Mikala Egeblad, Ph.D.
Bloomberg Distinguished Professor
mikala.egeblad@jhmi.edu
410-955-9938
Johns Hopkins University School of Medicine
855 N. Wolfe Street, 451 Rangos Bldg
Further Information
Triggering the body’s defenses to fight cancer.Nautilus, November13 (2021)
The Scientist, May 28 (2020)
Scientific American, April 28 (2020)
The Scientist, October 1 (2019)
Oncology Times, January 5 (2018)
Publications
Maiorino, L., Shevik, M., Adrover, J.M., Han, X., Georgas, E., Wilkinson, J.E., Seidner, H., Foerschner, L., Tuveson, D.A., Qin, Y.-X., and Egeblad M. (2022) Longitudinal intravital imaging through clear silicone windows. J Vis Exp, 179, e62757, doi:10.3791/6275.
Maiorino, L., Daßler-Plenker, J., Sun, L, and Egeblad, M. (2022) Innate Immunity and Cancer Pathophysiology. Annu Rev Pathol. 2021. doi: 10.1146/annurev-pathmechdis-032221-115501.
Adrover, J.M., Carrau, L., Daßler-Plenker, J., Bram, Y., Chandar, V., Houghton, S., Redmond, D., Merrill, J.R., Shevik, M., tenOever, B.R., Lyons, S.K., Schwartz, R.E., and Egeblad M. (2022) Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection. JCI Insight, 7: e157342. https://doi.org/10.1172/jci.insight.157342.
Quail, D.F., Amulic, B., Aziz, M., Barnes, B.J., Eruslanov, E., Fridlender, Z.G., Goodridge, H.S., Granot, Z., Hidalgo, A., Huttenlocher, A., Kaplan, M.J., Malanchi, I., Merghoub, T., Meylan, E., Mittal, V., Pittet, M.J., Rubio-Ponce, A., Udalova, I.A., van den Berg, T.K., Wagner, D.D., Wang., P., Zychlinsky, A., de Visser, K.E., Egeblad M., Kubes, P. (2022) Neutrophil phenotypes and functions in cancer: a consensus statement J Exp Med , 219(6):e20220011. doi: 10.1084/jem.20220011.
Wu, XS, He, X.-Y., Ipsaro, J.J., Huang, Y.-H., Preall, J.B., Ng, D., Shue, Y.T., Egeblad M., Joshua-Tor, L., and Vakoc, C.R. (2022) OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature doi: 10.1038/s41586-022-04842-7.
Song, D., Adrover, J.M, Felice, C., Christensen, L., He, X.-Y., Merrill, J.R., Wilkinson, J.E., Janowitz, T. Lyons, S.K., Egeblad M., and Tonks, N.K. (2022) PTP1B inhibitors regulate the CXCR4-CXCR2 signaling axis in neutrophils and protect against acute lung injury. JCI Insight 7(14):e158199. doi: 10.1172/jci.insight.158199.
Olsen T., Caruana D., Cheslack-Postava K., Szema A., Thieme J., Kiss A., Singh M., Smith G., McClain S., Glotch T., Esposito M., Promisloff R., Ng D., He X., Egeblad M., Kew R., Szema A. (2022) Iraq/Afghanistan war lung injury reflects burn pits exposure. Sci Rep. 12(1):14671. doi: 10.1038/s41598-022-18252-2.
Fujii T., Rehman H., Chung S.Y., Shen J., Newman J., Wu V., Hines A., Azimi-Nekoo E., Fayyaz F., Lee M., Raptis G., Egeblad M., and Zhu X. (2021) Treatment with Granulocyte-colony Stimulating Factor (G-CSF) is not associated with Increased Risk of Brain Metastasis in Patients with De Novo Stage IV Breast Cancer. J Cancer. 12:5687-5692. doi: 10.7150/jca.63159. eCollection 2021.
Sun L., Kees T., Almeida A.S., Liu B., He X.Y., Ng D., Han X., Spector D.L., McNeish I.A., Gimotty P., Adams S., and Egeblad M. (2021) Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis. Cancer Cell, 39, 1361-1374.
Barth N.D., Mendive-Tapia L., Subiros-Funosas R., Ghashghaei O., Lavilla R., Maiorino L., He X.Y., Dransfield I., Egeblad M., and Vendrell M. (2021) A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy-Induced Cancer Cell Death. Angew Chem Int Ed Engl. doi: 10.1002/anie.202113020.
Middleton, E.A., He,X.-Y., Denorme, F., Campbell, R.A., Ng, D., Salvatore, S.P., Mostyka, M., Baxter-Stoltzfus, A., Borczuk, A.C., Loda, M., Cody, M.J., Manne, B.K., Portier, I., Harris, E.S., Petrey, A.C., Beswick,E.J., Caulin, A.F., Lovino, A., Abegglen, L.M., Weyrich, A.S., Rondina, M.T., Egeblad M., Schiffman, J.D., and Yost, C.C.(2020). Neutrophil extracellular traps (NETs) contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136:1169-1179. doi.org/10.1182/blood.2020007008.
Sindhwani, S., Syed, A.M., Ngai, J., Kingston, B.R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N.U., Hoang, T., Wu, J.L.Y., Wilhelm, S., Zilman, A., Gadde, S., Sulaiman, A., Ouyang, B., Lin, Z., Wang, L., Egeblad M., and Chan, W.C.W. (2020). The entry of nanoparticles into solid tumours. Nat Mater, 19, 566-575. doi: 10.1038/s41563-019-0566-2.
Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J.A., Blair, C.N., Weber, A., Barnes, B.J., Egeblad M., Woods, R.J., Kanthi, Y., and Knight, J.S. (2020). Neutrophil extracellular traps in COVID-19. JCI Insight, 5:138999. doi: 10.1172/jci.insight.138999.
Somerville, T.D., Biffi, G., Daßler-Plenker, J., Hur, S.K., He, X.Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O.E., Preall, J.B., Hollingsworth, M.A.,Egeblad M., Tuveson, D.A., and Vakoc, C.R. (2020). Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife 9:e53381. doi: 10.7554/eLife.53381.
Weber, A.G., Chau, A.S.,Egeblad M., Barnes, B.J., and Janowitz, T. (2020). Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: A case series. Mol Med. 26:91. doi: 10.1186/s10020-020-00215-w.
Barth, N., Subiros-Funosas, R., Mendive-Tapia, L., Duffin, R., Shields, M., Cartwright, J., Henriques, S., Sot, J., Goñi, F., Lavilla, R., Marwick, J., Vermeren, S., Rossi, A., Egeblad M., Dransfield, I., and Vendrell, M. (2020). A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis. Nat Comm, 11:4027. doi: 10.1038/s41467-020-17772-7.
Rozenblit, M., Hendrickx, W., Heguy, A., Chiriboga, L., Loomis C., Ray, K., Darvishian, F., Egeblad M., Demaria, S., Marincola, F., Bedognetti, D., and Adams, S. (2019). Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod. Sci Rep, 9(1), 8572. doi: 10.1038/s41598-019-42784-9.
Bružas, E., Egeblad M. (2018) Spotlight: Bone talk: activated osteoblasts promote lung cancer growth. Trends Mol Med, Published online: February 02, 2018
Pommier A, Anaparthy N, Memos N, Kelley ZL, Gouronnec A, Yan R, Auffray C, Albrengues J, Egeblad M., Iacobuzio-Donahue CA, Lyons SK, Fearon DT. (2018) Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science 360. pii: eaao4908. doi: 10.1126/science.aao4908
Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M., Shi J, Vakoc CR. (2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev 32:915-928. doi: 10.1101/gad.314815.118
Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Küttner V, Bružas E, Maiorino L, Bautista C, Carmona EM, Gimotty PA, Fearon DT, Chang K, Lyons SK, Pinkerton KE, Trotman LC, Goldberg MS, Yeh JT, Egeblad M. (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361. pii: eaao4227. doi: 10.1126/science.aao4227
Fein, M.R., He, X.-Y., Almeida, A.S., Bružas, E., Pommier, A., Yan, R., Eberhardt, A., Fearon, D.T., Van Aelst L., Wilkinson, J.E., dos Santos, C.O., and Egeblad M. (2018). Cancer cell CCR2 orchestrates suppression of the adaptive immune response. JEM, 217: e20181551. doi: 10.1084/jem.20181551.
Perurena N., Zandueta C., Martínez-Canarias S., Moreno H., Vicent S., Almeida A.S., Guruceaga E., Gomis R.R., Santisteban M., Egeblad M., Hermida J., and Lecanda F. (2017) EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth. J Hematol Oncol;10(1):23. doi: 10.1186/s13045-017-0399-x.
Öhlund D., Handly-Santana A., Biffi G., Elyada E., Almeida A.S., Ponz-Sarvise M., Corbo V., Oni T.E., Hearn S.A., Lee E.J., Chio I.I., Hwang C.I., Tiriac H., Baker L.A., Engle D.D., Feig C., Kultti A., Egeblad M., Fearon D.T., Crawford J.M., Clevers H., Park Y., and Tuveson D.A. (2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med, 214:579-596.
Roe J.S., Hwang C.I., Somerville T.D.D., Milazzo J.P., Lee E.J., Da Silva B., Maiorino L., Tiriac H., Young C.M., Miyabayashi K., Filippini D., Creighton B., Burkhart R.A., Buscaglia J.M., Kim E.J., Grem J.L., Lazenby A.J., Grunkemeyer J.A., Hollingsworth M.A., Grandgenett P.M., Egeblad M., Park Y., Tuveson D.A., and Vakoc C.R. (2017) Enhancer reprogramming promotes pancreatic cancer metastasis. Cell, 170, 875-888.
Albrengues, J., Wysocki, R.W., Maiorino, L., Egeblad M. (2017) Preview: Re-cyclin’ cell-cycle components to make NETs. Dev Cell, 43, 379-80.
Arun, G., Diermeier, S., Akerman, M., Chang, K.-C., Wilkinson, J. E., Hearn, S., Kim, Y., MacLeod, A.R., Krainer, A., Norton, L., Brogi, E., Egeblad, M. and Spector, D. L. (2016) Differentiation of mammary tumors and reduction in metastasis upon Malat1 LncRNA loss. Genes Dev, 30, 34-51.
Park, J., Wysocki, R.W., Amoozgar, Z., Maiorino, L., Fein, M.R., Jorns, J., , Schott, A.F., Kinugasa-Katayama, Y., Lee, Y., Won, N.H., Nakasone, E.S., Hearn, S.A., Küttner,V., Qiu, J., Almeida, A.S., Perurena, N., Kessenbrock, K., Goldberg M.S., and Egeblad. M. (2016) Cancer cells trigger neutrophils to induce metastasis-supporting extracellular DNA traps. Sci Transl Med 8, 361ra138
Park, J.-H., Rasch, M.R., Qiu J., Lund I.K., Egeblad, M. (2015) Presence of insulin-like growth factor binding proteins correlates with tumor-promoting effects of matrix metalloproteinase 9 in breast cancer. Neoplasia, 17, 421-33.
Ewald, A.J. and Egeblad M. (2014) Cancer: Sugar-coating cell signalling. Nature, 51:298-9.
Nakasone, E. S, Askautrud, H. A., and Egeblad, M. (2013) Live imaging of drug responses in the tumor microenvironment in mouse models of breast cancer. J Vis Exp, 73, doi: 10.3791/50088.
Rajaram M., Li J., Egeblad M., Powers R.S. (2013) System-wide analysis reveals a complex network of tumor-fibroblast interactions involved in tumorigenecity. PLoS Genet, 9(9):e1003789.
Fein, M. R., and Egeblad, M. (2013) Caught in the Act: Revealing the Metastatic Process by Live Imaging. Dis Model Mech, 6(3):580-93. doi: 10.1242/dmm.009282.
Engelhardt, J.J., Boldajipour, B., Beemiller, P., Pandurangi, P., Sorenson, C., Werb, Z., Egeblad, M., and Krummel, M.F. (2012). Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell, 21, 402-417.
Nakasone, E.S., Askautrud, H.A., Kees , T., Parks, J.-H., Plaks, V., Ewald, A.J., Fein, M., Rasch, M.G., Tan, Y.X., Qiu, J., Park, J., Sinha, P., Bissell, M., Frengen, E., Werb, Z., and Egeblad, M. (2012) Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell, 21, 488-503. Selected for the cover. See also Research Highlights, Nature 2012, 485, 282.
Kees, T. and Egeblad, M. (2011). Innate immune cells in breast cancer – from villains to heroes? J Mammary Gland Biol Neoplasia, 16, 189-203.
Egeblad, M., Nakasone, E.S., and Werb, Z. (2010). The tumor as an organ: complex tissues that interface with the entire organism. Dev Cell, 18, 884-901.
Egeblad M., Rasch, M.G., and Weaver V.M. (2010). Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol, 22, 697-706.
Sounni, N.E., Dehne, K., van Kempen, L.C.L., Egeblad, M., Affara, N.I., Cuevas, I., Wisen J., Junankar, S., Korets, L., Lee, J., Shen, J., Morrison, C.J., Overall, C. M., Krane, S.M., Werb, Z., Boudreau, N., and Coussens, L.M. (2010). Stromal Regulation of Vessel Stability by MMP14 and TGFβ. Dis Model Mech, 3, 317-32.
Levental, K.R., Yu, H., Kass, L., Lakins, J.N., Egeblad, M., Erler J.T., Fong, S.F., Csiszar, K.L., Giaccia, A., Weninger, W., Yamauchi, M., Gasser, D.L., and Weaver, V.M. (2009). Matrix cross-linking forces tumor progression by enhancing integrin signaling. Cell, 139, 891-906.