Biol. 2012;14:304-310.

Watanabe, S., Richards, J., Hollopeter, G., Hobson, R.J., Davis, M.W., and Jorgensen, E.M. 2012. Nano-fEM: protein localization using correlative photo-activated localization microscopy and electron microscopy. Journal of Visual Experiments 3, e3995. doi: 10.3791/3995. PMCID: PMC3566706

Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ, “The ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium” Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2595-604. PMC3465416.  

Suraneni P, Rubinstein B, Unruh JR, Durnin M, Hanein D, Li R. The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration. J Cell Biol. 2012;197:239-251.

Zhu J, Pavelka N, Bradford WD, Rancati G, Li R. Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast. PLoS Genet. 2012;8:e1002719.

Kageyama, Y., Zhang, Z., Roda, R., Fukaya, M., Wakabayashi, J., Wakabayashi, N., Kensler, T.W., Reddy, P.H., Iijima, M. and Sesaki, H. (2012). Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J. Cell Biol. 197(4):535-51.

Zhang, Z., Kageyama, Y., and Sesaki, H. (2012). Mitochondrial division prevents neurodegeneration. Autophagy. 8: 1531-1533

Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M, "Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium", J Cell Sci. 2012 Jun 1;125(Pt 11):2638-54. PMC3403234.

Tamura, Y., Onguka, O., Itoh, K., Endo, T., Iijima, M., Claypool, S.M., and Sesaki, H. (2012). Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins, Ups1p and Ups2p.  J. Biol. Chem. 287:43961-43971

Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sanséau, D., Willard, S.S., Schleicher, M., and Devreotes, P.N.  2012. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion.  PNAS 2012;109(34):13632-13637.

Tamura, Y., Onguka, O., Aiken Hobbs, A.E., Jensen, R.E., Iijima, M., Claypool, S.M., and Sesaki, H. (2012). Role for two conserved intermembrane space proteins, Ups1p and Up2p, in intra-mitochondrial phospholipid trafficking. J. Biol. Chem. 287(19):15205-15218.

Robinson DN, Iglesias PA. Bringing the physical sciences into your cell biology research. Mol. Biol. Cell 2012; 23(21): 4167-4170.

Michaelis, S. and Barrowman, J. Biogenesis of the Saccharomyces cerevisiae pheromome a-factor; from yeast mating to human disease. (2012) Microbiology and Molecular Biology Reviews 76: 626-651.

Chandran, S. and C.E. Machamer. 2012. Inactivation of ceramide transfer protein during proapoptotic stress by Golgi disassembly and caspase cleavage. Biochem. J., 442:391-402.

Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M, "Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance", Cancer Cell. 2012 Apr 17;21(4):488-503. Selected for Cover.

Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN. A mechanosensory system governs myosin II accumulation in dividing cells. Mol. Biol. Cell 2012; 23(8): 1510-1523.

Galloway, J.F., Winter, A., Lee, K.H., Park, J., Dvoracek, C., Devreotes, P.N., and Searson, P.C.  2012 Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications.  Nanomedicine 8:1190-1199.

Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012; 8(4): e1002467. 

Barrowman J., Wiley, P.A., Hudon, S., Hrycyna, C.A. Michaelis, S. (2012) Human ZMPSTE24 disease mutations: residual enzymatic activity correlates with disease severity. Human Molecular Genetics 21:4084-4093.

Ruch, T.R. and C. E. Machamer. 2012. The coronavirus E protein: assembly and beyond.  Viruses 4:363-382. 

Chen, C-L., Wang, Y., Sesaki, H., and Iijima, M. Myosin I links PIP3 signaling to remodeling of the actin cytoskeleton in chemotaxis. Science Signaling. (2012). 5: ra10

Gjerstorff MF, Rösner HI, Pedersen CB, Greve KB, Schmidt S, Wilson KL, Mollenhauer J, Besir H, Poulsen FM, Møllegaard NE and Ditzel HJ. (2012) GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). PloS One 7:e45819.

Barkan R, Zahand AJ, Sarabi K, Lamm AT, Feinstein N, Haithcock E, Wilson KL, Liu J and Gruenbaum Y. (2012) Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function and mitosis. Molecular Biology of the Cell 23:543-552. 

Manczak, M., Sesaki, H., Kageyama, Y., and Reddy, P.H. (2012). Dynamin-related protein 1heterozygote knockout mice do not have synaptic and mitochondrial deficiencies. Biochim Biophys Acta. 1822(6):862-74.

Dickinson D, Robinson DN, Nelson WJ, Weis WI. α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev. Cell 2012; 23: 533-546.

Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN. Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J. 2012; 102(2): 238-247. 

Barrowman, J., Hamblet, C., Kane M.S., Michaelis, S. (2012) Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24. PLoS ONE 7: e32120.

Iglesias, P.A. and Devreotes, P.N.  2012 Biased excitable networks: how cells direct motion in response to gradients. Curr. Opin. Cell Biol., 757:451-468.

Ruch, T.R. and C.E. Machamer. 2012. A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. PLoS Pathogens 8(5):e1002674.

Chen, C-L. and Iijima, M. Myosin I: a new PIP3 effector in chemotaxis and phagocytosis. Commun. Integr. Biol. (2012). 5: 294-296

Miyamoto T., DeRose R., Suarez A., Ueno T., Chen M., Sun T.-p., Wolfgang M.J., Mukherjee C., Meyers D. and Inoue T. “Generation of Intracellular Logic Gates with Two Orthogonal Chemically Inducible Systems” Nature Chemical Biology (Accepted 2012)

Porter JR, Lee CSY, Espenshade PJ, Iglesias PA. 2012. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol. Biol. Cell 23:3764-3774.

Shao W, Espenshade PJ. 2012. Expanding roles for SREBP in metabolism. Cell Met. 16:414-419.

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman, JI, Jiang L, Kuo D, Tosti E, Kim H, Edelmann W, Keogh M, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. 2012. Hierarchical modularity and the evolution of genetic interactomes across species. Mol. Cell. 46:691-704.

Yamanaka, S., Campbell, N.R., An, F., Kuo, S.C., Potter, J.J., Mezey, E., Maitra, A., and Selaru, F. (2012) Coordinated effects of microRNA-494 induce G2/M arrest in human cholangiocarcinoma. Cell Cycle 11, 2729-38

Cai, H., Huang, C.H., Devreotes, P.N., and Iijima, M.  2012  Analysis of chemotaxis in Dictyostelium.  Methods Mol Biol 757:451-468.

Trushina, E., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T.M., Poduslo, J., and Dzeja, P. (2012). Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS ONE. 7(2): e32737.

2011

Estela, A., Pla-Martin. D., Sanchez-Piris. M., Sesaki. H., and Palau F. (2011). The Charcot-Marie-Tooth related gene GDAP1 complements cell cycle delay at G2/M in S. cerevisiae fis1 defective cells. J. Biol. Chem. 286: 36777-36786

Rivera Rosado, L.A., Horn, T.A., McGrath, S.C., Cotter, R.J. and Yang, J.T. (2011). Association between a4 integrin cytoplasmic tail and non-muscle myosin IIA regulates cell migration.  J. Cell Sci. 124, 483-492.

Zhou C, Slaughter BD, Unruh JR, Eldakak A, Rubinstein B, Li R. Motility and segregation of hsp104-associated protein aggregates in budding yeast. Cell. 2011;147:1186-1196. 

Yi K, Unruh JR, Deng M, Slaughter BD, Rubinstein B, Li R. Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes. Nat Cell Biol. 2011;13:1252-1258.

Issigonis M, Matunis E.  2011.  SnapShot: stem cell niches of the Drosophila testis and ovary.  Cell. 145: 994-994.e2.  PMID: 21663800.

Hobson, R.J., Q. Liu, S. Watanabe and E.M. Jorgensen. 2011. Complexin maintains vesicles in the primed state in C. elegans. Current Biology 21, p106-113. PMCID: PMC348763.

Gao JT, Guimera R, Li H, Pinto IM, Sales-Pardo M, Wai SC, Rubinstein B, Li R. Modular coherence of protein dynamics in yeast cell polarity system. Proc Natl Acad Sci U S A. 2011;108:7647-7652. 

Watanabe, S., A. Punge , G. Hollopeter , K.I. Willig, R.J. Hobson  , M.W. Davis , S.W. Hell , and E.M. Jorgensen. 2011. Protein localization in electron micrographs using fluorescence nanoscopy.  Nature Methods 8, p80-84. PMCID: PMC3059187.

Oikonomou, G., Perens, E. A., Lu, Y., Watanabe, S., Jorgensen, E. M., and Shaham, S. (2011). Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans. PLoS Biol. 9, e1001121. PMCID: PMC3153439.

Tang, M., Iijima, M., and Devreotes, P. Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle. (2011). 10: 2817-2818

Tang, M., Iijima, M., Kamimura, Y., Chen, L., Long, Y., and Devreotes, P. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol. Biol. Cell. (2011). 22: 437-47.

Maruyama, R., Grevengoed, E., Stempniewicz, P., Andrew, D.J. (2011) Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene fork headPLoS One 6(6): e20901. PMID: 21698206

Cai, H., and Devreotes, P.N. 2011 Moving in the right direction: How eukaryotic cells migrate along chemical gradients. Semin. Cell Dev. Biol. 22:834-841.

Ruch, T.R. and C.E. Machamer.  2011. The hydrophobic domain of the infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus.  J. Virol. 85:675-685.

Gao, R.C., Zhang, X.D., Sun, Y.H., Kamimura,Y., Mogilner, A., Devreotes, P.N., and Zhao, M.  2011.  Different roles of Membrane potentials in electrotaxis and chemotaxis of Dictyostelium Cells.  Eukaryot Cell, 10:1251-1256.

Zuckerman, D.M. S.W. Hicks, G. Charron, H.C. Hang, and C.E. Machamer.  2011.  Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta-1 adrendergic receptor. J. Biol. Chem. 286:19014-23.

Tamura, Y., Itoh, K. and Sesaki, H. (2011). SnapShot: Mitochondrial dynamics. Cell. 145:1158-11581e

Artemenko, Y., Swaney, K., and Devreotes, P.N.  2011.  Assessment of development and chemotaxis in Dictyostelium discoideum mutants.  Meth. Mol. Biol. 769:287-309.

Sheng, X. R., Matunis, E. L.  2011.  Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output.  Development 16:3367-3376.

Wang, Y., Steimle, P.A., Ren, Y., Ross, C.A., Robinson, D.N., Egelhoff, T.T., Sesaki, H., and Iijima, M. Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation. Mol. Biol. Cell. (2011). 22: 2270-2281

Kageyama, Y., Zhang, Z., and Sesaki, H. (2011). Mitochondrial division: molecular machinery and physiological functions. Curr. Opin. Cell Biol. 23: 427-34.

de Keijzer, S., Galloway, J., Devreotes, P.N., and Iglesias, P.A.  2011 Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane.  Biochimica et Biophysica Acta, 1808:1701-1708.

de Cuevas, M., Matunis, E. L.  2011.  The stem cell niche: Lessons from the Drosophila testis.  Development 14:2861-2969.  

Cohen, J.R., L.D. Lin and C.E. Machamer. 2011.  Identification of a Golgi targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein.  J. Virol. 85:5794-5803.

Wang, Y., Chen, C-L., and Iijima, M. Signaling mechanisms for chemotaxis. Development Growth and Differentiation (2011). 53: 495-502

Simon DN and Wilson KL. (2011) The nucleoskeleton as a dynamic genome-associated ‘network of networks.’ Nature Reviews Mol. Cell. Biol. 12:695-708.

Wilson KL and Dawson SC. (2011) Functional evolution of nuclear structure. J Cell Biology 195:171-181.

Montes de Oca RM, Andreassen PR and Wilson KL. (2011) Barrier to Autointegration Factor influences specific histone modifications. Nucleus 2:580-590. 

Ueno T., Falkenburger B.H., Pohlmeyer C., and Inoue T. “Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization” ScienceSignaling 4(203), ra87 (2011) (Cover Article)

Umeda N., Ueno T., Pohlmeyer C., Nagano T. and Inoue T. “A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity” Journal of American Chemical Society 133(1), 12-14 (2011) Note: “Scientist use light to move molecules within living cells” Science News article in ScienceDaily

Ewald AJ*, “Imaging the Cell Behavioral Basis of Branching Morphogenesis in 3D Organotypic and Whole Organ Cultures”, Imaging in Developmental Biology, A Laboratory Manual, 2nd Edition, Edited by James Sharpe and Rachel Wong, Cold Spring Harbor Laboratory Press, 2011. 

Stewart EV, Lloyd SJ, Burg JS, Nwosu CC, Lintner RE, Daza R, Russ C, Ponchner K, Nusbaum C, Espenshade PJ. 2011. Yeast SREBP cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J. Biol. Chem. 287:672-81.

Lee CSY, Yeh TL, Hughes BT, Espenshade PJ. 2011. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol. Cell 44:225-234.

Burg JS, Espenshade PJ. 2011. Glucose controls phosphoregulation of HMG-COA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast. J. Biol. Chem. 286:27139-46.

Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. 2011. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol. Cell 42:160-171.

Chung, S.-Y., Chavez, C. and Andrew, D.J. (2011) Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Developmental Biology 360: 160-172. PMID: 21963537

Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W.-J., Sereda, S., Clerc, P., Polster, B.M., Aja, S.M., Pletnikov, M.V., Kensler, T.W., Shirihai, O.S.,., Iijima, M., Hussain, M., and Sesaki, H. (2011). The Dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol. Biol. Cell. 22: 2235-2245. 

Nakamura. K., Nemani, V.M., Azarbal, F., Skibinski, G., Levy, J.M., Egami, K., Munishkina,L., Zhang, J., Gardner, B., Wakabayashi, J., Sesaki, H., Cheng, Y., Finkbeiner, S., Nussbaum,.R.L., Masliah, E., and Edwards, R.H. (2011). Direct membrane association drives mitochondrial fission by the Parkinson Disease-associated protein α-synuclein. J. Biol. Chem. 286: 20710-20726.

2010

Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137:1075-1084.

Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, Florens L, Sanderson BW, Hattem GL, Li R. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature. 2010;468:321-325.

Ou, C.-Y., Poon, V. Y., Maeder, C. I., Watanabe, S., Lehrman, E. K., Fu, A. K. Y., Park, M., Fu, W.-Y., Jorgensen, E. M., Ip, N. Y., et al. (2010). Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell 141, 846–858. PMCID: PMC3168554.

Issigonis M, Matunis E.  2010.  Previews. Niche today, gone tomorrow–progenitors create short-lived niche for stem cell specification.  Cell Stem Cell 6: 191-3.  PMID: 20207220.

Pellettieri, J., Fitzgerald, P., Watanabe, S., Mancuso, J., Green, D. R., and Sánchez Alvarado, A. (2010). Cell death and tissue remodeling in planarian regeneration. Dev. Biol. 338, 76–85. PMCID: PMC2835816.

QnAs with Peter N. Devreotes. 2010 Interview by Prashant Nair. PNAS, 107:19613. PMCID: PMC2993395

Cai, H., Das, S., Kamimura, Y., Comer, F.I., Parent, D.A., and Devreotes, P.N.  2010  Ras-mediated activation and inactivation of the TorC2-PKB pathway are critical for chemotaxis.  J. Cell Biol., 190:233-245. PMCID: PMC2930282

Kamimura, Y., Cai, H., Tang, M., and Devreotes, P.N. 2010 TorC2 and chemotaxis in Dictyostelium discoideum. In: The Enzymes (Michael N. Hall and Fuyuhiko Tamanoi, eds.). Acadmic Press, Volume 28, pp. 125-142.

Andrew, DJ and Ewald, AJ, “Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration”, Developmental Biology, 2010 May 1;341(1):34-55.

Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P.N., Robinson, D.N., and Iglesias, P.A.  2010  Automated characterization of cell shape changes during amoeboid motility by skeletonization.  BMC Syst. Biol., 4:33. PMCID: PMC2864235

Zhou Q, Kee Y-S, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Tran ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN. 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol. 2010; 20:1881-1889.

Chandran, S. and C.E. Machamer. 2010. Golgi organization and stress sensing.  The Golgi apparatus: Structure, Functions and Mechanisms.  (Nova Science, Inc, Hauppauge NY). 

Larson SM, Lee HJ, Hung P-h, Matthews LM, Robinson DN, Evans JP. Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and ezrin-radixin-moesin (ERM) proteins. Mol. Biol. Cell 2010; 21:3182-3192.

Cherry, C.M., Matunis, E.L. 2010.  Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome remodeling factor NURF.  Cell Stem Cell 6:557-567.

McBride, C.E. and C.E. Machamer.  2010. Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein.  Virology 405:139-148.

Simon DN, Zastrow MS, Wilson KL. (2010) Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. Nucleus 1:264-272. 

Wilson KL and Berk JM. (2010) The nuclear envelope at a glance. J Cell Science 123:1973-1978. 

Komatsu T., Kukelyansky I., McCaffery J.M., Ueno T., Varela L.C. and Inoue T. “Organelle-Specific, Rapid Induction of Molecular Activities and Membrane Tethering” Nature Methods 7, 206-208 (2010) Note: “Hopkins researchers put proteins right where they want them” Breaking News article in Genetic Engineering and Biotechnology News

Porter JR, Burg JS, Espenshade PJ, Iglesias PA. 2010. Ergosterol regulates SREBP cleavage in fission yeast. J. Biol. Chem. 285:41051-61.

Bien CM and Espenshade PJ. 2010. SREBP in fungi – Hypoxic transcription factors linked to pathogenesis. Eukaryotic Cell 9:352-9.

Fox, R.M., Hanlon, C.D. and Andrew, D.J. (2010) The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Journal of Cell Biology 191: 479-492. PMID: 21041443

Kerman, B.E. and Andrew, D.J. (2010) Staying alive: Dalmatian-mediated epigenetic blocking of apoptosis is essential for tissue maintenance. Developmental Dynamics 239:1609-21. PMID: 20503358

Swaney, K.F., Huang, C.H., Devreotes, P.N. 2010. Eukaryotic Chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 278:20445-20448.

Xiong, Y., Huang, C-H, Iglesias, P.A., and Devreotes, P.N. 2010. Cells navigate with a local-excitation, global-inhibition-biased excitable network. PNAS, 107:17079-17086.

Tamura, Y., Iijima, M., and Sesaki, H. Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. EMBO J. (2010). 29: 2875-2887.

Kamimura, Y., and Devreotes, P.N.  2010  Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis.  J Biol Chem 285(11):7938-7946. PMCID: PMC2832944

Kane LA, Youngman MJ, Jensen RE, Van Eyk JE. (2010). Phosphorylation of the F1-Fo ATP synthase beta subunit: functional and structural consequences assessed in a model system. Circ. Res. 106: 504-513.

Zhang, P., Wang, Y., Sesaki, H. and Iijima, M. Proteomic identification of PtdIns(3,4,5)P3-binding proteins in D. discoideum. Proc. Natl. Acad. Sci. USA. (2010). 107: 11829-11834.

2009

Liu J, Sun YD, Drubin DG, Oster GF. 2009. The mechanochemistry of endocytosis. PLoS Biology 2009; 7(9): e1000204.

Liu J, Sun YD, Drubin DG, Oster GF. 2009. Themechanochemistry of endocytosis. PLoS Biology 7(9): e1000204.

Slaughter BD, Das A, Schwartz JW, Rubinstein B, Li R. Dual modes of cdc42 recycling fine-tune polarized morphogenesis. Dev Cell. 2009;17:823-835.

Sheng XR, Matunis EL.  2009.  Make room for dedifferentiation.  Fly 3: 283-5. PMID: 19923919.

Barnes, N., Bartee, M.Y., Braiterman, L., Gupta,A., Ustiyan, V., Zuzel, V., Kaplan, J.H., Hubbard, A.L., Lutsenko, S. 2009. Cell specific trafficking suggests a new role for renal ATPB in intracellular copper storage. Traffic 10:767-779.

Pramanik, Md K., Iijima, M., Iwadate, Y., and Yumura, S. PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells. Genes to Cells. (2009). 14: 821-34.

Metzger MB, and Michaelis S. (2009) Analysis of Quality Control Substrates in Distinct Cellular Compartments Reveals a Unique Role for Rpn4p in Tolerating Misfolded Membrane Proteins Mol. Biol. Cell 20:1006-1019.

Barrowman, J., and Michaelis, S. (2009) ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders. Biological Chemistry 390: 761-773.

Issigonis, M., Tulina, N., de Cuevas, M., Brawley, C., Sandler, L., Matunis, E. 2009.  JAK-STAT signal inhibition regulates competition within the Drosophila testis stem cell niche.  Science 326:153-6.

Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T.W., Iijima, M., and Sesaki, H. (2009). The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J. Cell Biol. 186: 805-816

Sheng, X.R., Brawley, C.M., Matunis, E.L. 2009.  Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis.  Cell Stem Cell 5:191-203.

Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock, RS, Robinson DN. Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr. Biol. 2009; 19(17):1421-1428.

Franca-Koh, J., Willard, S.S., and Devreotes, P.N. 2009 G-Protein Signaling in Chemotaxis. In: Ralph A. Bradshaw and Edward A. Dennis, editors, Handbook of Cell Signaling 2nd edition. Oxford: Academic Press, pp. 1705-1712.

Tamura, Y., Endo, T., , Iijima, M. and Sesaki, H. (2009). Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J. Cell Biol. 185: 1029-1045

Sheng, X.R., Posenau, T., Gumulak-Smith, J.J., Matunis, E., Van Doren, M., Wawersik, M., 2009.  Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis.  Dev. Biol. 334:335-344.

McBride, C.E. and C.E. Machamer.  2009. A single tyrosine in the SARS coronavirus membrane protein is important for interaction with the spike protein.  J. Virol. 84:1891-1901.

Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN and Wilson KL. (2009) Barrier to Autointegration Factor proteome reveals chromatin-regulatory partners. PLoS One e7050. 

Tifft KE, Bradbury KA and Wilson KL. (2009) Tyrosine phosphorylation of nuclear membrane protein emerin by Src, Abl and other kinases. J Cell Science 122:3780-3790. 

Rahdar M., Inoue T., Meyer T., Zhang J., Vazquez F., and Devreotes P.N. “A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN” Proc. Natl. Acad. Sci. U S A. 106(2):480-5 (2009)

Braiterman, L., Nyasae, L., Guo, L., Bustos, R., Lutsenko, S., Hubbard, A. 2009. Apical targeting and golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B. Am. J. Physiol. Gastrointest. Liver Physiology, 296(2):G433-444.

Ewald, AJ, Werb, Z, Egeblad, M, “In vivo imaging of tumor – immune cell interactions,” Live Cell Imaging 2nd Edition, Cold Spring Harbor Laboratory Press, 2009

Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, and Espenshade PJ. 2009. C. neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol. Microbiol. 74:672-690.

Lee CY, Stewart EV, Hughes BT and Espenshade PJ. 2009. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. EMBO J. 28:135-43.

Fisher, C.I., and Kuo, S.C. (2009) Filament rigidity causes F-actin depletion from nonbinding surfaces. PNAS 106, 133-138

Chung, S.-Y., Vining, M.S., Bradley, P.L., Chan, C.-C., Wharton, K.A. and Andrew, D.J. (2009) Serrano (Sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genetics 5(11): e1000746. PMID: 19956736.

Kamimura, Y., Tang, M., and Devreotes, P.N. 2009 Assays for Chemotaxis and Chemoattractant-Stimulated TorC2 Activation and PKB Substrate Phosphorylation in Dictyostelium. In: Chemotaxis, Methods in Molecular Biology, vol. 571. (T. Jin and D. Hereld, eds.). Humana Press.

Tamura, Y., Harada, Y., Shiota, T., Yamano, K., Watanabe, K., Yokota, M., Yamamoto, H., Sesaki, H., and Endo, T. (2009). Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J. Cell Biol. 184: 129-141

2008

Dikeman, D.A., Rivera Rosado, L.A., Horn, T.A., Alves, C.S., Konstantopoulos, K. and Yang, J.T. (2008).  α4β1 integrin regulates directionally persistent cell migration in response to shear flow stimulation.  Am. J. Physiol. Cell Physiol., 295, 151-159.  

Liu J, Desai A, Onuchic JN, Hwa T. 2008. An integrated mechano-biochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis. PNAS 2008; 105: 13752-13757.

Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, Walton K, Perera A, Staehling-Hampton K, Seidel CW, Li R. Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor. Cell. 2008;135:879-893.  

Egeblad* M, Ewald* AJ, Asketraud HA, Truitt M, Welm B, Bainbridge E, Peeters G, Krummel M, Werb Z, “Imaging stromal cells in different tumor microenvironments by spinning disk confocal microscopy”, Disease Models and Mechanisms. 2008 Sep/Oct; 1(2/3): 155-67. * = Co-First Authors. PMC2562195

Nakatsukasa, K., Huyer, G., Michaelis, S., and Brodsky J. L. (2008) Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein. Cell 132: 101-112

Lu, PF, Ewald, AJ, Werb, Z, Martin, G. Genetic mosaic analysis reveals FGF receptor 2 is required in terminal end buds during mammary gland branching morphogenesis. Developmental Biology, 2008 Sep 1; 321(1):77-87.

Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.* 2008. Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics. Curr. Biol. 18: 471-480. PMCID: PMC2361134

Hudon, S. E., Coffinier, C., Michaelis, S., Fong, L. G., Young, S. G., and Hrycyna, C. A. (2008) HIV-Protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Comm. 374:365-368

Kerman, B.E., Cheshire, A.M., Myat, M.M., and Andrew, D.J. (2008) Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin.  Developmental Biology 320:  278-288. PMID: 18585700

Jensen, R.E. et al. (2008). What happens when Trypanosoma brucei leaves Africa. Trends Parasitol. 24: 428-431.

Chandran, S. and C.E. Machamer.  2008.  Acute perturbations in Golgi organization impact de novo sphingomyelin synthesis.  Traffic 9:1894-1904.

Inoue T. and Meyer T. “Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration” PLoS ONE 3(8), e3068 (2008)

Yamano K, Yatsukawa Y, Esaki M, Hobbs AE, Jensen RE, Endo T. (2008). Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import. J. Biol. Chem. 283(7): 3799-3807.

Ewald, AJ, Brenot, A, Duong, M, Chan, BC, Werb, Z. Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis. Developmental Cell, 2008 Apr; 14(4): 570-81.

Tang, L., Franca-Koh, J., Xiong, Y., Chen, M-Y., Long, Y., Bickford, R.M., Knecht, D.A., Iglesias, P.A., and Devreotes, P.N. 2008 Tsunami, the Dictyostelium homolog of the Fused kinase is required for polarization and chemotaxis. Genes Dev. 22:2278-2290. PMCID: PMC2518819

Alder NN, Jensen RE, Johnson AE.  (2008) Fluorescence mapping of mitochondrial TIM23 complex reveals a water-facing, substrate-interacting helix surface. Cell 134: 439-450.

Barrowman, J., Hamblet, C., George, C.M., and Michaelis, S. (2008) Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. Mol. Biol. Cell 12:5398-5408

Metzger, M. B. Maurer, M. J., Dancy, B. M., and Michaelis, S. (2008) Degradation of a cytosolic protein requires ER-associated degradation (ERAD) machinery. J. Biol. Chem. 283:32302-32316

Kamimura, Y., Xiong, Y., Iglesias, P.A., Hoeller, O., Bolourani, P. and Devreotes, P.N. 2008 PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Bio. July 22; 18(14):1034-43. PMCID: PMC4018231

Alder NN, Sutherland J, Buhring AJ, Jensen RE, Johnson AE.  (2008) Quaternary structure of the mitochondrial TIM23 complex reveals dynamic association between Tim23p and other subunits. Mol. Biol. Cell 19: 159-170.

Hogue, B.G., and C.E. Machamer. 2008. Coronavirus structural proteins and virus assembly. Nidoviruses. Edited by S. Perlman, T. Gallagher, and E. Snijder. (ASM), pp. 179-200.

Fivaz M., Bandara S., Inoue T. and Meyer T. "Robust neuronal symmetry breaking by Ras-triggered local positive feedback" Current Biology 18, 44-50 (2008)

Kouros-Mehr, H, Bechis, SK, Slorach, EM, Littlepage, LE, Egeblad, M, Ewald, AJ, Pai, SY, Ho, IC, Werb, Z. Gata-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell, 2008, Feb; 13(2): 141-52.

Burg JS, Powell DW, Chai R, Hughes AL, Link AJ and Espenshade PJ. 2008. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metabolism 8:522-31.

Hughes BT and Espenshade PJ. 2008. Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. EMBO J. 27:1491-1501.

Iglesias, P.A. and Devreotes, P.N. 2008 Navigating through models of chemotaxis. Curr. Opin. Cell Bio., 20(1):35-40.

Dunn, C.D. et al. (2008) Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol. Biol. Cell 19: 5387-5397.

2007

Chen, L., Iijima, M., Tang, M., Landree, M.A. Huang, Y.E., Xiong, Y., Iglesias, P.A., Devreotes, P.N. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Developmental Cell. Developmental Cell. (2007) 12: 603-614.

Hammarlund, M., Palfreyman, M. T., Watanabe, S., Olsen, S., and Jorgensen, E. M. (2007). Open syntaxin docks synaptic vesicles. PLoS Biol. 5, e198. PMCID: PMC3048763.

Yoshino, R., Morio, T., Yamada, Y., Kuwayama, H., Sameshima, M., Tanaka, Y., Sesaki, H., and Iijima, M. Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium Eukaryot Cell. (2007) 6: 2419-2428. 

Fata, J, Mora, H, Ewald, AJ, Zhang, H, Yao, E, Werb, Z, Bissell, M. The MAPK ERK-1,2 pathway integrates distinct and antagonistic signals from TGF± and FGF7 in morphogenesis of mouse mammary epithelium. Developmental Biology, 2007, Jun 1; 306(1):193-207.

Cerveny, K.L. et al. (2007) Yeast mitochondrial division and distribution require the cortical Num1 protein. Dev. Cell 12: 363-375.

Sbodio, J.I. and C.E. Machamer.  2007.  Identification of a redox sensitive cysteine residue in GCP60 that regulates its interaction with golgin-160.  J. Biol. Chem 282:29874-29881.

Davis, A.J. et al. (2007) The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import. Mol. Biol. Cell 18: 475-486.

McBride, C.E., J. Li, and C.E. Machamer. 2007. The cytoplasmic tail of the spike protein of the severe acute respiratory syndrome coronavirus contains a novel endoplasmic reticulum retrieval signal that binds COPI and promotes interaction with membrane protein. J. Virol., 81:2418-2428.

Page-McCaw*, A, Ewald*, AJ, Werb, Z. Matrixmetalloproteinases and the regulation of tissue remodeling. Nature Reviews Molecular Cell Biology, 2007, Mar; 8(3): 221-33. *Co-First Authors.

Holaska JM and Wilson KL. (2007) An emerin ‘proteome’: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing and nuclear architecture. Biochemistry 46, 8897-908. 

Paumi, C. M., Menendez, J., Arnoldo, A, Engels, K, Iyer, K. R., Thaminy, S, Georgiev, O., Barral Y., *Michaelis, S, and *Stagljar, I. (2007) Mapping Protein-Protein Interactions for the Yeast ABC Transporter Ycf1p by Integrated Split-Ubiquitin Membrane Yeast Two-Hybrid (iMYTH) Analysis. Molecular Cell 26: 15-25. * Co-corresponding senior authors.

Sasaki, A.T., Janetopoulos, C., Lee, S., Charest, P.G., Takeda, K., Sundheimer, L.W., Meili, R., , Devreotes, P.N.and Firtel, R.A. 2007 G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J. Cell Bio. 178(2):185-191.

Meisinger, C. et al. (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 26: 2229-2239.

Cerveny, K.L., Studer, S.L., Jensen, R.E., and Sesaki, H. (2007). Yeast mitochondrial division and distribution requires the cortical Num1 protein. Developmental Cell. 12: 363-375.

Buszczak, M., Paterno, S., Lighthouse D., Bachman J., Plank J., Owen S., Skora A., Nystul T., Ohlstein B., Allen A., Wilhelm J., Murphy T., Levis B., Matunis. E., Srivali N., Hoskins R., Spradling A.  2007.  The Carnegie protein trap library: a versatile tool for Drosophila developmental studies.  Genetics 175:1501-1531. 

Nyasae, L., Bustos, R., Braiterman, L., Eipper, B., A. Hubbard. 2007. Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites. Am J Physiol Gastrointest Liver Physiol. 292(4):G1181-94.

Margalit A, Neufeld E, Feinstein N, Wilson KL, Podbilewicz B and Gruenbaum Y (2007).  Barrier to autointegration factor (BAF) blocks premature cell fusion and maintains adult muscle integrity in C. elegans. J Cell Biology 178:661-673. 

Peixoto, P.M. et al. (2007) Awaking TIM22: A dynamic ligand-gated channel for protein insertion in the mitochondrial inner membrane. J. Biol. Chem. 282: 18694-18701.

Cerveny, K.L., Tamura, Y., Zhang, Z., and Jensen, R.E. and Sesaki, H. (2007). Regulation of mitochondrial fusion and division. Trends Cell Biol. 17: 563-569.

2006

Grazioli, A, Alves, C.S., Konstantopoulos, K and Yang, J.T. (2006). Defective blood vessel development and pericyte/pvSMC distribution in α4 integrin-deficient mouse embryos. Dev. Biol. 393,165-177.

Sesaki, H. Dunn, C.D., Iijima, M., Shepard, K.A., Yaffe, M.P., Machamer, C.E., and Jensen, R.E. (2006). Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J. Cell Biol. 173: 651-658. 

Somesh, B.P., Vlahou, G., Iijima, M., Insall, R.H., Devreotes, P.N., Rivero, F. RacG regulates morphology, phagocytosis and chemotaxis. Eukaryot Cell. (2006) 5: 1648-1663.

Effler JC, Kee Y-S, Berk JM, Tran MN, Iglesias PA, Robinson DN.* Mitosis-specific mechanosensing and contractile protein redistribution control cell shape. Curr. Biol. 2006; 16(19):1962-1967. PMCID: PMC2474462

Hicks, S.W., T.A. Horn, J.M. McCaffery, D.M. Zuckerman,and C.E. Machamer. 2006. Golgin-160 promotes cell surface expression of the beta-1-adrenergic receptor. Traffic 7:1666-1677.

Williams, D., S.W. Hicks, C.E. Machamer, and J.E. Pessin. 2006. Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes., Molec. Biol. Cell 17:5346-5355.

Zastrow MS, Flaherty DB, Benian GM and Wilson KL (2006). Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. J. Cell Science 119:239-249.

Montes de Oca R, Lee KK and Wilson KL (2006). Binding of barrier-to-autointegration factor (BAF) to histone H3 and selected linker histones including H1.1.  J Biological Chemistry 280:42252-62

Terry, N.A, Tulina, N., Matunis, E., DiNardo S.  2006.  Novel regulators revealed by profiling Drosophila testis stem cells within their niche.  Dev. Biol. 294:246-257. 

Sbodio, J.I., S.W. Hicks, D. Simon, and C.E. Machamer. 2006. GCP60 preferentially interacts with a caspase-generated golgin-160 fragment. J. Biol. Chem. 281:27924-27931.

Suh BC*, Inoue T*, Meyer T, and Hille B. “Rapid chemically-induced changes of PtdIns(4,5)P2 gate KCNQ ion channels” Science 314, 1454-1457 (2006) (*Contributed Equally) Note: “Perspectives” (Science 314, 1402-1403 (2006)), “Editor’s Choice” (Science STKE 364, tw410 (2006)), “Spotlight” (ACS Chem. Biol. 1, 608 (2006)), “Research Highlights” (Nature Methods 4, 7 (2007))

Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, and Meyer T. “PI(3,4,5)P3 and PI(4,5)P2 lipids target Ras, Rho, Arf and Rab GTPases to the plasma membrane” Science 314, 1458-1461 (2006)

Girard, K.D., Kuo, S.C., and Robinson, D.N. (2006) Dictyostelium myosin-II mechanochemistry promotes active behavior of the cortex on long time-scales. PNAS 103, 2103-2108

Abrams, E.W., Mihoulides, W.K. and Andrew, D.J. (2006) Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4áSG1 and PH4áSG2. Development 133: 3517-3527. PMID: 16914497.

Jensen, R.E. and Sesaki, H. (2006) Ahead of the curve: mitochondrial fusion and phospholipase D. Nat. Cell Biol. 8:1215-2157.

2005

Song S, Ewald, AJ, Stallcup B. Werb, Z. and G. Bergers. PDGFR±+ perivascular progenitor cells in tumors regulate pericyte differentiation and vascular survival. Nature Cell Biology, 2005, Sep; 7(9) :870-9. Must Read 6.0 on Faculty of 1000, 10/28/05.

Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P.N. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Developmental Cell. (2005) 8: 467-477.

Zhang W., Robinson DN.* Balance of actively generated contractile and resistive forces controls cytokinesis dynamics. Proc. Natl. Acad. Sci. USA 2005; 102(20):7186-7191. PMCID: PMC1129136

Abrams, E.W. and Andrew, D.J. (2005) CrebA regulates secretory activity in the salivary gland and epidermis.  Development 132: 2743-2758. PMID: 15901661

Youn, S., E.W. Collisson, and C.E. Machamer. 2005. Contribution of trafficking signals in the cytoplasmic tail of the infectious bronchitis virus spike protein to virus infection. J. Virol. 79 13209-13217.

Pendleton, A.R., and C. E. Machamer. 2005. Infectious bronchitis virus 3a protein localizes to a unique punctate domain of the smooth endoplasmic reticulum. J. Virol.,79:6142-6151.

Mallampalli, M. P., Huyer, G., Bendale, P., Gelb, M. H., and Michaelis, S. (2005) Inhibiting Farnesylation Reverses the Nuclear Morphology Defect in a HeLa Cell Model for Hutchinson-Gilford Progeria Syndrome, Proc Natl. Acad Sci. USA 102:14416-14421.

Young, S. G. Fong, L., and Michaelis, S.  (2005) Prelamin A, Zmpste24, misshapen cell nuclei, and progeria- new evidence suggesting that protein farnesylation could be important for disease pathogenesis.  Journal of Lipid Research 46:2531-2558.

Wawersik, M., Milutinovich, A. Matunis, E., Williams, B. Van Doren, M.  2005.  Somatic control of germline sexual differentiation is mediated by the JAK/STAT pathway. Nature 436:563-567.  

Hicks, S.W. and C.E. Machamer. 2005. Golgi structure in stress sensing and apoptosis. Biochim. Biophys. Acta 1744:406-414.

Maag, R., M. Mancini,R, A. Rosen and C. E. Machamer. 2005. Caspase-resistant golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. Molec. Biol. Cell 16:3019-2027.

Hicks, S.W. and C.E. Machamer. 2005. Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST. J. Biol. Chem 280:28944-28951.

Inoue T, Heo WD, Grimley JS, Wandless TJ, and Meyer T. “Inducible translocation strategies to rapidly activate and inhibit small GTPase signaling pathways” Nature Methods 2, 415-418 (2005)

Guo, Y, L. Nyasae, L. T. Braiterman, and A. L. Hubbard. 2005. N-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Amer J. Physiol., GI/Liver 289(5):G904-16.

Hughes AL, Todd BL, Espenshade PJ. 2005. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120:831-842.

2004

Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8951-6. PMC428453

Brawley, C, Matunis, E. 2004. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivoScience 304:1331-1334.

Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F., Devreotes, P.N. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J. Biol. Chem. (2004) 16: 16606-16613.

Ewald, AJ, Peyrot, S, Tyszka, JM, Fraser, SE, Wallingford, J. Regional requirements for Dishevelled signaling during Xenopus gastrulation: Separable effects on blastopore closure, mesendoderm internalization, and archenteron formation. Development, 2004, Dec Part 2; 131(24): 6195-6209.

Girard, K.D., Chaney, C., Delannoy, M., Kuo, S.C., and Robinson, D.N. (2004) Dynacortin contributes to cortical viscoelasticity and helps define the shape changes of cytokinesis. EMBO J 23(7), 1536-46

2003

Wallenfang MR, Matunis E.  2003.  Developmental biology. Orienting stem cells.  Science. 301: 1490-1.  PMID: 12970553.

Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes” Chem. Biol. 10, 503-509 (2003) Note: “Cover art”

Bradley, P.L., Myat, M.M., Comeaux, C. and Andrew, D.J. (2003) Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.  Developmental Biology 257:  249-262. PMID: 12729556

Kupfer, A. and Kupfer, H. (2003) Imaging immune cell interactions and functions: SMACs and the immunological synapse. Seminars in Immunology 19:4712-4722.

Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P.N., Snyder, S.H. Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions. Cell. (2003) 114: 559-572.

Chen, H, Detmer, SA, Ewald AJ, Griffin, EE, Fraser SE, and Chan, DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. Journal of Cell Biology, 2003, Jan 20; 160(2): 189-200.

McGrath, J.L., Eungdamrong, J., Fisher, C.I., Peng, F., Mahadevan, L., Mitchison, T.J., and Kuo, S.C. (2003) The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol 13, 329-332

2002

Pinco, K. A., He W., and Yang, J. T. (2002). α4β1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism. Mol. Biol. Cell 13, 3203-3217.

Sengbusch, J.K., He W., Pinco, K.A. and Yang, J.T. (2002). Dual functions of α4β1 integrin in epicardial development: initial migration and long term attachment. J. Cell Biol.157, 873-882. 

Iijima, M., Huang, Y.E., Devreotes, P.N. Temporal and spatial regulation of chemotaxis. Developmental Cell. (2002) 4; 469-478.

Freiberg, B. A., Kupfer, H., Maslanik, W., Delli, J., Kappler, J., Zaller, D.M. and Kupfer, A. (2002) Staging and resetting T cell activation in SMACs. Nat. Immunol. 18:6201-6208.

Myat, M.M. and Andrew, D.J. (2002) Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Cell 111:879-891. PMID: 12526813.

Iijima, M. and Devreotes, P. N. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610 (Cover).

2001

Sesaki, H. and Jensen, R.E. (2001). UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol. 152:1123-34. 

Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor” Chem. Biol. 8, 9-15 (2001)

Bradley, P.L. and Andrew, D.J. (2001) ribbon encodes a BTB-containing transcription factor required for directed cell migration.  Development 128: 3001-3015. PMID: 11532922

Tulina, N., Matunis, E. 2001.  Control of Stem cell self-renewal in Drosophila  spermatogenesis by Jak-STAT signaling.  Science 294: 2546-2549.

Potter, T.A., K. Grebe, B. Freiberg, and Kupfer, A. (2001) Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 92:819-828.

Wallingford, JB, Ewald, AJ, Harland, RM and Fraser, SE. Calcium signaling during convergent extension in Xenopus. Current Biology, 2001, May 1; 11(9):652-661. Selected for Cover.

Janetopoulos, C., Jin, T. and Devreotes, P.N. 2001. Receptor mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411.

2000

Robinson DN*, Spudich JA. Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium cytokinesis mutant. J. Cell Biol. 2000; 150(4):823-838. PMCID: PMC2175282

Myat, M.M. and Andrew, D.J. (2000) Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia.  Development 127: 679-691. PMID: 10648227

Myat, M.M. and Andrew, D.J. (2000) FORK HEAD prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands.  Development 127: 4217-4226. PMID: 10976053

Kupfer, A. (2000) Breaking up receptor alliances: the parting of CD3 and CD4. Nature Medicine 16:2248-2254.

Kuo, S.C., and McGrath, J. L. (2000) Steps and fluctuations of Listeria monocytogenes during actin-based motility. Nature 407, 1026-9

Yamada, S., Wirtz, D., and Kuo, S.C. (2000) Mechanics of living cells measured by laser tracking microrheology (LTM). Biophys. J. 78, 1736-47.

1999

Sesaki, H. and Jensen, R.E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147: 699-706. 

Parent, C. and Devreotes, P.N. 1999. A Cell's Sense of Direction. Science, 284, 765-770.

1998

Monks, C.R.F., B.A. Freiberg, H. Kupfer, N. Sciaky, and Kupfer, A. (1998) Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 166:4773-4779.

Parent, C., Blacklock, B., Froelich, W., Murphy, D. and Devreotes, P.N. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell, 95, 81-91.

1997

Chen MY, Long Y, Devreotes PN. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev. 1997 Dec 1;11(23):3218-31. PMC316743

Xiao Z, Zhang N, Murphy DB, Devreotes PN. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J Cell Biol. 1997 Oct 20;139(2):365-74. PMC2139806.

Monks, C.R.F., Kupfer, H., Tamir, I., Barlow, A., and Kupfer, A. (1997) Selective modulation of protein kinase C-theta during T-cell activation. Nature 46 (Suppl): S67-S72.

1996

Isaac, D.D. and Andrew, D.J. (1996) Tubulogenesis in Drosophila:  A requirement for the trachealess gene product.  Genes and Development 10: 103-117. PMID: 8557189

Bhanot, P., Brink, M., Samos, C.H., Hsieh, J.-C., Wang, Y., Macke, J.P., Andrew, D., Nathans, J., and Nusse, R. (1996) Dfz2, a new member of the frizzled family in Drosophila, functions as a receptor for Wingless.  Nature 382: 225-230.  PMID: 8717036

1994

Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J Cell Biol. 1994 Sep;126(6):1537-45. PMC2290948

1993

Lilly P, Wu L, Welker DL, Devreotes PN. A G-protein beta-subunit is essential for Dictyostelium development. Genes Dev. 1993 Jun;7(6):986-95. PMID: 8099335.

1992

Pitt, G.S., Milona, N., Borleis, J., Lin, K.C., Reed, R.R. and Devreotes, P.N. 1992. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyosteilum development. Cell 69, 305-315.

1988

Klein, P.S., Sun, T.L., Saxe, C.L. III, Kimmel, A.R., Johnson, R.L. and Devreotes, P.N.  1988.  A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241, 1467-1472.

1981

Tomchik KJ, Devreotes PN. Adenosine 3',5'-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution–fluorography. Science. 1981 Apr 24;212(4493):443-6. (Cover Article). PMID: 6259734

Tomchik, K.J. and Devreotes, P.N. 1981. Cyclic AMP waves in Dictyostelium discoideum: A demonstration by isotope dilution fluorography. Science 212, 443-446. (COVER)

1979

Devreotes PN, Steck TL. Cyclic 3',5' AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. J Cell Biol. 1979 Feb;80(2):300-9. PMC2110342